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Design of a potent interleukin-21 mimic for cancer immunotherapy.

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Title: Design of a potent interleukin-21 mimic for cancer immunotherapy.
Authors: Chun JH; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Department of Biochemistry, University of Washington School of Medicine, Seattle, WA, USA.; Graduate Program in Biological Physics, Structure and Design, University of Washington, Seattle, WA, USA., Lim BS; Department of Medicine, Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, USA.; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA., Roy S; Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Walsh MJ; Department of Medicine, Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, USA.; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA., Abhiraman GC; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Zhangxu K; Department of Medicine, Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, USA.; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA., Atajanova T; Department of Medicine, Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, USA.; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA., Revach OY; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Clark EC; Department of Bioengineering and Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA., Li P; Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Palin CA; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Khanna A; Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA, USA., Tower S; Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA, USA., Kureshi R; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Immunology, Harvard Medical School, Boston, MA, USA., Hoffman MT; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Immunology, Harvard Medical School, Boston, MA, USA., Sharova T; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.; Department of Surgery, Massachusetts General Hospital, Boston, MA, USA., Lawless A; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.; Department of Surgery, Massachusetts General Hospital, Boston, MA, USA., Cohen S; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.; Department of Surgery, Massachusetts General Hospital, Boston, MA, USA., Boland GM; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.; Department of Surgery, Massachusetts General Hospital, Boston, MA, USA., Nguyen T; Institute for Protein Design, University of Washington, Seattle, WA, USA., Peprah F; Department of Medicine, Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, USA.; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA., Tello JG; Department of Medicine, Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, USA.; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA., Liu SY; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA., Kim CJ; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Department of Biochemistry, University of Washington School of Medicine, Seattle, WA, USA., Shin H; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Department of Biochemistry, University of Washington School of Medicine, Seattle, WA, USA., Quijano-Rubio A; Institute for Protein Design, University of Washington, Seattle, WA, USA., Jude KM; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Gerben S; Institute for Protein Design, University of Washington, Seattle, WA, USA., Murray A; Institute for Protein Design, University of Washington, Seattle, WA, USA., Heine P; Institute for Protein Design, University of Washington, Seattle, WA, USA., DeWitt M; Institute for Protein Design, University of Washington, Seattle, WA, USA., Ulge UY; Institute for Protein Design, University of Washington, Seattle, WA, USA., Carter L; Institute for Protein Design, University of Washington, Seattle, WA, USA., King NP; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Department of Biochemistry, University of Washington School of Medicine, Seattle, WA, USA., Silva DA; Institute for Protein Design, University of Washington, Seattle, WA, USA., Kueh HY; Department of Bioengineering and Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA., Kalia V; Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA, USA.; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA., Sarkar S; Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA, USA.; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA.; Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA., Jenkins RW; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Garcia KC; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA., Leonard WJ; Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Dougan M; Department of Medicine, Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Dougan SK; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Immunology, Harvard Medical School, Boston, MA, USA., Baker D; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Department of Biochemistry, University of Washington School of Medicine, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, MA, USA.
Source: Science immunology [Sci Immunol] 2025 Sep 26; Vol. 10 (111), pp. eadx1582. Date of Electronic Publication: 2025 Sep 26.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101688624 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2470-9468 (Electronic) Linking ISSN: 24709468 NLM ISO Abbreviation: Sci Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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