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A novel multiplex RNAi therapy simultaneously targets Hif1a and Hif2a to defy retinal degeneration in two models of AMD.

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Title: A novel multiplex RNAi therapy simultaneously targets Hif1a and Hif2a to defy retinal degeneration in two models of AMD.
Authors: Ebner LJA; Laboratory for Retinal Cell Biology, Department of Ophthalmology, University Hospital Zurich, University of Zurich, Wagistrasse 14, Schlieren, 8952 Zurich, Switzerland., Imsand C; Laboratory for Retinal Cell Biology, Department of Ophthalmology, University Hospital Zurich, University of Zurich, Wagistrasse 14, Schlieren, 8952 Zurich, Switzerland., Karademir D; Laboratory for Retinal Cell Biology, Department of Ophthalmology, University Hospital Zurich, University of Zurich, Wagistrasse 14, Schlieren, 8952 Zurich, Switzerland., Peters F; Laboratory for Retinal Cell Biology, Department of Ophthalmology, University Hospital Zurich, University of Zurich, Wagistrasse 14, Schlieren, 8952 Zurich, Switzerland., Kiessling E; Laboratory for Retinal Cell Biology, Department of Ophthalmology, University Hospital Zurich, University of Zurich, Wagistrasse 14, Schlieren, 8952 Zurich, Switzerland., Fottner A; Laboratory for Retinal Cell Biology, Department of Ophthalmology, University Hospital Zurich, University of Zurich, Wagistrasse 14, Schlieren, 8952 Zurich, Switzerland., Matter C; Laboratory for Retinal Cell Biology, Department of Ophthalmology, University Hospital Zurich, University of Zurich, Wagistrasse 14, Schlieren, 8952 Zurich, Switzerland., Fajardo DS; Department of Pediatrics, Powell Gene Therapy Center, University of Florida, Gainesville, FL 32601, USA., Merolla L; Laboratory for Retinal Cell Biology, Department of Ophthalmology, University Hospital Zurich, University of Zurich, Wagistrasse 14, Schlieren, 8952 Zurich, Switzerland., Wögenstein GM; Laboratory for Retinal Cell Biology, Department of Ophthalmology, University Hospital Zurich, University of Zurich, Wagistrasse 14, Schlieren, 8952 Zurich, Switzerland., Tsioti I; Laboratory for Retinal Cell Biology, Department of Ophthalmology, University Hospital Zurich, University of Zurich, Wagistrasse 14, Schlieren, 8952 Zurich, Switzerland., Govers LP; Laboratory for Retinal Cell Biology, Department of Ophthalmology, University Hospital Zurich, University of Zurich, Wagistrasse 14, Schlieren, 8952 Zurich, Switzerland., Blaser F; Department of Ophthalmology, University Hospital Zurich, 8091 Zurich, Switzerland., Meneau I; Department of Ophthalmology, University Hospital Zurich, 8091 Zurich, Switzerland., Boye SL; Department of Pediatrics, Division of Cellular and Molecular Therapy, University of Florida, Gainesville, FL 32610, USA., Boye SE; Department of Pediatrics, Division of Cellular and Molecular Therapy, University of Florida, Gainesville, FL 32610, USA., Grimm C; Laboratory for Retinal Cell Biology, Department of Ophthalmology, University Hospital Zurich, University of Zurich, Wagistrasse 14, Schlieren, 8952 Zurich, Switzerland., Samardzija M; Laboratory for Retinal Cell Biology, Department of Ophthalmology, University Hospital Zurich, University of Zurich, Wagistrasse 14, Schlieren, 8952 Zurich, Switzerland. Electronic address: marijana.samardzija@usz.uzh.ch.
Source: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2026 Jan 07; Vol. 34 (1), pp. 348-366. Date of Electronic Publication: 2025 Sep 27.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A novel multiplex RNAi therapy simultaneously targets Hif1a and Hif2a to defy retinal degeneration in two models of AMD.
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  Data: <searchLink fieldCode="AU" term="%22Ebner+LJA%22">Ebner LJA</searchLink>; Laboratory for Retinal Cell Biology, Department of Ophthalmology, University Hospital Zurich, University of Zurich, Wagistrasse 14, Schlieren, 8952 Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Imsand+C%22">Imsand C</searchLink>; Laboratory for Retinal Cell Biology, Department of Ophthalmology, University Hospital Zurich, University of Zurich, Wagistrasse 14, Schlieren, 8952 Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Karademir+D%22">Karademir D</searchLink>; Laboratory for Retinal Cell Biology, Department of Ophthalmology, University Hospital Zurich, University of Zurich, Wagistrasse 14, Schlieren, 8952 Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Peters+F%22">Peters F</searchLink>; Laboratory for Retinal Cell Biology, Department of Ophthalmology, University Hospital Zurich, University of Zurich, Wagistrasse 14, Schlieren, 8952 Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kiessling+E%22">Kiessling E</searchLink>; Laboratory for Retinal Cell Biology, Department of Ophthalmology, University Hospital Zurich, University of Zurich, Wagistrasse 14, Schlieren, 8952 Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Fottner+A%22">Fottner A</searchLink>; Laboratory for Retinal Cell Biology, Department of Ophthalmology, University Hospital Zurich, University of Zurich, Wagistrasse 14, Schlieren, 8952 Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Matter+C%22">Matter C</searchLink>; Laboratory for Retinal Cell Biology, Department of Ophthalmology, University Hospital Zurich, University of Zurich, Wagistrasse 14, Schlieren, 8952 Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Fajardo+DS%22">Fajardo DS</searchLink>; Department of Pediatrics, Powell Gene Therapy Center, University of Florida, Gainesville, FL 32601, USA.<br /><searchLink fieldCode="AU" term="%22Merolla+L%22">Merolla L</searchLink>; Laboratory for Retinal Cell Biology, Department of Ophthalmology, University Hospital Zurich, University of Zurich, Wagistrasse 14, Schlieren, 8952 Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Wögenstein+GM%22">Wögenstein GM</searchLink>; Laboratory for Retinal Cell Biology, Department of Ophthalmology, University Hospital Zurich, University of Zurich, Wagistrasse 14, Schlieren, 8952 Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Tsioti+I%22">Tsioti I</searchLink>; Laboratory for Retinal Cell Biology, Department of Ophthalmology, University Hospital Zurich, University of Zurich, Wagistrasse 14, Schlieren, 8952 Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Govers+LP%22">Govers LP</searchLink>; Laboratory for Retinal Cell Biology, Department of Ophthalmology, University Hospital Zurich, University of Zurich, Wagistrasse 14, Schlieren, 8952 Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Blaser+F%22">Blaser F</searchLink>; Department of Ophthalmology, University Hospital Zurich, 8091 Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Meneau+I%22">Meneau I</searchLink>; Department of Ophthalmology, University Hospital Zurich, 8091 Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Boye+SL%22">Boye SL</searchLink>; Department of Pediatrics, Division of Cellular and Molecular Therapy, University of Florida, Gainesville, FL 32610, USA.<br /><searchLink fieldCode="AU" term="%22Boye+SE%22">Boye SE</searchLink>; Department of Pediatrics, Division of Cellular and Molecular Therapy, University of Florida, Gainesville, FL 32610, USA.<br /><searchLink fieldCode="AU" term="%22Grimm+C%22">Grimm C</searchLink>; Laboratory for Retinal Cell Biology, Department of Ophthalmology, University Hospital Zurich, University of Zurich, Wagistrasse 14, Schlieren, 8952 Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Samardzija+M%22">Samardzija M</searchLink>; Laboratory for Retinal Cell Biology, Department of Ophthalmology, University Hospital Zurich, University of Zurich, Wagistrasse 14, Schlieren, 8952 Zurich, Switzerland. Electronic address: marijana.samardzija@usz.uzh.ch.
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