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The immunomodulatory and antitumor properties of the bacterial metalloprotease Oligopeptidase A are mediated by TLR4/MyD88/TRIF and MAPK signaling pathways.

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Title: The immunomodulatory and antitumor properties of the bacterial metalloprotease Oligopeptidase A are mediated by TLR4/MyD88/TRIF and MAPK signaling pathways.
Authors: Silva P; Department of Microbiology, Immunology, and Parasitology, Paulista School of Medicine, Federal University of São Paulo (EPM-UNIFESP), São Paulo, Brazil.; Goethe University Frankfurt, Faculty of Medicine, Institute of Clinical Pharmacology, Frankfurt/Main, Germany., Silva GN; Department of Microbiology, Immunology, and Parasitology, Paulista School of Medicine, Federal University of São Paulo (EPM-UNIFESP), São Paulo, Brazil., Melo FM; Department of Microbiology, Immunology, and Parasitology, Paulista School of Medicine, Federal University of São Paulo (EPM-UNIFESP), São Paulo, Brazil.; David Geffen School of Medicine, Department of Microbiology, Immunology, and Molecular Genetics, Los Angeles, CA, United States., de Amat Herbozo C; Department of Microbiology, Immunology, and Parasitology, Paulista School of Medicine, Federal University of São Paulo (EPM-UNIFESP), São Paulo, Brazil., Sellani TA; Department of Microbiology, Immunology, and Parasitology, Paulista School of Medicine, Federal University of São Paulo (EPM-UNIFESP), São Paulo, Brazil.; Glaxosmithkline Brasil, Oncohematology, São Paulo, Brazil., Tomaz SL; Department of Microbiology, Immunology, and Parasitology, Paulista School of Medicine, Federal University of São Paulo (EPM-UNIFESP), São Paulo, Brazil.; Sirio-Libanes Hospital, São Paulo, Brazil., De Melo ACL; Department of Microbiology, Immunology, and Parasitology, Paulista School of Medicine, Federal University of São Paulo (EPM-UNIFESP), São Paulo, Brazil., Da Silva LR; Department of Microbiology, Immunology, and Parasitology, Paulista School of Medicine, Federal University of São Paulo (EPM-UNIFESP), São Paulo, Brazil., Berzaghi R; Department of Microbiology, Immunology, and Parasitology, Paulista School of Medicine, Federal University of São Paulo (EPM-UNIFESP), São Paulo, Brazil.; Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway., Marcondes MFM; Department of Biophysics, Paulista School of Medicine, Federal University of São Paulo (EPM-UNIFESP), São Paulo, Brazil., Bronze F; Department of Biophysics, Paulista School of Medicine, Federal University of São Paulo (EPM-UNIFESP), São Paulo, Brazil., Paschoalin T; Department of Biophysics, Paulista School of Medicine, Federal University of São Paulo (EPM-UNIFESP), São Paulo, Brazil., Glezer I; Department of Biochemistry, Paulista School of Medicine, Federal University of São Paulo (EPM-UNIFESP), São Paulo, Brazil., Carmona AK; Department of Biophysics, Paulista School of Medicine, Federal University of São Paulo (EPM-UNIFESP), São Paulo, Brazil., Pereira FV; Department of Microbiology, Immunology, and Parasitology, Paulista School of Medicine, Federal University of São Paulo (EPM-UNIFESP), São Paulo, Brazil.; Department of Immunology and Microbiology, University of Colorado, Aurora, CO, United States., Rodrigues EG; Department of Microbiology, Immunology, and Parasitology, Paulista School of Medicine, Federal University of São Paulo (EPM-UNIFESP), São Paulo, Brazil.
Source: Frontiers in immunology [Front Immunol] 2025 Sep 12; Vol. 16, pp. 1630886. Date of Electronic Publication: 2025 Sep 12 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The immunomodulatory and antitumor properties of the bacterial metalloprotease Oligopeptidase A are mediated by TLR4/MyD88/TRIF and MAPK signaling pathways.
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