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Dorsomedial striatal neuroinflammation causes excessive goal-directed action control by disrupting astrocyte function.

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Title: Dorsomedial striatal neuroinflammation causes excessive goal-directed action control by disrupting astrocyte function.
Authors: Abiero AR; School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia.; Centre for Neuroscience and Regenerative Medicine, St. Vincent's Centre for Applied Medical Research, St. Vincent's Health Network, Sydney, NSW, Australia.; School of Psychology, Faculty of Science, University of Sydney, Sydney, NSW, Australia., Gladding JM; School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia., Iredale JA; School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.; Brain Neuromodulation Research Program, Hunter Medical Research Institute, New Lambton Heights, Sydney, NSW, Australia., Drury HR; School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.; Brain Neuromodulation Research Program, Hunter Medical Research Institute, New Lambton Heights, Sydney, NSW, Australia., Manning EE; School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.; Brain Neuromodulation Research Program, Hunter Medical Research Institute, New Lambton Heights, Sydney, NSW, Australia., Dayas CV; School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.; Brain Neuromodulation Research Program, Hunter Medical Research Institute, New Lambton Heights, Sydney, NSW, Australia., Dhungana A; School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia.; Centre for Neuroscience and Regenerative Medicine, St. Vincent's Centre for Applied Medical Research, St. Vincent's Health Network, Sydney, NSW, Australia., Ganesan K; School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia.; Centre for Neuroscience and Regenerative Medicine, St. Vincent's Centre for Applied Medical Research, St. Vincent's Health Network, Sydney, NSW, Australia.; School of Psychology, Faculty of Science, University of Sydney, Sydney, NSW, Australia., Turner K; School of Psychology, University of New South Wales, Sydney, NSW, Australia., Becchi S; Decision Neuroscience Laboratory, School of Psychology, University of New South Wales, Sydney, NSW, Australia.; Teva Pharmaceuticals, Sydney, NSW, Australia., Kendig MD; School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia., Nolan C; Decision Neuroscience Laboratory, School of Psychology, University of New South Wales, Sydney, NSW, Australia., Balleine B; Decision Neuroscience Laboratory, School of Psychology, University of New South Wales, Sydney, NSW, Australia., Castorina A; School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia., Cole L; School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia., Clemens KJ; School of Psychology, University of New South Wales, Sydney, NSW, Australia., Bradfield LA; School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia. laura.bradfield@sydney.edu.au.; Centre for Neuroscience and Regenerative Medicine, St. Vincent's Centre for Applied Medical Research, St. Vincent's Health Network, Sydney, NSW, Australia. laura.bradfield@sydney.edu.au.; School of Psychology, Faculty of Science, University of Sydney, Sydney, NSW, Australia. laura.bradfield@sydney.edu.au.
Source: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2026 Jan; Vol. 51 (2), pp. 486-496. Date of Electronic Publication: 2025 Sep 27.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8904907 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1740-634X (Electronic) Linking ISSN: 0893133X NLM ISO Abbreviation: Neuropsychopharmacology Subsets: MEDLINE
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  Data: Dorsomedial striatal neuroinflammation causes excessive goal-directed action control by disrupting astrocyte function.
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  Data: <searchLink fieldCode="AU" term="%22Abiero+AR%22">Abiero AR</searchLink>; School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia.; Centre for Neuroscience and Regenerative Medicine, St. Vincent's Centre for Applied Medical Research, St. Vincent's Health Network, Sydney, NSW, Australia.; School of Psychology, Faculty of Science, University of Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Gladding+JM%22">Gladding JM</searchLink>; School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Iredale+JA%22">Iredale JA</searchLink>; School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.; Brain Neuromodulation Research Program, Hunter Medical Research Institute, New Lambton Heights, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Drury+HR%22">Drury HR</searchLink>; School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.; Brain Neuromodulation Research Program, Hunter Medical Research Institute, New Lambton Heights, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Manning+EE%22">Manning EE</searchLink>; School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.; Brain Neuromodulation Research Program, Hunter Medical Research Institute, New Lambton Heights, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Dayas+CV%22">Dayas CV</searchLink>; School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.; Brain Neuromodulation Research Program, Hunter Medical Research Institute, New Lambton Heights, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Dhungana+A%22">Dhungana A</searchLink>; School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia.; Centre for Neuroscience and Regenerative Medicine, St. Vincent's Centre for Applied Medical Research, St. Vincent's Health Network, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Ganesan+K%22">Ganesan K</searchLink>; School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia.; Centre for Neuroscience and Regenerative Medicine, St. Vincent's Centre for Applied Medical Research, St. Vincent's Health Network, Sydney, NSW, Australia.; School of Psychology, Faculty of Science, University of Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Turner+K%22">Turner K</searchLink>; School of Psychology, University of New South Wales, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Becchi+S%22">Becchi S</searchLink>; Decision Neuroscience Laboratory, School of Psychology, University of New South Wales, Sydney, NSW, Australia.; Teva Pharmaceuticals, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Kendig+MD%22">Kendig MD</searchLink>; School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Nolan+C%22">Nolan C</searchLink>; Decision Neuroscience Laboratory, School of Psychology, University of New South Wales, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Balleine+B%22">Balleine B</searchLink>; Decision Neuroscience Laboratory, School of Psychology, University of New South Wales, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Castorina+A%22">Castorina A</searchLink>; School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Cole+L%22">Cole L</searchLink>; School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Clemens+KJ%22">Clemens KJ</searchLink>; School of Psychology, University of New South Wales, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Bradfield+LA%22">Bradfield LA</searchLink>; School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia. laura.bradfield@sydney.edu.au.; Centre for Neuroscience and Regenerative Medicine, St. Vincent's Centre for Applied Medical Research, St. Vincent's Health Network, Sydney, NSW, Australia. laura.bradfield@sydney.edu.au.; School of Psychology, Faculty of Science, University of Sydney, Sydney, NSW, Australia. laura.bradfield@sydney.edu.au.
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