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Hedgehog signaling activation rescues hypoxia-induced ferroptosis in human brain organoids.

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Title: Hedgehog signaling activation rescues hypoxia-induced ferroptosis in human brain organoids.
Authors: Yi S; Laboratory of Neurological Diseases and Brain Function, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan Province, China.; Institute of Brain Science, Southwest Medical University, Luzhou, Sichuan Province, China., Huang M; Laboratory of Neurological Diseases and Brain Function, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan Province, China.; Institute of Brain Science, Southwest Medical University, Luzhou, Sichuan Province, China., Xian C; Laboratory of Neurological Diseases and Brain Function, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan Province, China.; Institute of Brain Science, Southwest Medical University, Luzhou, Sichuan Province, China., Kong X; Laboratory of Neurological Diseases and Brain Function, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan Province, China.; Institute of Brain Science, Southwest Medical University, Luzhou, Sichuan Province, China., Yin S; Laboratory of Neurological Diseases and Brain Function, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan Province, China.; Institute of Brain Science, Southwest Medical University, Luzhou, Sichuan Province, China., Peng J; Laboratory of Neurological Diseases and Brain Function, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan Province, China.; Institute of Brain Science, Southwest Medical University, Luzhou, Sichuan Province, China.; Department of Neurosurgery, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan Province, China., Li H; Institute for Brain Science and Disease, Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), Chongqing Medical University, Chongqing, China., Jiang Y; Laboratory of Neurological Diseases and Brain Function, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan Province, China.; Institute of Brain Science, Southwest Medical University, Luzhou, Sichuan Province, China.; Department of Neurosurgery, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan Province, China., Xie B; Laboratory of Neurological Diseases and Brain Function, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan Province, China.; Institute of Brain Science, Southwest Medical University, Luzhou, Sichuan Province, China., Xie H; Laboratory of Neurological Diseases and Brain Function, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan Province, China.; Institute of Brain Science, Southwest Medical University, Luzhou, Sichuan Province, China.
Source: Neural regeneration research [Neural Regen Res] 2026 Sep 01; Vol. 21 (9), pp. 4378-4389. Date of Electronic Publication: 2025 Sep 29.
Publication Type: Journal Article
Journal Info: Publisher: Wolters Kluwer Health, Medknow Country of Publication: India NLM ID: 101316351 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1673-5374 (Print) Linking ISSN: 16735374 NLM ISO Abbreviation: Neural Regen Res Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Hedgehog signaling activation rescues hypoxia-induced ferroptosis in human brain organoids.
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  Data: <searchLink fieldCode="AU" term="%22Yi+S%22">Yi S</searchLink>; Laboratory of Neurological Diseases and Brain Function, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan Province, China.; Institute of Brain Science, Southwest Medical University, Luzhou, Sichuan Province, China.<br /><searchLink fieldCode="AU" term="%22Huang+M%22">Huang M</searchLink>; Laboratory of Neurological Diseases and Brain Function, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan Province, China.; Institute of Brain Science, Southwest Medical University, Luzhou, Sichuan Province, China.<br /><searchLink fieldCode="AU" term="%22Xian+C%22">Xian C</searchLink>; Laboratory of Neurological Diseases and Brain Function, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan Province, China.; Institute of Brain Science, Southwest Medical University, Luzhou, Sichuan Province, China.<br /><searchLink fieldCode="AU" term="%22Kong+X%22">Kong X</searchLink>; Laboratory of Neurological Diseases and Brain Function, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan Province, China.; Institute of Brain Science, Southwest Medical University, Luzhou, Sichuan Province, China.<br /><searchLink fieldCode="AU" term="%22Yin+S%22">Yin S</searchLink>; Laboratory of Neurological Diseases and Brain Function, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan Province, China.; Institute of Brain Science, Southwest Medical University, Luzhou, Sichuan Province, China.<br /><searchLink fieldCode="AU" term="%22Peng+J%22">Peng J</searchLink>; Laboratory of Neurological Diseases and Brain Function, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan Province, China.; Institute of Brain Science, Southwest Medical University, Luzhou, Sichuan Province, China.; Department of Neurosurgery, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan Province, China.<br /><searchLink fieldCode="AU" term="%22Li+H%22">Li H</searchLink>; Institute for Brain Science and Disease, Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), Chongqing Medical University, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Jiang+Y%22">Jiang Y</searchLink>; Laboratory of Neurological Diseases and Brain Function, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan Province, China.; Institute of Brain Science, Southwest Medical University, Luzhou, Sichuan Province, China.; Department of Neurosurgery, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan Province, China.<br /><searchLink fieldCode="AU" term="%22Xie+B%22">Xie B</searchLink>; Laboratory of Neurological Diseases and Brain Function, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan Province, China.; Institute of Brain Science, Southwest Medical University, Luzhou, Sichuan Province, China.<br /><searchLink fieldCode="AU" term="%22Xie+H%22">Xie H</searchLink>; Laboratory of Neurological Diseases and Brain Function, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan Province, China.; Institute of Brain Science, Southwest Medical University, Luzhou, Sichuan Province, China.
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  Data: <searchLink fieldCode="JN" term="%22101316351%22">Neural regeneration research</searchLink> [Neural Regen Res] 2026 Sep 01; Vol. 21 (9), pp. 4378-4389. <i>Date of Electronic Publication: </i>2025 Sep 29.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wolters+Kluwer+Health%2C+Medknow%22">Wolters Kluwer Health, Medknow </searchLink><i>Country of Publication: </i>India <i>NLM ID: </i>101316351 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>1673-5374 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216735374%22">16735374 </searchLink><i>NLM ISO Abbreviation: </i>Neural Regen Res <i>Subsets: </i>PubMed not MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41017694
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      – Type: doi
        Value: 10.4103/NRR.NRR-D-25-00338
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      – Code: eng
        Text: English
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      – TitleFull: Hedgehog signaling activation rescues hypoxia-induced ferroptosis in human brain organoids.
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            – D: 01
              M: 09
              Text: 2026 Sep 01
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              Y: 2026
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