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Genetic mutations in HSV-1 replication-defective vectors: Implications for their safety in gene therapy applications.

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Title: Genetic mutations in HSV-1 replication-defective vectors: Implications for their safety in gene therapy applications.
Authors: Cattaneo S; Vita-Salute San Raffaele University, Milan, Italy.; IRCCS Neuromed, Pozzilli, Italy., Bettegazzi B; Vita-Salute San Raffaele University, Milan, Italy. bettegazzi.barbara@hsr.it.; Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy. bettegazzi.barbara@hsr.it., Ingusci S; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Verlengia G; Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Department of Neuroscience and Rehabilitation, Section of Pharmacology, University of Ferrara, Ferrara, Italy., Tascini AS; Vita-Salute San Raffaele University, Milan, Italy.; Center for Omics Sciences COSR, BioInformatics Laboratory, San Raffaele Scientific Institute, Milan, Italy., Zucchini S; Department of Neuroscience and Rehabilitation, Section of Pharmacology, University of Ferrara, Ferrara, Italy., Codazzi F; Vita-Salute San Raffaele University, Milan, Italy.; Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy., Morelli MJ; Center for Omics Sciences COSR, BioInformatics Laboratory, San Raffaele Scientific Institute, Milan, Italy., Marzulli M; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Glorioso JC; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Simonato M; Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Department of Neuroscience and Rehabilitation, Section of Pharmacology, University of Ferrara, Ferrara, Italy.
Source: Gene therapy [Gene Ther] 2025 Dec; Vol. 32 (6), pp. 581-593. Date of Electronic Publication: 2025 Sep 28.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9421525 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5462 (Electronic) Linking ISSN: 09697128 NLM ISO Abbreviation: Gene Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Genetic mutations in HSV-1 replication-defective vectors: Implications for their safety in gene therapy applications.
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  Data: <searchLink fieldCode="AU" term="%22Cattaneo+S%22">Cattaneo S</searchLink>; Vita-Salute San Raffaele University, Milan, Italy.; IRCCS Neuromed, Pozzilli, Italy.<br /><searchLink fieldCode="AU" term="%22Bettegazzi+B%22">Bettegazzi B</searchLink>; Vita-Salute San Raffaele University, Milan, Italy. bettegazzi.barbara@hsr.it.; Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy. bettegazzi.barbara@hsr.it.<br /><searchLink fieldCode="AU" term="%22Ingusci+S%22">Ingusci S</searchLink>; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Verlengia+G%22">Verlengia G</searchLink>; Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Department of Neuroscience and Rehabilitation, Section of Pharmacology, University of Ferrara, Ferrara, Italy.<br /><searchLink fieldCode="AU" term="%22Tascini+AS%22">Tascini AS</searchLink>; Vita-Salute San Raffaele University, Milan, Italy.; Center for Omics Sciences COSR, BioInformatics Laboratory, San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Zucchini+S%22">Zucchini S</searchLink>; Department of Neuroscience and Rehabilitation, Section of Pharmacology, University of Ferrara, Ferrara, Italy.<br /><searchLink fieldCode="AU" term="%22Codazzi+F%22">Codazzi F</searchLink>; Vita-Salute San Raffaele University, Milan, Italy.; Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Morelli+MJ%22">Morelli MJ</searchLink>; Center for Omics Sciences COSR, BioInformatics Laboratory, San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Marzulli+M%22">Marzulli M</searchLink>; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Glorioso+JC%22">Glorioso JC</searchLink>; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Simonato+M%22">Simonato M</searchLink>; Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Department of Neuroscience and Rehabilitation, Section of Pharmacology, University of Ferrara, Ferrara, Italy.
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  Data: <searchLink fieldCode="JN" term="%229421525%22">Gene therapy</searchLink> [Gene Ther] 2025 Dec; Vol. 32 (6), pp. 581-593. <i>Date of Electronic Publication: </i>2025 Sep 28.
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              Text: 2025 Dec
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