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Curcumin attenuates malathion-induced lung injury in rats by modulating oxidative stress, inflammation, and fibrosis via Nrf2/HO-1, NF-κB/TNF-α, and COX-2 pathways.

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Title: Curcumin attenuates malathion-induced lung injury in rats by modulating oxidative stress, inflammation, and fibrosis via Nrf2/HO-1, NF-κB/TNF-α, and COX-2 pathways.
Authors: Eldesoqui M; Department of Basic Medical Sciences, College of Medicine, AlMaarefa University, Dariyah, 13713, Saudi Arabia; Research Center, Deanship of Scientific Research and Post-Graduate Studies, AlMaarefa University, Dariyah, 13713; Department of Anatomy and Embryology, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt. Electronic address: mamrah@um.edu.sa., Embaby EM; Department of Physiology, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt. Electronic address: emanmohamed@mans.edu.eg., Fouad RA; Department of Basic Medical Sciences, College of Medicine, AlMaarefa University, Dariyah, 13713, Saudi Arabia; Research Center, Deanship of Scientific Research and Post-Graduate Studies, AlMaarefa University, Dariyah, 13713; Department of Medical Biochemistry, Faculty of Medicine, Zagazig University, Zagazig, Egypt. Electronic address: rfouad@um.edu.sa., Alrajhi YM; College of Medicine, AlMaarefa University, Dariyah, 13713, Saudi Arabia. Electronic address: 221220025@student.um.edu.sa., Mohammed ZA; Forensic medicine and clinical toxicology department, Faculty of Medicine, Zagazig University, Saudi Arabia. Electronic address: ZAMohamed@medicine.zu.edu.eg., Albadawi EA; Department of Basic Medical Sciences, College of Medicine, Taibah University, Saudi Arabia. Electronic address: ebadawi@taibahu.edu.sa., Al-Serwi RH; Department of Basic Dental Sciences, College of Dentistry, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia. Electronic address: rhalserwi@pnu.edu.sa., El-Mansi AA; Biology Department, Faculty of Science, King Khalid University, Abha 61413, Saudi Arabia. Electronic address: aelmansi@kku.edu.sa., Hendawy M; Department of Anatomy and Embryology, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt; Department of Human Anatomy and Embryology, Faculty of Medicine, Al-Baha University, P.O. Box 1988, Al-Baha, Saudi Arabia. Electronic address: hendawy016@mans.edu.eg., Ahmed ME; Department of Anatomy and Embryology, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt. Electronic address: magi86@mans.edu.eg.
Source: Tissue & cell [Tissue Cell] 2026 Feb; Vol. 98, pp. 103144. Date of Electronic Publication: 2025 Sep 16.
Publication Type: Journal Article
Journal Info: Publisher: Churchill Livingstone Country of Publication: Scotland NLM ID: 0214745 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-3072 (Electronic) Linking ISSN: 00408166 NLM ISO Abbreviation: Tissue Cell Subsets: MEDLINE
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  Data: Curcumin attenuates malathion-induced lung injury in rats by modulating oxidative stress, inflammation, and fibrosis via Nrf2/HO-1, NF-κB/TNF-α, and COX-2 pathways.
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  Data: <searchLink fieldCode="AU" term="%22Eldesoqui+M%22">Eldesoqui M</searchLink>; Department of Basic Medical Sciences, College of Medicine, AlMaarefa University, Dariyah, 13713, Saudi Arabia; Research Center, Deanship of Scientific Research and Post-Graduate Studies, AlMaarefa University, Dariyah, 13713; Department of Anatomy and Embryology, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt. Electronic address: mamrah@um.edu.sa.<br /><searchLink fieldCode="AU" term="%22Embaby+EM%22">Embaby EM</searchLink>; Department of Physiology, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt. Electronic address: emanmohamed@mans.edu.eg.<br /><searchLink fieldCode="AU" term="%22Fouad+RA%22">Fouad RA</searchLink>; Department of Basic Medical Sciences, College of Medicine, AlMaarefa University, Dariyah, 13713, Saudi Arabia; Research Center, Deanship of Scientific Research and Post-Graduate Studies, AlMaarefa University, Dariyah, 13713; Department of Medical Biochemistry, Faculty of Medicine, Zagazig University, Zagazig, Egypt. Electronic address: rfouad@um.edu.sa.<br /><searchLink fieldCode="AU" term="%22Alrajhi+YM%22">Alrajhi YM</searchLink>; College of Medicine, AlMaarefa University, Dariyah, 13713, Saudi Arabia. Electronic address: 221220025@student.um.edu.sa.<br /><searchLink fieldCode="AU" term="%22Mohammed+ZA%22">Mohammed ZA</searchLink>; Forensic medicine and clinical toxicology department, Faculty of Medicine, Zagazig University, Saudi Arabia. Electronic address: ZAMohamed@medicine.zu.edu.eg.<br /><searchLink fieldCode="AU" term="%22Albadawi+EA%22">Albadawi EA</searchLink>; Department of Basic Medical Sciences, College of Medicine, Taibah University, Saudi Arabia. Electronic address: ebadawi@taibahu.edu.sa.<br /><searchLink fieldCode="AU" term="%22Al-Serwi+RH%22">Al-Serwi RH</searchLink>; Department of Basic Dental Sciences, College of Dentistry, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia. Electronic address: rhalserwi@pnu.edu.sa.<br /><searchLink fieldCode="AU" term="%22El-Mansi+AA%22">El-Mansi AA</searchLink>; Biology Department, Faculty of Science, King Khalid University, Abha 61413, Saudi Arabia. Electronic address: aelmansi@kku.edu.sa.<br /><searchLink fieldCode="AU" term="%22Hendawy+M%22">Hendawy M</searchLink>; Department of Anatomy and Embryology, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt; Department of Human Anatomy and Embryology, Faculty of Medicine, Al-Baha University, P.O. Box 1988, Al-Baha, Saudi Arabia. Electronic address: hendawy016@mans.edu.eg.<br /><searchLink fieldCode="AU" term="%22Ahmed+ME%22">Ahmed ME</searchLink>; Department of Anatomy and Embryology, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt. Electronic address: magi86@mans.edu.eg.
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              Text: 2026 Feb
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