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Nanomedicine targeting PPAR in adipose tissue macrophages improves lipid metabolism and obesity-induced metabolic dysfunction.

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Title: Nanomedicine targeting PPAR in adipose tissue macrophages improves lipid metabolism and obesity-induced metabolic dysfunction.
Authors: Applegate CC; Department of Animal Sciences, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.; Department of Bioengineering, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.; The Beckman Institute of Advanced Science and Technology, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA., Kang Y; Division of Nutritional Sciences, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA., Deng H; Department of Bioengineering, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.; Micro and Nanotechnology Laboratory, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA., Chen D; Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA., Gonzalez Medina NY; Department of Bioengineering, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA., Cui Y; Department of Bioengineering, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.; Micro and Nanotechnology Laboratory, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA., Feng Y; Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA., Kuo CW; Department of Bioengineering, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.; Micro and Nanotechnology Laboratory, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA., Shahoei SH; Department of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.; The Jackson Laboratory, Farmington, CT 06032, USA., Kim H; Department of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA., Vidana Gamage HE; Department of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA., Wallig MA; Department of Pathobiology, College of Veterinary Medicine, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.; Department of Veterinary Clinical Medicine, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA., Nelson ER; Division of Nutritional Sciences, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.; Department of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.; Cancer Center at Illinois, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.; Carl R. Woese Institute for Genomic Biology, Anticancer Discovery from Pets to People Theme, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA., Swanson KS; Department of Animal Sciences, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.; Division of Nutritional Sciences, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.; Department of Veterinary Clinical Medicine, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA., Smith AM; Department of Bioengineering, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.; Division of Nutritional Sciences, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.; Micro and Nanotechnology Laboratory, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.; Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.; Cancer Center at Illinois, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.; Carl R. Woese Institute for Genomic Biology, Anticancer Discovery from Pets to People Theme, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.; Carle Illinois College of Medicine, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.
Source: Science advances [Sci Adv] 2025 Sep 26; Vol. 11 (39), pp. eads3731. Date of Electronic Publication: 2025 Sep 26.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Applegate+CC%22">Applegate CC</searchLink>; Department of Animal Sciences, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.; Department of Bioengineering, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.; The Beckman Institute of Advanced Science and Technology, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.<br /><searchLink fieldCode="AU" term="%22Kang+Y%22">Kang Y</searchLink>; Division of Nutritional Sciences, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.<br /><searchLink fieldCode="AU" term="%22Deng+H%22">Deng H</searchLink>; Department of Bioengineering, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.; Micro and Nanotechnology Laboratory, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.<br /><searchLink fieldCode="AU" term="%22Chen+D%22">Chen D</searchLink>; Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.<br /><searchLink fieldCode="AU" term="%22Gonzalez+Medina+NY%22">Gonzalez Medina NY</searchLink>; Department of Bioengineering, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.<br /><searchLink fieldCode="AU" term="%22Cui+Y%22">Cui Y</searchLink>; Department of Bioengineering, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.; Micro and Nanotechnology Laboratory, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.<br /><searchLink fieldCode="AU" term="%22Feng+Y%22">Feng Y</searchLink>; Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.<br /><searchLink fieldCode="AU" term="%22Kuo+CW%22">Kuo CW</searchLink>; Department of Bioengineering, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.; Micro and Nanotechnology Laboratory, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.<br /><searchLink fieldCode="AU" term="%22Shahoei+SH%22">Shahoei SH</searchLink>; Department of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.; The Jackson Laboratory, Farmington, CT 06032, USA.<br /><searchLink fieldCode="AU" term="%22Kim+H%22">Kim H</searchLink>; Department of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.<br /><searchLink fieldCode="AU" term="%22Vidana+Gamage+HE%22">Vidana Gamage HE</searchLink>; Department of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.<br /><searchLink fieldCode="AU" term="%22Wallig+MA%22">Wallig MA</searchLink>; Department of Pathobiology, College of Veterinary Medicine, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.; Department of Veterinary Clinical Medicine, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.<br /><searchLink fieldCode="AU" term="%22Nelson+ER%22">Nelson ER</searchLink>; Division of Nutritional Sciences, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.; Department of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.; Cancer Center at Illinois, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.; Carl R. Woese Institute for Genomic Biology, Anticancer Discovery from Pets to People Theme, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.<br /><searchLink fieldCode="AU" term="%22Swanson+KS%22">Swanson KS</searchLink>; Department of Animal Sciences, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.; Division of Nutritional Sciences, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.; Department of Veterinary Clinical Medicine, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.<br /><searchLink fieldCode="AU" term="%22Smith+AM%22">Smith AM</searchLink>; Department of Bioengineering, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.; Division of Nutritional Sciences, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.; Micro and Nanotechnology Laboratory, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.; Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.; Cancer Center at Illinois, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.; Carl R. Woese Institute for Genomic Biology, Anticancer Discovery from Pets to People Theme, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.; Carle Illinois College of Medicine, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.
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