View in EDS HTML Full Text PDF Full Text

Evaluation and Mitigation of Time-Dependent Confounding Effects in Conventional Exposure-Response Analyses for Oncology Drugs.

Saved in:
Bibliographic Details
Title: Evaluation and Mitigation of Time-Dependent Confounding Effects in Conventional Exposure-Response Analyses for Oncology Drugs.
Authors: Yin X; Center for Pharmacometrics and Systems Pharmacology, Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando, Florida, USA., Xiong Y; Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA., Bi Y; Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA., Wei X; Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA., Zhao H; Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA., Fletcher EP; Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA., Madabushi R; Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA., Ayyoub A; Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA., Zhu H; Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA., Schmidt S; Center for Pharmacometrics and Systems Pharmacology, Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando, Florida, USA., Liu J; Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA.
Source: CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2025 Dec; Vol. 14 (12), pp. 2118-2127. Date of Electronic Publication: 2025 Sep 25.
Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 101580011 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2163-8306 (Electronic) Linking ISSN: 21638306 NLM ISO Abbreviation: CPT Pharmacometrics Syst Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 40999649
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Evaluation and Mitigation of Time-Dependent Confounding Effects in Conventional Exposure-Response Analyses for Oncology Drugs.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Yin+X%22">Yin X</searchLink>; Center for Pharmacometrics and Systems Pharmacology, Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Xiong+Y%22">Xiong Y</searchLink>; Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Bi+Y%22">Bi Y</searchLink>; Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Wei+X%22">Wei X</searchLink>; Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+H%22">Zhao H</searchLink>; Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Fletcher+EP%22">Fletcher EP</searchLink>; Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Madabushi+R%22">Madabushi R</searchLink>; Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Ayyoub+A%22">Ayyoub A</searchLink>; Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Zhu+H%22">Zhu H</searchLink>; Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Schmidt+S%22">Schmidt S</searchLink>; Center for Pharmacometrics and Systems Pharmacology, Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101580011%22">CPT: pharmacometrics & systems pharmacology</searchLink> [CPT Pharmacometrics Syst Pharmacol] 2025 Dec; Vol. 14 (12), pp. 2118-2127. <i>Date of Electronic Publication: </i>2025 Sep 25.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley%22">Wiley </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101580011 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2163-8306 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2221638306%22">21638306 </searchLink><i>NLM ISO Abbreviation: </i>CPT Pharmacometrics Syst Pharmacol <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40999649
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1002/psp4.70119
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 2118
    Titles:
      – TitleFull: Evaluation and Mitigation of Time-Dependent Confounding Effects in Conventional Exposure-Response Analyses for Oncology Drugs.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Yin X
      – PersonEntity:
          Name:
            NameFull: Xiong Y
      – PersonEntity:
          Name:
            NameFull: Bi Y
      – PersonEntity:
          Name:
            NameFull: Wei X
      – PersonEntity:
          Name:
            NameFull: Zhao H
      – PersonEntity:
          Name:
            NameFull: Fletcher EP
      – PersonEntity:
          Name:
            NameFull: Madabushi R
      – PersonEntity:
          Name:
            NameFull: Ayyoub A
      – PersonEntity:
          Name:
            NameFull: Zhu H
      – PersonEntity:
          Name:
            NameFull: Schmidt S
      – PersonEntity:
          Name:
            NameFull: Liu J
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 12
              Text: 2025 Dec
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 2163-8306
          Numbering:
            – Type: volume
              Value: 14
            – Type: issue
              Value: 12
          Titles:
            – TitleFull: CPT: pharmacometrics & systems pharmacology
              Type: main
ResultId 1