I-BET151 modulates glucokinase gene expression and beta cell function in part through changes in FOXO1 expression.
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| Title: | I-BET151 modulates glucokinase gene expression and beta cell function in part through changes in FOXO1 expression. |
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| Authors: | Ho QWC; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Republic of Singapore., Miller JA; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Republic of Singapore., Gunaseelan D; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Republic of Singapore., Chelliah R; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Republic of Singapore., Babu HJ; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Republic of Singapore.; Department of Laboratory Medicine, All India Institute of Medical Sciences, New Delhi, India., Chew XY; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Republic of Singapore., Devaraj S; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Republic of Singapore., Tay VS; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Republic of Singapore.; Nucleic Acid Therapeutics Initiative (NATi), Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore., Kong D; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore.; Department of Biochemistry; Department of Medicine; Precision Medicine Translational Research Programme (TRP); Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore., Wang X; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Republic of Singapore., Tan DY; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Republic of Singapore., Rutter GA; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Republic of Singapore.; Centre de Recherche du CHUM, Faculté de Médicine, Université de Montréal, Montréal, QC, Canada.; Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK.; Research Institute of the McGill University Health Centre, Montréal, QC, Canada., Lee B; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Republic of Singapore., Teo AKK; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore.; Department of Biochemistry; Department of Medicine; Precision Medicine Translational Research Programme (TRP); Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore., Ali Y; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Republic of Singapore. Yusuf.ali@ntu.edu.sg.; Clinical Research Unit, Khoo Teck Puat Hospital, National Healthcare Group, Singapore, Republic of Singapore. Yusuf.ali@ntu.edu.sg. |
| Source: | Diabetologia [Diabetologia] 2025 Dec; Vol. 68 (12), pp. 2767-2780. Date of Electronic Publication: 2025 Sep 26. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0006777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0428 (Electronic) Linking ISSN: 0012186X NLM ISO Abbreviation: Diabetologia Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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