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Target antigen and plasma cell phenotype are critical factors for sensitivity to response-adapted daratumumab therapy.

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Title: Target antigen and plasma cell phenotype are critical factors for sensitivity to response-adapted daratumumab therapy.
Authors: Meads MB; Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL., Zhao X; Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL., Noyes D; Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL., Sudalagunta PR; Department of Cancer Physiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL., Achille A; Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL., Zhang C; Molecular Genomics Core Facility, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL., Canevarolo RR; Department of Cancer Physiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL., Silva M; Department of Cancer Physiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL., Magaletti D; Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL., DeAvila D; Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL., Toska S; Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL., Oates A; Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL., Lastorino D; Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL., Idiaquez DW; Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL., Song J; Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL., Sansil SS; Cancer Pharmacokinetics and Pharmacodynamics Core, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL., Yoder SJ; Molecular Genomics Core Facility, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL., Grajales-Cruz AF; Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL., Blue B; Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL., Freeman CL; Department of Blood and Marrow Transplant and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL., Kim J; Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL., Alsina M; Department of Blood and Marrow Transplant and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL., Brayer J; Departments of Malignant Hematology and Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL., Silva AS; Department of Cancer Physiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL., Song X; Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL., Shain KH; Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL., Baz R; Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.
Source: Blood [Blood] 2026 Jan 29; Vol. 147 (5), pp. 497-512.
Publication Type: Clinical Trial, Phase II; Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Meads+MB%22">Meads MB</searchLink>; Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.<br /><searchLink fieldCode="AU" term="%22Zhao+X%22">Zhao X</searchLink>; Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.<br /><searchLink fieldCode="AU" term="%22Noyes+D%22">Noyes D</searchLink>; Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.<br /><searchLink fieldCode="AU" term="%22Sudalagunta+PR%22">Sudalagunta PR</searchLink>; Department of Cancer Physiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.<br /><searchLink fieldCode="AU" term="%22Achille+A%22">Achille A</searchLink>; Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.<br /><searchLink fieldCode="AU" term="%22Zhang+C%22">Zhang C</searchLink>; Molecular Genomics Core Facility, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.<br /><searchLink fieldCode="AU" term="%22Canevarolo+RR%22">Canevarolo RR</searchLink>; Department of Cancer Physiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.<br /><searchLink fieldCode="AU" term="%22Silva+M%22">Silva M</searchLink>; Department of Cancer Physiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.<br /><searchLink fieldCode="AU" term="%22Magaletti+D%22">Magaletti D</searchLink>; Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.<br /><searchLink fieldCode="AU" term="%22DeAvila+D%22">DeAvila D</searchLink>; Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.<br /><searchLink fieldCode="AU" term="%22Toska+S%22">Toska S</searchLink>; Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.<br /><searchLink fieldCode="AU" term="%22Oates+A%22">Oates A</searchLink>; Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.<br /><searchLink fieldCode="AU" term="%22Lastorino+D%22">Lastorino D</searchLink>; Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.<br /><searchLink fieldCode="AU" term="%22Idiaquez+DW%22">Idiaquez DW</searchLink>; Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.<br /><searchLink fieldCode="AU" term="%22Song+J%22">Song J</searchLink>; Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.<br /><searchLink fieldCode="AU" term="%22Sansil+SS%22">Sansil SS</searchLink>; Cancer Pharmacokinetics and Pharmacodynamics Core, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.<br /><searchLink fieldCode="AU" term="%22Yoder+SJ%22">Yoder SJ</searchLink>; Molecular Genomics Core Facility, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.<br /><searchLink fieldCode="AU" term="%22Grajales-Cruz+AF%22">Grajales-Cruz AF</searchLink>; Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.<br /><searchLink fieldCode="AU" term="%22Blue+B%22">Blue B</searchLink>; Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.<br /><searchLink fieldCode="AU" term="%22Freeman+CL%22">Freeman CL</searchLink>; Department of Blood and Marrow Transplant and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.<br /><searchLink fieldCode="AU" term="%22Kim+J%22">Kim J</searchLink>; Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.<br /><searchLink fieldCode="AU" term="%22Alsina+M%22">Alsina M</searchLink>; Department of Blood and Marrow Transplant and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.<br /><searchLink fieldCode="AU" term="%22Brayer+J%22">Brayer J</searchLink>; Departments of Malignant Hematology and Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.<br /><searchLink fieldCode="AU" term="%22Silva+AS%22">Silva AS</searchLink>; Department of Cancer Physiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.<br /><searchLink fieldCode="AU" term="%22Song+X%22">Song X</searchLink>; Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.<br /><searchLink fieldCode="AU" term="%22Shain+KH%22">Shain KH</searchLink>; Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.<br /><searchLink fieldCode="AU" term="%22Baz+R%22">Baz R</searchLink>; Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7603509 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1528-0020 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200064971%22">00064971 </searchLink><i>NLM ISO Abbreviation: </i>Blood <i>Subsets: </i>MEDLINE
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