Resilience to Endoplasmic Reticulum Stress Mitigates Membrane Hyperexcitability Underlying Late Disease Onset in a Murine Model of SCA6.

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Title: Resilience to Endoplasmic Reticulum Stress Mitigates Membrane Hyperexcitability Underlying Late Disease Onset in a Murine Model of SCA6.
Authors: Huang H; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX.; Medical Scientist Training Program, The Ohio State University College of Medicine, Columbus, OH., Charron TL; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX.; University of Texas Southwestern Medical School, Dallas, TX., Fu M; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX., Dunn M; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX., Jones DM; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX., Kumar P; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX., Ishishita S; Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX., Pool AH; Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX.; Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center, Dallas, TX.; Peter O'Donnell Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX., Kulkarni A; Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX.; Peter O'Donnell Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX., Konopka G; Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX.; Peter O'Donnell Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX.; Department of Neurobiology, UCLA David Geffen School of Medicine, Los Angeles, CA., Shakkottai VG; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX.; Peter O'Donnell Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX.
Source: Annals of neurology [Ann Neurol] 2026 Feb; Vol. 99 (2), pp. 502-522. Date of Electronic Publication: 2025 Sep 24.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7707449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1531-8249 (Electronic) Linking ISSN: 03645134 NLM ISO Abbreviation: Ann Neurol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1531-8249
DOI:10.1002/ana.78042