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Discovery of Potent and Selective Reversible Ubiquitin-Like Modifier Activating Enzyme 5 Inhibitors Targeting the UFMylation Pathway.

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Title: Discovery of Potent and Selective Reversible Ubiquitin-Like Modifier Activating Enzyme 5 Inhibitors Targeting the UFMylation Pathway.
Authors: Mignone JJ; Bristol Myers Squibb Research & Early Development, Princeton, New Jersey 08543, United States., Jurica EA; Bristol Myers Squibb Research & Early Development, Princeton, New Jersey 08543, United States., Rajasekaran D; Bristol Myers Squibb Research & Early Development, Princeton, New Jersey 08543, United States., Robustelli J; Bristol Myers Squibb Research & Early Development, Princeton, New Jersey 08543, United States., McCarthy C; Bristol Myers Squibb Research & Early Development, 100 Binney Street, Cambridge, Massachusetts 02142, United States., Quang PQ; Bristol Myers Squibb Research & Early Development, 100 Binney Street, Cambridge, Massachusetts 02142, United States., Guo Q; Bristol Myers Squibb Research & Early Development, 100 Binney Street, Cambridge, Massachusetts 02142, United States., Ball DJ; Bristol Myers Squibb Research & Early Development, Princeton, New Jersey 08543, United States., Donnell AF; Bristol Myers Squibb Research & Early Development, Princeton, New Jersey 08543, United States., Mahon BP; Bristol Myers Squibb Research & Early Development, Princeton, New Jersey 08543, United States., Mulligan D; Bristol Myers Squibb Research & Early Development, Princeton, New Jersey 08543, United States., Spronk SA; Bristol Myers Squibb Research & Early Development, Princeton, New Jersey 08543, United States., Srivastava S; Bristol Myers Squibb Research & Early Development, Princeton, New Jersey 08543, United States., Vik EC; Bristol Myers Squibb Research & Early Development, 100 Binney Street, Cambridge, Massachusetts 02142, United States., Cavallaro CL; Bristol Myers Squibb Research & Early Development, Princeton, New Jersey 08543, United States., Chattergoon FJ; Bristol Myers Squibb Research & Early Development, 100 Binney Street, Cambridge, Massachusetts 02142, United States., Ellsworth BA; Bristol Myers Squibb Research & Early Development, Princeton, New Jersey 08543, United States., Joshi S; Bristol Myers Squibb Research & Early Development, 100 Binney Street, Cambridge, Massachusetts 02142, United States., Lees E; Bristol Myers Squibb Research & Early Development, 100 Binney Street, Cambridge, Massachusetts 02142, United States., Lawrence RM; Bristol Myers Squibb Research & Early Development, Princeton, New Jersey 08543, United States., Li L; Bristol Myers Squibb Research & Early Development, Princeton, New Jersey 08543, United States., Mai S; Bristol Myers Squibb Research & Early Development, Princeton, New Jersey 08543, United States., Manik MK; Bristol Myers Squibb Research & Early Development, Princeton, New Jersey 08543, United States., Marsilio F; Bristol Myers Squibb Research & Early Development, Princeton, New Jersey 08543, United States., Mavrakis K; Bristol Myers Squibb Research & Early Development, 100 Binney Street, Cambridge, Massachusetts 02142, United States., Murugan P; Bristol Myers Squibb Research & Early Development, 100 Binney Street, Cambridge, Massachusetts 02142, United States., Newitt JA; Bristol Myers Squibb Research & Early Development, Princeton, New Jersey 08543, United States., Sheth P; Bristol Myers Squibb Research & Early Development, Princeton, New Jersey 08543, United States., Tredup J; Bristol Myers Squibb Research & Early Development, Princeton, New Jersey 08543, United States., Traeger SC; Bristol Myers Squibb Research & Early Development, Princeton, New Jersey 08543, United States., Weis DD; Bristol Myers Squibb Research & Early Development, Princeton, New Jersey 08543, United States., Yan C; Bristol Myers Squibb Research & Early Development, Princeton, New Jersey 08543, United States., Yanchunas J Jr; Bristol Myers Squibb Research & Early Development, Princeton, New Jersey 08543, United States., Zhang P; Bristol Myers Squibb Research & Early Development, Princeton, New Jersey 08543, United States., Wrobleski ST; Bristol Myers Squibb Research & Early Development, Princeton, New Jersey 08543, United States., Kalev P; Bristol Myers Squibb Research & Early Development, 100 Binney Street, Cambridge, Massachusetts 02142, United States., Bronson JJ; Bristol Myers Squibb Research & Early Development, 100 Binney Street, Cambridge, Massachusetts 02142, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2025 Oct 09; Vol. 68 (19), pp. 20827-20845. Date of Electronic Publication: 2025 Sep 25.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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