View in EDS

CRISPR Screens Identify PIK3C2A as a Novel Mediator of EGFR Inhibitor Resistance in Head and Neck Squamous Cell Carcinoma.

Saved in:
Bibliographic Details
Title: CRISPR Screens Identify PIK3C2A as a Novel Mediator of EGFR Inhibitor Resistance in Head and Neck Squamous Cell Carcinoma.
Authors: Wang J; Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, USA.; Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA., Ludwig ML; Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA.; Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, Michigan, USA., Kulkarni A; Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA., Birkeland AC; Department of Otolaryngology-Head and Neck Surgery, University of California, Davis, California, USA., Michmerhuizen NL; Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, USA.; Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA., Gensterblum-Miller E; Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA.; Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, Michigan, USA., Zhai J; Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA., Jiang H; Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan, USA., Swiecicki P; Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan, USA.; Department of Hematology Oncology, University of Michigan, Ann Arbor, Michigan, USA., Buchakjian M; Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA., Heft Neal M; Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA., Chinn SB; Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA., Spector ME; University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Brenner JC; Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, USA.; Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA.; Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, Michigan, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan, USA.
Source: Head & neck [Head Neck] 2026 Feb; Vol. 48 (2), pp. 486-495. Date of Electronic Publication: 2025 Sep 23.
Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural
Journal Info: Publisher: John Wiley And Sons Country of Publication: United States NLM ID: 8902541 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0347 (Electronic) Linking ISSN: 10433074 NLM ISO Abbreviation: Head Neck Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 40985049
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: CRISPR Screens Identify PIK3C2A as a Novel Mediator of EGFR Inhibitor Resistance in Head and Neck Squamous Cell Carcinoma.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, USA.; Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Ludwig+ML%22">Ludwig ML</searchLink>; Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA.; Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Kulkarni+A%22">Kulkarni A</searchLink>; Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Birkeland+AC%22">Birkeland AC</searchLink>; Department of Otolaryngology-Head and Neck Surgery, University of California, Davis, California, USA.<br /><searchLink fieldCode="AU" term="%22Michmerhuizen+NL%22">Michmerhuizen NL</searchLink>; Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, USA.; Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Gensterblum-Miller+E%22">Gensterblum-Miller E</searchLink>; Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA.; Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Zhai+J%22">Zhai J</searchLink>; Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Jiang+H%22">Jiang H</searchLink>; Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Swiecicki+P%22">Swiecicki P</searchLink>; Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan, USA.; Department of Hematology Oncology, University of Michigan, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Buchakjian+M%22">Buchakjian M</searchLink>; Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Heft+Neal+M%22">Heft Neal M</searchLink>; Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Chinn+SB%22">Chinn SB</searchLink>; Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Spector+ME%22">Spector ME</searchLink>; University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Brenner+JC%22">Brenner JC</searchLink>; Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, USA.; Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA.; Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, Michigan, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan, USA.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%228902541%22">Head & neck</searchLink> [Head Neck] 2026 Feb; Vol. 48 (2), pp. 486-495. <i>Date of Electronic Publication: </i>2025 Sep 23.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22John+Wiley+And+Sons%22">John Wiley And Sons </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>8902541 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1097-0347 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210433074%22">10433074 </searchLink><i>NLM ISO Abbreviation: </i>Head Neck <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40985049
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1002/hed.70048
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 486
    Titles:
      – TitleFull: CRISPR Screens Identify PIK3C2A as a Novel Mediator of EGFR Inhibitor Resistance in Head and Neck Squamous Cell Carcinoma.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Wang J
      – PersonEntity:
          Name:
            NameFull: Ludwig ML
      – PersonEntity:
          Name:
            NameFull: Kulkarni A
      – PersonEntity:
          Name:
            NameFull: Birkeland AC
      – PersonEntity:
          Name:
            NameFull: Michmerhuizen NL
      – PersonEntity:
          Name:
            NameFull: Gensterblum-Miller E
      – PersonEntity:
          Name:
            NameFull: Zhai J
      – PersonEntity:
          Name:
            NameFull: Jiang H
      – PersonEntity:
          Name:
            NameFull: Swiecicki P
      – PersonEntity:
          Name:
            NameFull: Buchakjian M
      – PersonEntity:
          Name:
            NameFull: Heft Neal M
      – PersonEntity:
          Name:
            NameFull: Chinn SB
      – PersonEntity:
          Name:
            NameFull: Spector ME
      – PersonEntity:
          Name:
            NameFull: Brenner JC
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 02
              Text: 2026 Feb
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1097-0347
          Numbering:
            – Type: volume
              Value: 48
            – Type: issue
              Value: 2
          Titles:
            – TitleFull: Head & neck
              Type: main
ResultId 1