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Mevalonate Biosynthesis is a Metabolic Vulnerability of Gemcitabine-resistant Pancreatic Cancer.

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Title: Mevalonate Biosynthesis is a Metabolic Vulnerability of Gemcitabine-resistant Pancreatic Cancer.
Authors: Beutel AK; Department of Molecular Biology and Biochemistry University of California Irvine, Irvine, USA.; Department of Internal Medicine I, University Hospital Ulm, Ulm, Germany., Calderon S; Department of Molecular Biology and Biochemistry University of California Irvine, Irvine, USA., Nghiem E; Department of Molecular Biology and Biochemistry University of California Irvine, Irvine, USA., Gulay K; Department of Surgery, University of California San Diego, La Jolla, USA., Santana LPS; West of Scotland HPB Unit, Glasgow Royal Infirmary, Glasgow G61 1QH, UK.; School of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, UK., Zimmer E; Institute of Molecular Oncology and Stem Cell Biology, University Hospital Ulm, Ulm, Germany., Singh R; Department of Molecular Biology and Biochemistry University of California Irvine, Irvine, USA., Anaraki C; Department of Molecular Biology and Biochemistry University of California Irvine, Irvine, USA., Yousefian N; Department of Molecular Biology and Biochemistry University of California Irvine, Irvine, USA., Allgöwer C; Institute of Molecular Oncology and Stem Cell Biology, University Hospital Ulm, Ulm, Germany., Tong G; Department of Pharmaceutical Sciences University of California Irvine, Irvine, USA., Geller C; Department of Developmental and Cell Biology University of California Irvine, Irvine, USA., Chao A; Department of Biological Chemistry University of California Irvine, Irvine, USA., Juarez D; Department of Molecular Biology and Biochemistry University of California Irvine, Irvine, USA., Seufferlein T; Department of Internal Medicine I, University Hospital Ulm, Ulm, Germany., Muir A; Ben May Department for Cancer Research University of Chicago, Chicago, USA., Jang C; Department of Biological Chemistry University of California Irvine, Irvine, USA.; Chao Family Comprehensive Cancer Center, University of California Irvine, USA., Edinger AL; Department of Pharmaceutical Sciences University of California Irvine, Irvine, USA.; Department of Developmental and Cell Biology University of California Irvine, Irvine, USA.; Chao Family Comprehensive Cancer Center, University of California Irvine, USA., Seldin M; Department of Biological Chemistry University of California Irvine, Irvine, USA., Martinez TF; Department of Pharmaceutical Sciences University of California Irvine, Irvine, USA.; Chao Family Comprehensive Cancer Center, University of California Irvine, USA., Kleger A; Institute of Molecular Oncology and Stem Cell Biology, University Hospital Ulm, Ulm, Germany.; Division of Interdisciplinary Pancreatology, Department of Internal Medicine I, University Hospital Ulm, Ulm, Germany., Chang DK; West of Scotland HPB Unit, Glasgow Royal Infirmary, Glasgow G61 1QH, UK.; School of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, UK., Tiriac H; Department of Surgery, University of California San Diego, La Jolla, USA., Valerin JB; Chao Family Comprehensive Cancer Center, University of California Irvine, USA.; Department of Medicine, Division of Hematology and Oncology, University of California Irvine, Orange, USA., Fruman DA; Department of Molecular Biology and Biochemistry University of California Irvine, Irvine, USA.; Chao Family Comprehensive Cancer Center, University of California Irvine, USA., Halbrook CJ; Department of Molecular Biology and Biochemistry University of California Irvine, Irvine, USA.; Chao Family Comprehensive Cancer Center, University of California Irvine, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Sep 20. Date of Electronic Publication: 2025 Sep 20.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Mevalonate Biosynthesis is a Metabolic Vulnerability of Gemcitabine-resistant Pancreatic Cancer.
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  Data: <searchLink fieldCode="AU" term="%22Beutel+AK%22">Beutel AK</searchLink>; Department of Molecular Biology and Biochemistry University of California Irvine, Irvine, USA.; Department of Internal Medicine I, University Hospital Ulm, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Calderon+S%22">Calderon S</searchLink>; Department of Molecular Biology and Biochemistry University of California Irvine, Irvine, USA.<br /><searchLink fieldCode="AU" term="%22Nghiem+E%22">Nghiem E</searchLink>; Department of Molecular Biology and Biochemistry University of California Irvine, Irvine, USA.<br /><searchLink fieldCode="AU" term="%22Gulay+K%22">Gulay K</searchLink>; Department of Surgery, University of California San Diego, La Jolla, USA.<br /><searchLink fieldCode="AU" term="%22Santana+LPS%22">Santana LPS</searchLink>; West of Scotland HPB Unit, Glasgow Royal Infirmary, Glasgow G61 1QH, UK.; School of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, UK.<br /><searchLink fieldCode="AU" term="%22Zimmer+E%22">Zimmer E</searchLink>; Institute of Molecular Oncology and Stem Cell Biology, University Hospital Ulm, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Singh+R%22">Singh R</searchLink>; Department of Molecular Biology and Biochemistry University of California Irvine, Irvine, USA.<br /><searchLink fieldCode="AU" term="%22Anaraki+C%22">Anaraki C</searchLink>; Department of Molecular Biology and Biochemistry University of California Irvine, Irvine, USA.<br /><searchLink fieldCode="AU" term="%22Yousefian+N%22">Yousefian N</searchLink>; Department of Molecular Biology and Biochemistry University of California Irvine, Irvine, USA.<br /><searchLink fieldCode="AU" term="%22Allgöwer+C%22">Allgöwer C</searchLink>; Institute of Molecular Oncology and Stem Cell Biology, University Hospital Ulm, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Tong+G%22">Tong G</searchLink>; Department of Pharmaceutical Sciences University of California Irvine, Irvine, USA.<br /><searchLink fieldCode="AU" term="%22Geller+C%22">Geller C</searchLink>; 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Department of Pharmaceutical Sciences University of California Irvine, Irvine, USA.; Department of Developmental and Cell Biology University of California Irvine, Irvine, USA.; Chao Family Comprehensive Cancer Center, University of California Irvine, USA.<br /><searchLink fieldCode="AU" term="%22Seldin+M%22">Seldin M</searchLink>; Department of Biological Chemistry University of California Irvine, Irvine, USA.<br /><searchLink fieldCode="AU" term="%22Martinez+TF%22">Martinez TF</searchLink>; Department of Pharmaceutical Sciences University of California Irvine, Irvine, USA.; Chao Family Comprehensive Cancer Center, University of California Irvine, USA.<br /><searchLink fieldCode="AU" term="%22Kleger+A%22">Kleger A</searchLink>; Institute of Molecular Oncology and Stem Cell Biology, University Hospital Ulm, Ulm, Germany.; Division of Interdisciplinary Pancreatology, Department of Internal Medicine I, University Hospital Ulm, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Chang+DK%22">Chang DK</searchLink>; West of Scotland HPB Unit, Glasgow Royal Infirmary, Glasgow G61 1QH, UK.; School of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, UK.<br /><searchLink fieldCode="AU" term="%22Tiriac+H%22">Tiriac H</searchLink>; Department of Surgery, University of California San Diego, La Jolla, USA.<br /><searchLink fieldCode="AU" term="%22Valerin+JB%22">Valerin JB</searchLink>; Chao Family Comprehensive Cancer Center, University of California Irvine, USA.; Department of Medicine, Division of Hematology and Oncology, University of California Irvine, Orange, USA.<br /><searchLink fieldCode="AU" term="%22Fruman+DA%22">Fruman DA</searchLink>; Department of Molecular Biology and Biochemistry University of California Irvine, Irvine, USA.; Chao Family Comprehensive Cancer Center, University of California Irvine, USA.<br /><searchLink fieldCode="AU" term="%22Halbrook+CJ%22">Halbrook CJ</searchLink>; Department of Molecular Biology and Biochemistry University of California Irvine, Irvine, USA.; Chao Family Comprehensive Cancer Center, University of California Irvine, USA.
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