Development and clinical validation of a novel protein biomarkers-based algorithm for risk prediction and diagnosis of advanced liver fibrosis: a multi-centre study.

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Title: Development and clinical validation of a novel protein biomarkers-based algorithm for risk prediction and diagnosis of advanced liver fibrosis: a multi-centre study.
Authors: Cheung CY; State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong, China; Department of Medicine, School of Clinical Medicine, University of Hong Kong, Hong Kong, China; Guangdong-Hong Kong Joint Institute for Metabolic Medicine, University of Hong Kong, Hong Kong, China., Wan P; State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong, China; Department of Medicine, School of Clinical Medicine, University of Hong Kong, Hong Kong, China; Guangdong-Hong Kong Joint Institute for Metabolic Medicine, University of Hong Kong, Hong Kong, China., Wan H; Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Foshan City, Guangdong, China., Xu C; State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong, China; Department of Medicine, School of Clinical Medicine, University of Hong Kong, Hong Kong, China; Guangdong-Hong Kong Joint Institute for Metabolic Medicine, University of Hong Kong, Hong Kong, China., Jia X; State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong, China; Department of Medicine, School of Clinical Medicine, University of Hong Kong, Hong Kong, China; Guangdong-Hong Kong Joint Institute for Metabolic Medicine, University of Hong Kong, Hong Kong, China., Fong CH; State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong, China., Lui DT; State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong, China; Department of Medicine, School of Clinical Medicine, University of Hong Kong, Hong Kong, China; Guangdong-Hong Kong Joint Institute for Metabolic Medicine, University of Hong Kong, Hong Kong, China., Song E; State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong, China; Department of Medicine, School of Clinical Medicine, University of Hong Kong, Hong Kong, China; Guangdong-Hong Kong Joint Institute for Metabolic Medicine, University of Hong Kong, Hong Kong, China., Chen X; Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Foshan City, Guangdong, China., Chow WS; State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong, China., Woo YC; State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong, China., Tan KC; State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong, China., Seto WK; State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong, China., Wang C; Department of Metabolic and Bariatric Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, China., Shen J; Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Foshan City, Guangdong, China. Electronic address: sjiesy@smu.edu.cn., Lam KS; State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong, China; Department of Medicine, School of Clinical Medicine, University of Hong Kong, Hong Kong, China; Guangdong-Hong Kong Joint Institute for Metabolic Medicine, University of Hong Kong, Hong Kong, China. Electronic address: ksllam@hku.hk., Lee CH; State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong, China; Department of Medicine, School of Clinical Medicine, University of Hong Kong, Hong Kong, China; Guangdong-Hong Kong Joint Institute for Metabolic Medicine, University of Hong Kong, Hong Kong, China. Electronic address: pchlee@hku.hk., Xu A; State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong, China; Department of Medicine, School of Clinical Medicine, University of Hong Kong, Hong Kong, China; Guangdong-Hong Kong Joint Institute for Metabolic Medicine, University of Hong Kong, Hong Kong, China. Electronic address: amxu@hku.hk.
Source: Journal of advanced research [J Adv Res] 2026 Jun; Vol. 84, pp. 871-881. Date of Electronic Publication: 2025 Sep 22.
Publication Type: Journal Article; Multicenter Study; Validation Study; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cairo University, production and hosting by Elsevier B. V Country of Publication: Egypt NLM ID: 101546952 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2090-1224 (Electronic) Linking ISSN: 20901224 NLM ISO Abbreviation: J Adv Res Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2090-1224
DOI:10.1016/j.jare.2025.09.033