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Phase II INTEGRIS-PSC trial of bexotegrast, an αvβ6/αvβ1 integrin inhibitor, in primary sclerosing cholangitis.

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Title: Phase II INTEGRIS-PSC trial of bexotegrast, an αvβ6/αvβ1 integrin inhibitor, in primary sclerosing cholangitis.
Authors: Hirschfield GM; The Autoimmune and Rare Liver Disease Programme, Division of Gastroenterology and Hepatology, Toronto General Hospital, Toronto, ON, Canada. Electronic address: Gideon.Hirschfield@uhn.ca., Kowdley KV; Liver Institute Northwest, Seattle, WA, USA; Elson S. Floyd College of Medicine, Washington State University, Seattle, WA, USA., Trivedi PJ; NIHR Birmingham Biomedical Research Centre, Centre for Liver and Gastrointestinal Research, University of Birmingham, Birmingham, UK; Liver Unit, University Hospitals Birmingham, Birmingham, UK., Eksteen B; Aspen Woods Clinic, Calgary, AB, Canada., Hameed B; University of California San Francisco School of Medicine, San Francisco, CA, USA., Vincent C; Liver Unit, Centre hospitalier de l'Université de Montréal (CHUM), Montreal, QC, Canada., Chen T; Department of Medicine, McGill University Health Centre, Montreal, QC, Canada., Goel A; Stanford University, Palo Alto, CA, USA., Reddy KG; Department of Medicine, University of Chicago, Chicago, IL, USA., Orman E; Indiana University School of Medicine, Indianapolis, IN, USA., Joshi D; Institute of Liver Studies, King's College Hospital NHS Foundation Trust, London, UK., Lefebvre ÉA; Pliant Therapeutics, Inc, South San Francisco, CA, USA., Schaub JR; Pliant Therapeutics, Inc, South San Francisco, CA, USA., An MC; Former employees of Pliant Therapeutics, Inc, South San Francisco, CA, USA., Clark A; Former employees of Pliant Therapeutics, Inc, South San Francisco, CA, USA., Barnes CN; Pliant Therapeutics, Inc, South San Francisco, CA, USA., Pencek R; Former employees of Pliant Therapeutics, Inc, South San Francisco, CA, USA., Thorburn D; Sheila Sherlock Liver Centre and UCL Institute for Liver and Digestive Health, London, UK., Montano-Loza AJ; Division of Gastroenterology and Liver Unit, University of Alberta, Edmonton, AB, Canada., Schramm C; University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Bowlus CL; University of California, Davis, Sacramento, CA, USA., Trauner M; Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria., Levy C; Schiff Center for Liver Diseases, University of Miami, Miami, FL, USA.
Source: Journal of hepatology [J Hepatol] 2026 Jan; Vol. 84 (1), pp. 86-98. Date of Electronic Publication: 2025 Sep 26.
Publication Type: Journal Article; Clinical Trial, Phase II; Randomized Controlled Trial; Multicenter Study
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8503886 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0641 (Electronic) Linking ISSN: 01688278 NLM ISO Abbreviation: J Hepatol Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Phase II INTEGRIS-PSC trial of bexotegrast, an α<subscript>v</subscript>β<subscript>6</subscript>/α<subscript>v</subscript>β<subscript>1</subscript> integrin inhibitor, in primary sclerosing cholangitis.
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  Data: <searchLink fieldCode="AU" term="%22Hirschfield+GM%22">Hirschfield GM</searchLink>; The Autoimmune and Rare Liver Disease Programme, Division of Gastroenterology and Hepatology, Toronto General Hospital, Toronto, ON, Canada. Electronic address: Gideon.Hirschfield@uhn.ca.<br /><searchLink fieldCode="AU" term="%22Kowdley+KV%22">Kowdley KV</searchLink>; Liver Institute Northwest, Seattle, WA, USA; Elson S. Floyd College of Medicine, Washington State University, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Trivedi+PJ%22">Trivedi PJ</searchLink>; NIHR Birmingham Biomedical Research Centre, Centre for Liver and Gastrointestinal Research, University of Birmingham, Birmingham, UK; Liver Unit, University Hospitals Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Eksteen+B%22">Eksteen B</searchLink>; Aspen Woods Clinic, Calgary, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Hameed+B%22">Hameed B</searchLink>; University of California San Francisco School of Medicine, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Vincent+C%22">Vincent C</searchLink>; Liver Unit, Centre hospitalier de l'Université de Montréal (CHUM), Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Chen+T%22">Chen T</searchLink>; Department of Medicine, McGill University Health Centre, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Goel+A%22">Goel A</searchLink>; Stanford University, Palo Alto, CA, USA.<br /><searchLink fieldCode="AU" term="%22Reddy+KG%22">Reddy KG</searchLink>; Department of Medicine, University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Orman+E%22">Orman E</searchLink>; Indiana University School of Medicine, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Joshi+D%22">Joshi D</searchLink>; Institute of Liver Studies, King's College Hospital NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Lefebvre+ÉA%22">Lefebvre ÉA</searchLink>; Pliant Therapeutics, Inc, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Schaub+JR%22">Schaub JR</searchLink>; Pliant Therapeutics, Inc, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22An+MC%22">An MC</searchLink>; Former employees of Pliant Therapeutics, Inc, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Clark+A%22">Clark A</searchLink>; Former employees of Pliant Therapeutics, Inc, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Barnes+CN%22">Barnes CN</searchLink>; Pliant Therapeutics, Inc, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Pencek+R%22">Pencek R</searchLink>; Former employees of Pliant Therapeutics, Inc, South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Thorburn+D%22">Thorburn D</searchLink>; Sheila Sherlock Liver Centre and UCL Institute for Liver and Digestive Health, London, UK.<br /><searchLink fieldCode="AU" term="%22Montano-Loza+AJ%22">Montano-Loza AJ</searchLink>; Division of Gastroenterology and Liver Unit, University of Alberta, Edmonton, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Schramm+C%22">Schramm C</searchLink>; University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Bowlus+CL%22">Bowlus CL</searchLink>; University of California, Davis, Sacramento, CA, USA.<br /><searchLink fieldCode="AU" term="%22Trauner+M%22">Trauner M</searchLink>; Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Levy+C%22">Levy C</searchLink>; Schiff Center for Liver Diseases, University of Miami, Miami, FL, USA.
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  Data: <searchLink fieldCode="JN" term="%228503886%22">Journal of hepatology</searchLink> [J Hepatol] 2026 Jan; Vol. 84 (1), pp. 86-98. <i>Date of Electronic Publication: </i>2025 Sep 26.
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  Data: Journal Article; Clinical Trial, Phase II; Randomized Controlled Trial; Multicenter Study
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>8503886 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1600-0641 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201688278%22">01688278 </searchLink><i>NLM ISO Abbreviation: </i>J Hepatol <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.jhep.2025.09.016
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