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Changes in use and utilisation patterns of drugs with reported shortages between 2010 and 2024 in Europe and North America: a network cohort study.

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Title: Changes in use and utilisation patterns of drugs with reported shortages between 2010 and 2024 in Europe and North America: a network cohort study.
Authors: Pineda-Moncusí M; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Centre for Statistics in Medicine, University of Oxford, Oxford, UK., Rekkas A; Institute of Applied Biosciences, Centre for Research and Technology, Hellas, Greece., Martínez Pérez Á; Joint Research Unit on ICT Applied to the Reengineering of Socio-Healthcare Processes, The Health Research Institute Hospital La Fe, Valencia, Spain., Leis A; Research Programme on Biomedical Informatics, Hospital del Mar Research Institute, Barcelona, Spain., Lopez Gomez C; Big Data, AI, Biostatistics, and Bioinformatics Platform, The Health Research Institute Hospital La Fe, Valencia, Spain., Fey E; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Bruninx E; Medical Affairs Department, Pfizer, Brussels, Belgium., Maljković F; Heliant, Belgrade, Serbia., Sánchez-Sáez F; Health Services Research and Pharmacoepidemiology Unit, FISABIO, Valencia, Spain; Department of Applied Statistics and Operational Research, and Quality, Universitat Politècnica de València, Valencia, Spain., Rodeiro-Boliart J; Impacte i Prevenció dels Trastorns Mentals, Institut de Recerca Sant Joan de Déu, Sant Boi de Llobregat, Spain., Zsuzsa Kiss L; Institute for Clinical Data Management, Semmelweis University, Budapest, Hungary., Franz M; Center of Health Data Science, Berlin Institute of Health at Charité, Universitätsmedizin Berlin, Berlin, Germany., Mayer MA; Research Programme on Biomedical Informatics, Hospital del Mar Research Institute, Barcelona, Spain; Department of Control and Management, Hospital del Mar, Barcelona, Spain., Eleangovan N; Observational and Pragmatic Research Institute, Singapore., Pulido PP; Health Data Research Platform, Health Research Institute of the Balearic Islands, Palma, Spain., Natsiavas P; Institute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki, Greece., Şen S; Division of Clinical Pharmacology, Department of Medical Pharmacology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiye., Cooper S; Optimum Patient Care, Oakington, UK., Reisberg S; Institute of Computer Science, University of Tartu, Tartu, Estonia; STACC, Tartu, Estonia., Manlik K; Pharmaceuticals and Integrated Evidence Generation, Bayer, Berlin, Germany., Price DB; Observational and Pragmatic Research Institute, Singapore; Centre of Academic Primary Care, Division of Applied Health Sciences, University of Aberdeen, Aberdeen, UK., Moscetti L; Division of Oncology, Azienda Ospedaliera Universitaria di Modena, Modena, Italy., Merkelbach M; VieCuri Medical Center, Venlo, Netherlands., Tadrous M; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada., Rappoport N; Software and Information Systems Engineering, Ben-Gurion University of the Negev, Beersheba, Israel., Claire R; National Institute for Health and Care Excellence, London, UK., Garcia-Torrens S; Hospital de Denia, Alicante, Spain., Prieto-Alhambra D; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Centre for Statistics in Medicine, University of Oxford, Oxford, UK; Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, Netherlands. Electronic address: daniel.prietoalhambra@ndorms.ox.ac.uk., Rijnbeek PR; Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, Netherlands., Burkard T; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Centre for Statistics in Medicine, University of Oxford, Oxford, UK.
Corporate Authors: Drug Shortages EHDEN Study Group
Source: The Lancet. Public health [Lancet Public Health] 2025 Oct; Vol. 10 (10), pp. e835-e847.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier, Ltd Country of Publication: England NLM ID: 101699003 Publication Model: Print Cited Medium: Internet ISSN: 2468-2667 (Electronic) NLM ISO Abbreviation: Lancet Public Health Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Pineda-Moncusí+M%22">Pineda-Moncusí M</searchLink>; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Centre for Statistics in Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Rekkas+A%22">Rekkas A</searchLink>; Institute of Applied Biosciences, Centre for Research and Technology, Hellas, Greece.<br /><searchLink fieldCode="AU" term="%22Martínez+Pérez+Á%22">Martínez Pérez Á</searchLink>; Joint Research Unit on ICT Applied to the Reengineering of Socio-Healthcare Processes, The Health Research Institute Hospital La Fe, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Leis+A%22">Leis A</searchLink>; Research Programme on Biomedical Informatics, Hospital del Mar Research Institute, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Lopez+Gomez+C%22">Lopez Gomez C</searchLink>; Big Data, AI, Biostatistics, and Bioinformatics Platform, The Health Research Institute Hospital La Fe, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Fey+E%22">Fey E</searchLink>; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Bruninx+E%22">Bruninx E</searchLink>; Medical Affairs Department, Pfizer, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Maljković+F%22">Maljković F</searchLink>; Heliant, Belgrade, Serbia.<br /><searchLink fieldCode="AU" term="%22Sánchez-Sáez+F%22">Sánchez-Sáez F</searchLink>; Health Services Research and Pharmacoepidemiology Unit, FISABIO, Valencia, Spain; Department of Applied Statistics and Operational Research, and Quality, Universitat Politècnica de València, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Rodeiro-Boliart+J%22">Rodeiro-Boliart J</searchLink>; Impacte i Prevenció dels Trastorns Mentals, Institut de Recerca Sant Joan de Déu, Sant Boi de Llobregat, Spain.<br /><searchLink fieldCode="AU" term="%22Zsuzsa+Kiss+L%22">Zsuzsa Kiss L</searchLink>; Institute for Clinical Data Management, Semmelweis University, Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Franz+M%22">Franz M</searchLink>; Center of Health Data Science, Berlin Institute of Health at Charité, Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Mayer+MA%22">Mayer MA</searchLink>; Research Programme on Biomedical Informatics, Hospital del Mar Research Institute, Barcelona, Spain; Department of Control and Management, Hospital del Mar, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Eleangovan+N%22">Eleangovan N</searchLink>; Observational and Pragmatic Research Institute, Singapore.<br /><searchLink fieldCode="AU" term="%22Pulido+PP%22">Pulido PP</searchLink>; Health Data Research Platform, Health Research Institute of the Balearic Islands, Palma, Spain.<br /><searchLink fieldCode="AU" term="%22Natsiavas+P%22">Natsiavas P</searchLink>; Institute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki, Greece.<br /><searchLink fieldCode="AU" term="%22Şen+S%22">Şen S</searchLink>; Division of Clinical Pharmacology, Department of Medical Pharmacology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiye.<br /><searchLink fieldCode="AU" term="%22Cooper+S%22">Cooper S</searchLink>; Optimum Patient Care, Oakington, UK.<br /><searchLink fieldCode="AU" term="%22Reisberg+S%22">Reisberg S</searchLink>; Institute of Computer Science, University of Tartu, Tartu, Estonia; STACC, Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Manlik+K%22">Manlik K</searchLink>; Pharmaceuticals and Integrated Evidence Generation, Bayer, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Price+DB%22">Price DB</searchLink>; Observational and Pragmatic Research Institute, Singapore; Centre of Academic Primary Care, Division of Applied Health Sciences, University of Aberdeen, Aberdeen, UK.<br /><searchLink fieldCode="AU" term="%22Moscetti+L%22">Moscetti L</searchLink>; Division of Oncology, Azienda Ospedaliera Universitaria di Modena, Modena, Italy.<br /><searchLink fieldCode="AU" term="%22Merkelbach+M%22">Merkelbach M</searchLink>; VieCuri Medical Center, Venlo, Netherlands.<br /><searchLink fieldCode="AU" term="%22Tadrous+M%22">Tadrous M</searchLink>; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Rappoport+N%22">Rappoport N</searchLink>; Software and Information Systems Engineering, Ben-Gurion University of the Negev, Beersheba, Israel.<br /><searchLink fieldCode="AU" term="%22Claire+R%22">Claire R</searchLink>; National Institute for Health and Care Excellence, London, UK.<br /><searchLink fieldCode="AU" term="%22Garcia-Torrens+S%22">Garcia-Torrens S</searchLink>; Hospital de Denia, Alicante, Spain.<br /><searchLink fieldCode="AU" term="%22Prieto-Alhambra+D%22">Prieto-Alhambra D</searchLink>; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Centre for Statistics in Medicine, University of Oxford, Oxford, UK; Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, Netherlands. Electronic address: daniel.prietoalhambra@ndorms.ox.ac.uk.<br /><searchLink fieldCode="AU" term="%22Rijnbeek+PR%22">Rijnbeek PR</searchLink>; Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Burkard+T%22">Burkard T</searchLink>; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Centre for Statistics in Medicine, University of Oxford, Oxford, UK.
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