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A Leishmania virulence factor harnesses an allosteric kinase switch to regulate its ubiquitin ligase activity.

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Title: A Leishmania virulence factor harnesses an allosteric kinase switch to regulate its ubiquitin ligase activity.
Authors: Fokkens TJ; Research Group 'Ubiquitin Signaling Specificity,' Max Planck Institute for Multidisciplinary Sciences, 37077 Göttingen, Germany., Rauh ET; Department of Cell and Developmental Biology, Biocenter, University of Würzburg, 97072 Würzburg, Germany., Wolter M; Research Group 'Ubiquitin Signaling Specificity,' Max Planck Institute for Multidisciplinary Sciences, 37077 Göttingen, Germany., Sebald H; Institut für Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg, 91054 Erlangen, Germany., Mitnacht M; Department of Cell and Developmental Biology, Biocenter, University of Würzburg, 97072 Würzburg, Germany., Ainatzi S; Research Group 'Bioanalytical Mass Spectrometry,' Max Planck Institute for Multidisciplinary Sciences, 37077 Göttingen, Germany; Bioanalytics, University Medical Center, 37075 Göttingen, Germany., Sprick S; Research Group 'Ubiquitin Signaling Specificity,' Max Planck Institute for Multidisciplinary Sciences, 37077 Göttingen, Germany., Teschke L; Institute of Molecular Virology and Cell Biology, Friedrich Loeffler Institute, 17493 Greifswald, Germany., Eisenhuth N; Department of Cell and Developmental Biology, Biocenter, University of Würzburg, 97072 Würzburg, Germany., Huibregtse JM; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA., Butter F; Institute of Molecular Virology and Cell Biology, Friedrich Loeffler Institute, 17493 Greifswald, Germany., Urlaub H; Research Group 'Bioanalytical Mass Spectrometry,' Max Planck Institute for Multidisciplinary Sciences, 37077 Göttingen, Germany; Bioanalytics, University Medical Center, 37075 Göttingen, Germany., Karnkowska A; Institute of Evolutionary Biology, Faculty of Biology, University of Warsaw, 02-089 Warsaw, Poland., Steinchen W; Department of Chemistry, Philipps University Marburg, 35043 Marburg, Germany; Center for Synthetic Microbiology, Philipps University Marburg, 35043 Marburg, Germany., Schleicher U; Institut für Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg, 91054 Erlangen, Germany., Janzen CJ; Department of Cell and Developmental Biology, Biocenter, University of Würzburg, 97072 Würzburg, Germany., Lorenz S; Research Group 'Ubiquitin Signaling Specificity,' Max Planck Institute for Multidisciplinary Sciences, 37077 Göttingen, Germany. Electronic address: sonja.lorenz@mpinat.mpg.de.
Source: Molecular cell [Mol Cell] 2025 Oct 02; Vol. 85 (19), pp. 3711-3728.e11. Date of Electronic Publication: 2025 Sep 24.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE
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  Data: A Leishmania virulence factor harnesses an allosteric kinase switch to regulate its ubiquitin ligase activity.
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  Data: <searchLink fieldCode="AU" term="%22Fokkens+TJ%22">Fokkens TJ</searchLink>; Research Group 'Ubiquitin Signaling Specificity,' Max Planck Institute for Multidisciplinary Sciences, 37077 Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Rauh+ET%22">Rauh ET</searchLink>; Department of Cell and Developmental Biology, Biocenter, University of Würzburg, 97072 Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Wolter+M%22">Wolter M</searchLink>; Research Group 'Ubiquitin Signaling Specificity,' Max Planck Institute for Multidisciplinary Sciences, 37077 Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Sebald+H%22">Sebald H</searchLink>; Institut für Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg, 91054 Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Mitnacht+M%22">Mitnacht M</searchLink>; Department of Cell and Developmental Biology, Biocenter, University of Würzburg, 97072 Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Ainatzi+S%22">Ainatzi S</searchLink>; Research Group 'Bioanalytical Mass Spectrometry,' Max Planck Institute for Multidisciplinary Sciences, 37077 Göttingen, Germany; Bioanalytics, University Medical Center, 37075 Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Sprick+S%22">Sprick S</searchLink>; Research Group 'Ubiquitin Signaling Specificity,' Max Planck Institute for Multidisciplinary Sciences, 37077 Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Teschke+L%22">Teschke L</searchLink>; Institute of Molecular Virology and Cell Biology, Friedrich Loeffler Institute, 17493 Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Eisenhuth+N%22">Eisenhuth N</searchLink>; Department of Cell and Developmental Biology, Biocenter, University of Würzburg, 97072 Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Huibregtse+JM%22">Huibregtse JM</searchLink>; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.<br /><searchLink fieldCode="AU" term="%22Butter+F%22">Butter F</searchLink>; Institute of Molecular Virology and Cell Biology, Friedrich Loeffler Institute, 17493 Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Urlaub+H%22">Urlaub H</searchLink>; Research Group 'Bioanalytical Mass Spectrometry,' Max Planck Institute for Multidisciplinary Sciences, 37077 Göttingen, Germany; Bioanalytics, University Medical Center, 37075 Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Karnkowska+A%22">Karnkowska A</searchLink>; Institute of Evolutionary Biology, Faculty of Biology, University of Warsaw, 02-089 Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Steinchen+W%22">Steinchen W</searchLink>; Department of Chemistry, Philipps University Marburg, 35043 Marburg, Germany; Center for Synthetic Microbiology, Philipps University Marburg, 35043 Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Schleicher+U%22">Schleicher U</searchLink>; Institut für Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg, 91054 Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Janzen+CJ%22">Janzen CJ</searchLink>; Department of Cell and Developmental Biology, Biocenter, University of Würzburg, 97072 Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Lorenz+S%22">Lorenz S</searchLink>; Research Group 'Ubiquitin Signaling Specificity,' Max Planck Institute for Multidisciplinary Sciences, 37077 Göttingen, Germany. Electronic address: sonja.lorenz@mpinat.mpg.de.
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  Data: <searchLink fieldCode="JN" term="%229802571%22">Molecular cell</searchLink> [Mol Cell] 2025 Oct 02; Vol. 85 (19), pp. 3711-3728.e11. <i>Date of Electronic Publication: </i>2025 Sep 24.
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