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Systemic and gut microbiome changes with metformin and liraglutide in youth-onset type 2 diabetes: the MIGHTY study.

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Title: Systemic and gut microbiome changes with metformin and liraglutide in youth-onset type 2 diabetes: the MIGHTY study.
Authors: Glaros SB; Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA., Mishra SP; USF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL, USA.; Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA., Jain S; USF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL, USA.; Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA., Davis FS; Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA., Gabel SA; Nuclear Magnetic Resonance Group, National Institute of Environmental Health Sciences, Durham, NC, USA., Mueller GA; Nuclear Magnetic Resonance Group, National Institute of Environmental Health Sciences, Durham, NC, USA., Jarmusch AK; Metabolomics Core Facility, Inflammation, Immunity and Disease Laboratory, National Institute of Environmental Health Sciences, Durham, NC, USA., Mabundo L; Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA., Courville AB; Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA., Walter MF; Clinical Laboratory Services Core, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA., Walter PJ; Clinical Mass Spectrometry Core, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA., Overdahl KE; Metabolomics Core Facility, Inflammation, Immunity and Disease Laboratory, National Institute of Environmental Health Sciences, Durham, NC, USA., Yadav H; USF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL, USA.; Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA., Chung ST; Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.; Division of Diabetes and Endocrinology, Children's National Hospital, Washington, DC, USA.
Source: Gut microbes [Gut Microbes] 2025 Dec; Vol. 17 (1), pp. 2558071. Date of Electronic Publication: 2025 Sep 29.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101495343 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1949-0984 (Electronic) Linking ISSN: 19490976 NLM ISO Abbreviation: Gut Microbes Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Systemic and gut microbiome changes with metformin and liraglutide in youth-onset type 2 diabetes: the MIGHTY study.
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  Data: <searchLink fieldCode="AU" term="%22Glaros+SB%22">Glaros SB</searchLink>; Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Mishra+SP%22">Mishra SP</searchLink>; USF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL, USA.; Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Jain+S%22">Jain S</searchLink>; USF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL, USA.; Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Davis+FS%22">Davis FS</searchLink>; Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Gabel+SA%22">Gabel SA</searchLink>; Nuclear Magnetic Resonance Group, National Institute of Environmental Health Sciences, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Mueller+GA%22">Mueller GA</searchLink>; Nuclear Magnetic Resonance Group, National Institute of Environmental Health Sciences, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Jarmusch+AK%22">Jarmusch AK</searchLink>; Metabolomics Core Facility, Inflammation, Immunity and Disease Laboratory, National Institute of Environmental Health Sciences, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Mabundo+L%22">Mabundo L</searchLink>; Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Courville+AB%22">Courville AB</searchLink>; Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Walter+MF%22">Walter MF</searchLink>; Clinical Laboratory Services Core, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Walter+PJ%22">Walter PJ</searchLink>; Clinical Mass Spectrometry Core, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Overdahl+KE%22">Overdahl KE</searchLink>; Metabolomics Core Facility, Inflammation, Immunity and Disease Laboratory, National Institute of Environmental Health Sciences, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Yadav+H%22">Yadav H</searchLink>; USF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL, USA.; Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA.<br /><searchLink fieldCode="AU" term="%22Chung+ST%22">Chung ST</searchLink>; Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.; Division of Diabetes and Endocrinology, Children's National Hospital, Washington, DC, USA.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Taylor+%26+Francis%22">Taylor & Francis </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101495343 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1949-0984 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219490976%22">19490976 </searchLink><i>NLM ISO Abbreviation: </i>Gut Microbes <i>Subsets: </i>MEDLINE
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