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Resilience to Endoplasmic Reticulum Stress Mitigates Membrane Hyperexcitability Underlying Late Disease Onset in a Murine Model of SCA6.

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Title: Resilience to Endoplasmic Reticulum Stress Mitigates Membrane Hyperexcitability Underlying Late Disease Onset in a Murine Model of SCA6.
Authors: Huang H; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX.; Medical Scientist Training Program, The Ohio State University College of Medicine, Columbus, OH., Charron TL; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX.; University of Texas Southwestern Medical School, Dallas, TX., Fu M; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX., Dunn M; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX., Jones DM; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX., Kumar P; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX., Ishishita S; Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX., Pool AH; Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX.; Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center, Dallas, TX.; Peter O'Donnell Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX., Kulkarni A; Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX.; Peter O'Donnell Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX., Konopka G; Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX.; Peter O'Donnell Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX.; Department of Neurobiology, UCLA David Geffen School of Medicine, Los Angeles, CA., Shakkottai VG; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX.; Peter O'Donnell Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX.
Source: Annals of neurology [Ann Neurol] 2026 Feb; Vol. 99 (2), pp. 502-522. Date of Electronic Publication: 2025 Sep 24.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7707449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1531-8249 (Electronic) Linking ISSN: 03645134 NLM ISO Abbreviation: Ann Neurol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Huang+H%22">Huang H</searchLink>; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX.; Medical Scientist Training Program, The Ohio State University College of Medicine, Columbus, OH.<br /><searchLink fieldCode="AU" term="%22Charron+TL%22">Charron TL</searchLink>; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX.; University of Texas Southwestern Medical School, Dallas, TX.<br /><searchLink fieldCode="AU" term="%22Fu+M%22">Fu M</searchLink>; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX.<br /><searchLink fieldCode="AU" term="%22Dunn+M%22">Dunn M</searchLink>; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX.<br /><searchLink fieldCode="AU" term="%22Jones+DM%22">Jones DM</searchLink>; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX.<br /><searchLink fieldCode="AU" term="%22Kumar+P%22">Kumar P</searchLink>; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX.<br /><searchLink fieldCode="AU" term="%22Ishishita+S%22">Ishishita S</searchLink>; Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX.<br /><searchLink fieldCode="AU" term="%22Pool+AH%22">Pool AH</searchLink>; Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX.; Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center, Dallas, TX.; Peter O'Donnell Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX.<br /><searchLink fieldCode="AU" term="%22Kulkarni+A%22">Kulkarni A</searchLink>; Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX.; Peter O'Donnell Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX.<br /><searchLink fieldCode="AU" term="%22Konopka+G%22">Konopka G</searchLink>; Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX.; Peter O'Donnell Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX.; Department of Neurobiology, UCLA David Geffen School of Medicine, Los Angeles, CA.<br /><searchLink fieldCode="AU" term="%22Shakkottai+VG%22">Shakkottai VG</searchLink>; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX.; Peter O'Donnell Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX.
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  Data: <searchLink fieldCode="JN" term="%227707449%22">Annals of neurology</searchLink> [Ann Neurol] 2026 Feb; Vol. 99 (2), pp. 502-522. <i>Date of Electronic Publication: </i>2025 Sep 24.
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              Text: 2026 Feb
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