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Spatially-restricted inflammation-induced senescent-like glia in multiple sclerosis and patient-derived organoids.

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Title: Spatially-restricted inflammation-induced senescent-like glia in multiple sclerosis and patient-derived organoids.
Authors: Fagiani F; Translational Neuropathology Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy., Pedrini E; Translational Neuropathology Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy., Martire MS; Translational Neuropathology Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Neurology Unit, IRCCS San Raffaele Hospital, Milan, Italy., Gastoldi G; Translational Neuropathology Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy., Vanden Bulcke C; Louvain Neuroinflammation Imaging Lab, Institute of NeuroScience, Université Catholique de Louvain, Brussels, Belgium., Lin JP; Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Maric D; Flow and Imaging Cytometry Core Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Brambilla E; Neuroimmunology Unit, Division of Neuroscience, IRCCS San Raffaele Hospital, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy., Ruffini F; Neuroimmunology Unit, Division of Neuroscience, IRCCS San Raffaele Hospital, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy., Peri C; Neuroimmunology Unit, Division of Neuroscience, IRCCS San Raffaele Hospital, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy., Calabresi PA; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA., Maggi P; Louvain Neuroinflammation Imaging Lab, Institute of NeuroScience, Université Catholique de Louvain, Brussels, Belgium., Panina-Bordignon P; Neuroimmunology Unit, Division of Neuroscience, IRCCS San Raffaele Hospital, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy., Martino G; Neuroimmunology Unit, Division of Neuroscience, IRCCS San Raffaele Hospital, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy., Reich DS; Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Absinta M; Department of Biomedical Sciences, Humanitas University, Milan, Italy. martina.absinta@hunimed.eu.; Experimental Neuropathology Lab, IRCCS Humanitas Research Hospital, Milan, Italy. martina.absinta@hunimed.eu.
Source: Nature communications [Nat Commun] 2025 Sep 26; Vol. 16 (1), pp. 8477. Date of Electronic Publication: 2025 Sep 26.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Spatially-restricted inflammation-induced senescent-like glia in multiple sclerosis and patient-derived organoids.
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  Data: <searchLink fieldCode="AU" term="%22Fagiani+F%22">Fagiani F</searchLink>; Translational Neuropathology Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Pedrini+E%22">Pedrini E</searchLink>; Translational Neuropathology Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Martire+MS%22">Martire MS</searchLink>; Translational Neuropathology Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Neurology Unit, IRCCS San Raffaele Hospital, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Gastoldi+G%22">Gastoldi G</searchLink>; Translational Neuropathology Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Vanden+Bulcke+C%22">Vanden Bulcke C</searchLink>; Louvain Neuroinflammation Imaging Lab, Institute of NeuroScience, Université Catholique de Louvain, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Lin+JP%22">Lin JP</searchLink>; Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Maric+D%22">Maric D</searchLink>; Flow and Imaging Cytometry Core Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Brambilla+E%22">Brambilla E</searchLink>; Neuroimmunology Unit, Division of Neuroscience, IRCCS San Raffaele Hospital, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Ruffini+F%22">Ruffini F</searchLink>; Neuroimmunology Unit, Division of Neuroscience, IRCCS San Raffaele Hospital, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Peri+C%22">Peri C</searchLink>; Neuroimmunology Unit, Division of Neuroscience, IRCCS San Raffaele Hospital, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Calabresi+PA%22">Calabresi PA</searchLink>; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Maggi+P%22">Maggi P</searchLink>; Louvain Neuroinflammation Imaging Lab, Institute of NeuroScience, Université Catholique de Louvain, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Panina-Bordignon+P%22">Panina-Bordignon P</searchLink>; Neuroimmunology Unit, Division of Neuroscience, IRCCS San Raffaele Hospital, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Martino+G%22">Martino G</searchLink>; Neuroimmunology Unit, Division of Neuroscience, IRCCS San Raffaele Hospital, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Reich+DS%22">Reich DS</searchLink>; Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Absinta+M%22">Absinta M</searchLink>; Department of Biomedical Sciences, Humanitas University, Milan, Italy. martina.absinta@hunimed.eu.; Experimental Neuropathology Lab, IRCCS Humanitas Research Hospital, Milan, Italy. martina.absinta@hunimed.eu.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 Sep 26; Vol. 16 (1), pp. 8477. <i>Date of Electronic Publication: </i>2025 Sep 26.
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