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SMAD4 induces opposite effects on metastatic growth from pancreatic tumors depending on the organ of residence.

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Title: SMAD4 induces opposite effects on metastatic growth from pancreatic tumors depending on the organ of residence.
Authors: Tsanov KM; Cancer Biology & Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA. ktsanov@uchicago.edu.; Section of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, IL, USA. ktsanov@uchicago.edu.; Ben May Department for Cancer Research, The University of Chicago, Chicago, IL, USA. ktsanov@uchicago.edu., Barriga FM; Cancer Biology & Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Systems Oncology Program, Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain., Ho YJ; Cancer Biology & Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Alonso-Curbelo D; Cancer Biology & Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Institute for Research in Biomedicine (IRB), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain., Livshits G; Cancer Biology & Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Tian S; Cancer Biology & Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Koche RP; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Baslan T; Cancer Biology & Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Biomedical Sciences, School of Veterinary Medicine, The University of Pennsylvania, Philadelphia, PA, USA., Simon J; Cancer Biology & Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Wuest AN; Cancer Biology & Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Reyes J; Cancer Biology & Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Computational & Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Park J; Computational & Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Luan W; Cancer Biology & Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Wilkinson JE; Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI, USA., Bhanot U; Pathology Core Facility, Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Ray-Kirton J; Pathology Core Facility, Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Masilionis I; Computational & Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Dimitrova N; Cancer Biology & Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Iacobuzio-Donahue CA; David M. Rubenstein Center for Pancreatic Cancer Research, Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Chaligné R; Computational & Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Pe'er D; Computational & Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Massagué J; Cancer Biology & Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Lowe SW; Cancer Biology & Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA. lowes@mskcc.org.; Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA. lowes@mskcc.org.
Source: Nature cancer [Nat Cancer] 2025 Nov; Vol. 6 (11), pp. 1839-1856. Date of Electronic Publication: 2025 Sep 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101761119 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-1347 (Electronic) Linking ISSN: 26621347 NLM ISO Abbreviation: Nat Cancer Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Tsanov+KM%22">Tsanov KM</searchLink>; Cancer Biology & Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA. ktsanov@uchicago.edu.; Section of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, IL, USA. ktsanov@uchicago.edu.; Ben May Department for Cancer Research, The University of Chicago, Chicago, IL, USA. ktsanov@uchicago.edu.<br /><searchLink fieldCode="AU" term="%22Barriga+FM%22">Barriga FM</searchLink>; Cancer Biology & Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Systems Oncology Program, Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Ho+YJ%22">Ho YJ</searchLink>; Cancer Biology & Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Alonso-Curbelo+D%22">Alonso-Curbelo D</searchLink>; Cancer Biology & Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Institute for Research in Biomedicine (IRB), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Livshits+G%22">Livshits G</searchLink>; Cancer Biology & Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Tian+S%22">Tian S</searchLink>; Cancer Biology & Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Koche+RP%22">Koche RP</searchLink>; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Baslan+T%22">Baslan T</searchLink>; Cancer Biology & Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Biomedical Sciences, School of Veterinary Medicine, The University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Simon+J%22">Simon J</searchLink>; Cancer Biology & Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Wuest+AN%22">Wuest AN</searchLink>; Cancer Biology & Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Reyes+J%22">Reyes J</searchLink>; Cancer Biology & Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Computational & Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Park+J%22">Park J</searchLink>; Computational & Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Luan+W%22">Luan W</searchLink>; Cancer Biology & Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Wilkinson+JE%22">Wilkinson JE</searchLink>; Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Bhanot+U%22">Bhanot U</searchLink>; Pathology Core Facility, Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Ray-Kirton+J%22">Ray-Kirton J</searchLink>; Pathology Core Facility, Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Masilionis+I%22">Masilionis I</searchLink>; Computational & Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Dimitrova+N%22">Dimitrova N</searchLink>; Cancer Biology & Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Iacobuzio-Donahue+CA%22">Iacobuzio-Donahue CA</searchLink>; David M. Rubenstein Center for Pancreatic Cancer Research, Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Chaligné+R%22">Chaligné R</searchLink>; Computational & Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Pe'er+D%22">Pe'er D</searchLink>; Computational & Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Massagué+J%22">Massagué J</searchLink>; Cancer Biology & Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Lowe+SW%22">Lowe SW</searchLink>; Cancer Biology & Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA. lowes@mskcc.org.; Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA. lowes@mskcc.org.
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  Data: <searchLink fieldCode="JN" term="%22101761119%22">Nature cancer</searchLink> [Nat Cancer] 2025 Nov; Vol. 6 (11), pp. 1839-1856. <i>Date of Electronic Publication: </i>2025 Sep 25.
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