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Human CD4 T cells are a functional target for lipid nanoparticle-based mRNA vaccines.

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Title: Human CD4 T cells are a functional target for lipid nanoparticle-based mRNA vaccines.
Authors: Kim SC; Department of Physiology & Biophysics, University of California Irvine, Irvine, California, USA.; Institute for Immunology, University of California Irvine, Irvine, California, USA.; Center for Virus Research, University of California Irvine, Irvine, California, USA.; Adeline Yen Mah Vaccine Center, University of California Irvine, Irvine, California, USA., Felgner J; Department of Physiology & Biophysics, University of California Irvine, Irvine, California, USA.; Institute for Immunology, University of California Irvine, Irvine, California, USA.; Center for Virus Research, University of California Irvine, Irvine, California, USA.; Adeline Yen Mah Vaccine Center, University of California Irvine, Irvine, California, USA., Soto MS; Department of Physiology & Biophysics, University of California Irvine, Irvine, California, USA.; Institute for Immunology, University of California Irvine, Irvine, California, USA.; Center for Virus Research, University of California Irvine, Irvine, California, USA.; Adeline Yen Mah Vaccine Center, University of California Irvine, Irvine, California, USA., Hitchcock L; Division of Infectious Diseases, University of California Irvine, Irvine, California, USA., Silzel EK; Department of Physiology & Biophysics, University of California Irvine, Irvine, California, USA.; Institute for Immunology, University of California Irvine, Irvine, California, USA.; Center for Virus Research, University of California Irvine, Irvine, California, USA.; Adeline Yen Mah Vaccine Center, University of California Irvine, Irvine, California, USA., Beares H; Department of Physiology & Biophysics, University of California Irvine, Irvine, California, USA.; Institute for Immunology, University of California Irvine, Irvine, California, USA.; Center for Virus Research, University of California Irvine, Irvine, California, USA.; Adeline Yen Mah Vaccine Center, University of California Irvine, Irvine, California, USA., Hwang MJ; Department of Physiology & Biophysics, University of California Irvine, Irvine, California, USA.; Institute for Immunology, University of California Irvine, Irvine, California, USA.; Center for Virus Research, University of California Irvine, Irvine, California, USA.; Adeline Yen Mah Vaccine Center, University of California Irvine, Irvine, California, USA., Yates TB; Department of Physiology & Biophysics, University of California Irvine, Irvine, California, USA.; Institute for Immunology, University of California Irvine, Irvine, California, USA.; Center for Virus Research, University of California Irvine, Irvine, California, USA.; Adeline Yen Mah Vaccine Center, University of California Irvine, Irvine, California, USA., Cheng S; Department of Physiology & Biophysics, University of California Irvine, Irvine, California, USA.; Institute for Immunology, University of California Irvine, Irvine, California, USA.; Center for Virus Research, University of California Irvine, Irvine, California, USA.; Adeline Yen Mah Vaccine Center, University of California Irvine, Irvine, California, USA., Joloya EM; Department of Physiology & Biophysics, University of California Irvine, Irvine, California, USA.; Institute for Immunology, University of California Irvine, Irvine, California, USA.; Center for Virus Research, University of California Irvine, Irvine, California, USA.; Adeline Yen Mah Vaccine Center, University of California Irvine, Irvine, California, USA., Sureshchandra S; Department of Physiology & Biophysics, University of California Irvine, Irvine, California, USA.; Institute for Immunology, University of California Irvine, Irvine, California, USA.; Center for Virus Research, University of California Irvine, Irvine, California, USA.; Adeline Yen Mah Vaccine Center, University of California Irvine, Irvine, California, USA., Sorn AM; Department of Physiology & Biophysics, University of California Irvine, Irvine, California, USA.; Institute for Immunology, University of California Irvine, Irvine, California, USA.; Center for Virus Research, University of California Irvine, Irvine, California, USA.; Adeline Yen Mah Vaccine Center, University of California Irvine, Irvine, California, USA., Wagoner ZW; Department of Physiology & Biophysics, University of California Irvine, Irvine, California, USA.; Institute for Immunology, University of California Irvine, Irvine, California, USA.; Center for Virus Research, University of California Irvine, Irvine, California, USA.; Adeline Yen Mah Vaccine Center, University of California Irvine, Irvine, California, USA., Tifrea D; Department of Pathology and Laboratory Medicine, University of California Irvine, Orange, California, USA., Kabeer M; Division of Pediatric Surgery, Children's Hospital of Orange County, Orange, California, USA., Trask D; Department of Otolaryngology-Head and Neck Surgery, University of California Irvine, Orange, California, USA., Othy S; Department of Physiology & Biophysics, University of California Irvine, Irvine, California, USA.; Institute for Immunology, University of California Irvine, Irvine, California, USA.; Adeline Yen Mah Vaccine Center, University of California Irvine, Irvine, California, USA., Felgner P; Department of Physiology & Biophysics, University of California Irvine, Irvine, California, USA.; Institute for Immunology, University of California Irvine, Irvine, California, USA.; Center for Virus Research, University of California Irvine, Irvine, California, USA.; Adeline Yen Mah Vaccine Center, University of California Irvine, Irvine, California, USA., Wagar LE; Department of Physiology & Biophysics, University of California Irvine, Irvine, California, USA.; Institute for Immunology, University of California Irvine, Irvine, California, USA.; Center for Virus Research, University of California Irvine, Irvine, California, USA.; Adeline Yen Mah Vaccine Center, University of California Irvine, Irvine, California, USA.
Source: MBio [mBio] 2025 Nov 12; Vol. 16 (11), pp. e0225425. Date of Electronic Publication: 2025 Sep 22.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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PreciseRelevancyScore: 0
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  Data: Human CD4 T cells are a functional target for lipid nanoparticle-based mRNA vaccines.
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  Data: <searchLink fieldCode="AU" term="%22Kim+SC%22">Kim SC</searchLink>; Department of Physiology & Biophysics, University of California Irvine, Irvine, California, USA.; Institute for Immunology, University of California Irvine, Irvine, California, USA.; Center for Virus Research, University of California Irvine, Irvine, California, USA.; Adeline Yen Mah Vaccine Center, University of California Irvine, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Felgner+J%22">Felgner J</searchLink>; Department of Physiology & Biophysics, University of California Irvine, Irvine, California, USA.; Institute for Immunology, University of California Irvine, Irvine, California, USA.; Center for Virus Research, University of California Irvine, Irvine, California, USA.; Adeline Yen Mah Vaccine Center, University of California Irvine, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Soto+MS%22">Soto MS</searchLink>; Department of Physiology & Biophysics, University of California Irvine, Irvine, California, USA.; Institute for Immunology, University of California Irvine, Irvine, California, USA.; Center for Virus Research, University of California Irvine, Irvine, California, USA.; Adeline Yen Mah Vaccine Center, University of California Irvine, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Hitchcock+L%22">Hitchcock L</searchLink>; Division of Infectious Diseases, University of California Irvine, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Silzel+EK%22">Silzel EK</searchLink>; Department of Physiology & Biophysics, University of California Irvine, Irvine, California, USA.; Institute for Immunology, University of California Irvine, Irvine, California, USA.; Center for Virus Research, University of California Irvine, Irvine, California, USA.; Adeline Yen Mah Vaccine Center, University of California Irvine, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Beares+H%22">Beares H</searchLink>; Department of Physiology & Biophysics, University of California Irvine, Irvine, California, USA.; Institute for Immunology, University of California Irvine, Irvine, California, USA.; Center for Virus Research, University of California Irvine, Irvine, California, USA.; Adeline Yen Mah Vaccine Center, University of California Irvine, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Hwang+MJ%22">Hwang MJ</searchLink>; Department of Physiology & Biophysics, University of California Irvine, Irvine, California, USA.; Institute for Immunology, University of California Irvine, Irvine, California, USA.; Center for Virus Research, University of California Irvine, Irvine, California, USA.; Adeline Yen Mah Vaccine Center, University of California Irvine, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Yates+TB%22">Yates TB</searchLink>; Department of Physiology & Biophysics, University of California Irvine, Irvine, California, USA.; Institute for Immunology, University of California Irvine, Irvine, California, USA.; Center for Virus Research, University of California Irvine, Irvine, California, USA.; Adeline Yen Mah Vaccine Center, University of California Irvine, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Cheng+S%22">Cheng S</searchLink>; Department of Physiology & Biophysics, University of California Irvine, Irvine, California, USA.; Institute for Immunology, University of California Irvine, Irvine, California, USA.; Center for Virus Research, University of California Irvine, Irvine, California, USA.; Adeline Yen Mah Vaccine Center, University of California Irvine, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Joloya+EM%22">Joloya EM</searchLink>; Department of Physiology & Biophysics, University of California Irvine, Irvine, California, USA.; Institute for Immunology, University of California Irvine, Irvine, California, USA.; Center for Virus Research, University of California Irvine, Irvine, California, USA.; Adeline Yen Mah Vaccine Center, University of California Irvine, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Sureshchandra+S%22">Sureshchandra S</searchLink>; Department of Physiology & Biophysics, University of California Irvine, Irvine, California, USA.; Institute for Immunology, University of California Irvine, Irvine, California, USA.; Center for Virus Research, University of California Irvine, Irvine, California, USA.; Adeline Yen Mah Vaccine Center, University of California Irvine, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Sorn+AM%22">Sorn AM</searchLink>; Department of Physiology & Biophysics, University of California Irvine, Irvine, California, USA.; Institute for Immunology, University of California Irvine, Irvine, California, USA.; Center for Virus Research, University of California Irvine, Irvine, California, USA.; Adeline Yen Mah Vaccine Center, University of California Irvine, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Wagoner+ZW%22">Wagoner ZW</searchLink>; Department of Physiology & Biophysics, University of California Irvine, Irvine, California, USA.; Institute for Immunology, University of California Irvine, Irvine, California, USA.; Center for Virus Research, University of California Irvine, Irvine, California, USA.; Adeline Yen Mah Vaccine Center, University of California Irvine, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Tifrea+D%22">Tifrea D</searchLink>; Department of Pathology and Laboratory Medicine, University of California Irvine, Orange, California, USA.<br /><searchLink fieldCode="AU" term="%22Kabeer+M%22">Kabeer M</searchLink>; Division of Pediatric Surgery, Children's Hospital of Orange County, Orange, California, USA.<br /><searchLink fieldCode="AU" term="%22Trask+D%22">Trask D</searchLink>; Department of Otolaryngology-Head and Neck Surgery, University of California Irvine, Orange, California, USA.<br /><searchLink fieldCode="AU" term="%22Othy+S%22">Othy S</searchLink>; Department of Physiology & Biophysics, University of California Irvine, Irvine, California, USA.; Institute for Immunology, University of California Irvine, Irvine, California, USA.; Adeline Yen Mah Vaccine Center, University of California Irvine, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Felgner+P%22">Felgner P</searchLink>; Department of Physiology & Biophysics, University of California Irvine, Irvine, California, USA.; Institute for Immunology, University of California Irvine, Irvine, California, USA.; Center for Virus Research, University of California Irvine, Irvine, California, USA.; Adeline Yen Mah Vaccine Center, University of California Irvine, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Wagar+LE%22">Wagar LE</searchLink>; Department of Physiology & Biophysics, University of California Irvine, Irvine, California, USA.; Institute for Immunology, University of California Irvine, Irvine, California, USA.; Center for Virus Research, University of California Irvine, Irvine, California, USA.; Adeline Yen Mah Vaccine Center, University of California Irvine, Irvine, California, USA.
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  Data: <searchLink fieldCode="JN" term="%22101519231%22">MBio</searchLink> [mBio] 2025 Nov 12; Vol. 16 (11), pp. e0225425. <i>Date of Electronic Publication: </i>2025 Sep 22.
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