Screening of Medicines for Malaria Venture Open Boxes Identifies Potent SARS-CoV‑2 Papain-like Protease (PLpro) Inhibitors.

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Title: Screening of Medicines for Malaria Venture Open Boxes Identifies Potent SARS-CoV‑2 Papain-like Protease (PLpro) Inhibitors.
Authors: Gawriljuk VO; São Carlos Institute of Physics, University of São Paulo, Av. João Dagnone, 1100Jardim Santa Angelina, São Carlos 13563-120, Brazil., Noske GD; São Carlos Institute of Physics, University of São Paulo, Av. João Dagnone, 1100Jardim Santa Angelina, São Carlos 13563-120, Brazil., Fernandes RS; São Carlos Institute of Physics, University of São Paulo, Av. João Dagnone, 1100Jardim Santa Angelina, São Carlos 13563-120, Brazil., Nakamura AM; São Carlos Institute of Physics, University of São Paulo, Av. João Dagnone, 1100Jardim Santa Angelina, São Carlos 13563-120, Brazil., Freire MCLC; São Carlos Institute of Physics, University of São Paulo, Av. João Dagnone, 1100Jardim Santa Angelina, São Carlos 13563-120, Brazil., Godoy MO; São Carlos Institute of Physics, University of São Paulo, Av. João Dagnone, 1100Jardim Santa Angelina, São Carlos 13563-120, Brazil., Bonatto V; São Carlos Institute of Physics, University of São Paulo, Av. João Dagnone, 1100Jardim Santa Angelina, São Carlos 13563-120, Brazil., Chelucci R; São Carlos Institute of Physics, University of São Paulo, Av. João Dagnone, 1100Jardim Santa Angelina, São Carlos 13563-120, Brazil., Andricopulo A; São Carlos Institute of Physics, University of São Paulo, Av. João Dagnone, 1100Jardim Santa Angelina, São Carlos 13563-120, Brazil., Bakowski MA; Calibr-Skaggs Institute for Innovative Medicine, La Jolla, California 92037, United States., Wolff KC; Calibr-Skaggs Institute for Innovative Medicine, La Jolla, California 92037, United States., Riva L; Calibr-Skaggs Institute for Innovative Medicine, La Jolla, California 92037, United States., Burrows JN; MMV Medicines for Malaria Venture, ICC, Route de Pré-Bois 20, Geneva 1215, Switzerland., Wells TNC; MMV Medicines for Malaria Venture, ICC, Route de Pré-Bois 20, Geneva 1215, Switzerland., Laleu B; MMV Medicines for Malaria Venture, ICC, Route de Pré-Bois 20, Geneva 1215, Switzerland., Martins R; Department of Cellular and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14040-900, Brazil.; Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão PretoFCFRP, Universidade de São PauloUSP, Ribeirão Preto, São Paulo 14040-903, Brazil., Souza JP; Department of Cellular and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14040-900, Brazil., Arruda E; Department of Cellular and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14040-900, Brazil., Samby K; Johnson and Johnson Pvt., Ltd., Gurgaon 122003, India., Laskar S; TCG Lifesciences, West Bengal 700091, India., Guido RVC; São Carlos Institute of Physics, University of São Paulo, Av. João Dagnone, 1100Jardim Santa Angelina, São Carlos 13563-120, Brazil., Oliva G; São Carlos Institute of Physics, University of São Paulo, Av. João Dagnone, 1100Jardim Santa Angelina, São Carlos 13563-120, Brazil., Godoy AS; São Carlos Institute of Physics, University of São Paulo, Av. João Dagnone, 1100Jardim Santa Angelina, São Carlos 13563-120, Brazil.; MMV Medicines for Malaria Venture, ICC, Route de Pré-Bois 20, Geneva 1215, Switzerland.
Source: ACS omega [ACS Omega] 2025 Sep 11; Vol. 10 (37), pp. 42711-42724. Date of Electronic Publication: 2025 Sep 11 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101691658 Publication Model: eCollection Cited Medium: Internet ISSN: 2470-1343 (Electronic) Linking ISSN: 24701343 NLM ISO Abbreviation: ACS Omega Subsets: PubMed not MEDLINE
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  Data: Screening of Medicines for Malaria Venture Open Boxes Identifies Potent SARS-CoV‑2 Papain-like Protease (PL<superscript>pro</superscript>) Inhibitors.
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  Data: <searchLink fieldCode="AU" term="%22Gawriljuk+VO%22">Gawriljuk VO</searchLink>; São Carlos Institute of Physics, University of São Paulo, Av. João Dagnone, 1100Jardim Santa Angelina, São Carlos 13563-120, Brazil.<br /><searchLink fieldCode="AU" term="%22Noske+GD%22">Noske GD</searchLink>; São Carlos Institute of Physics, University of São Paulo, Av. João Dagnone, 1100Jardim Santa Angelina, São Carlos 13563-120, Brazil.<br /><searchLink fieldCode="AU" term="%22Fernandes+RS%22">Fernandes RS</searchLink>; São Carlos Institute of Physics, University of São Paulo, Av. João Dagnone, 1100Jardim Santa Angelina, São Carlos 13563-120, Brazil.<br /><searchLink fieldCode="AU" term="%22Nakamura+AM%22">Nakamura AM</searchLink>; São Carlos Institute of Physics, University of São Paulo, Av. João Dagnone, 1100Jardim Santa Angelina, São Carlos 13563-120, Brazil.<br /><searchLink fieldCode="AU" term="%22Freire+MCLC%22">Freire MCLC</searchLink>; São Carlos Institute of Physics, University of São Paulo, Av. João Dagnone, 1100Jardim Santa Angelina, São Carlos 13563-120, Brazil.<br /><searchLink fieldCode="AU" term="%22Godoy+MO%22">Godoy MO</searchLink>; São Carlos Institute of Physics, University of São Paulo, Av. João Dagnone, 1100Jardim Santa Angelina, São Carlos 13563-120, Brazil.<br /><searchLink fieldCode="AU" term="%22Bonatto+V%22">Bonatto V</searchLink>; São Carlos Institute of Physics, University of São Paulo, Av. João Dagnone, 1100Jardim Santa Angelina, São Carlos 13563-120, Brazil.<br /><searchLink fieldCode="AU" term="%22Chelucci+R%22">Chelucci R</searchLink>; São Carlos Institute of Physics, University of São Paulo, Av. João Dagnone, 1100Jardim Santa Angelina, São Carlos 13563-120, Brazil.<br /><searchLink fieldCode="AU" term="%22Andricopulo+A%22">Andricopulo A</searchLink>; São Carlos Institute of Physics, University of São Paulo, Av. João Dagnone, 1100Jardim Santa Angelina, São Carlos 13563-120, Brazil.<br /><searchLink fieldCode="AU" term="%22Bakowski+MA%22">Bakowski MA</searchLink>; Calibr-Skaggs Institute for Innovative Medicine, La Jolla, California 92037, United States.<br /><searchLink fieldCode="AU" term="%22Wolff+KC%22">Wolff KC</searchLink>; Calibr-Skaggs Institute for Innovative Medicine, La Jolla, California 92037, United States.<br /><searchLink fieldCode="AU" term="%22Riva+L%22">Riva L</searchLink>; Calibr-Skaggs Institute for Innovative Medicine, La Jolla, California 92037, United States.<br /><searchLink fieldCode="AU" term="%22Burrows+JN%22">Burrows JN</searchLink>; MMV Medicines for Malaria Venture, ICC, Route de Pré-Bois 20, Geneva 1215, Switzerland.<br /><searchLink fieldCode="AU" term="%22Wells+TNC%22">Wells TNC</searchLink>; MMV Medicines for Malaria Venture, ICC, Route de Pré-Bois 20, Geneva 1215, Switzerland.<br /><searchLink fieldCode="AU" term="%22Laleu+B%22">Laleu B</searchLink>; MMV Medicines for Malaria Venture, ICC, Route de Pré-Bois 20, Geneva 1215, Switzerland.<br /><searchLink fieldCode="AU" term="%22Martins+R%22">Martins R</searchLink>; Department of Cellular and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14040-900, Brazil.; Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão PretoFCFRP, Universidade de São PauloUSP, Ribeirão Preto, São Paulo 14040-903, Brazil.<br /><searchLink fieldCode="AU" term="%22Souza+JP%22">Souza JP</searchLink>; Department of Cellular and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14040-900, Brazil.<br /><searchLink fieldCode="AU" term="%22Arruda+E%22">Arruda E</searchLink>; Department of Cellular and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14040-900, Brazil.<br /><searchLink fieldCode="AU" term="%22Samby+K%22">Samby K</searchLink>; Johnson and Johnson Pvt., Ltd., Gurgaon 122003, India.<br /><searchLink fieldCode="AU" term="%22Laskar+S%22">Laskar S</searchLink>; TCG Lifesciences, West Bengal 700091, India.<br /><searchLink fieldCode="AU" term="%22Guido+RVC%22">Guido RVC</searchLink>; São Carlos Institute of Physics, University of São Paulo, Av. João Dagnone, 1100Jardim Santa Angelina, São Carlos 13563-120, Brazil.<br /><searchLink fieldCode="AU" term="%22Oliva+G%22">Oliva G</searchLink>; São Carlos Institute of Physics, University of São Paulo, Av. João Dagnone, 1100Jardim Santa Angelina, São Carlos 13563-120, Brazil.<br /><searchLink fieldCode="AU" term="%22Godoy+AS%22">Godoy AS</searchLink>; São Carlos Institute of Physics, University of São Paulo, Av. João Dagnone, 1100Jardim Santa Angelina, São Carlos 13563-120, Brazil.; MMV Medicines for Malaria Venture, ICC, Route de Pré-Bois 20, Geneva 1215, Switzerland.
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