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Hypertonic Saline or Carbocisteine in Bronchiectasis.

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Title: Hypertonic Saline or Carbocisteine in Bronchiectasis.
Authors: Bradley JM; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, United Kingdom., O'Neill B; Institute of Nursing and Health Research, Ulster University, Belfast, UK., McAuley DF; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, United Kingdom., Chalmers JD; Scottish Centre for Respiratory Research, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK., De Soyza A; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle, UK., Hill AT; Royal Infirmary of Edinburgh, Edinburgh.; Department of Respiratory Medicine, Centre for Inflammation Research, University of Edinburgh, Edinburgh., Carroll M; University Hospital Southampton NHS Foundation Trust, Southampton, UK., Loebinger MR; Royal Brompton Hospital, London.; National Heart and Lung Institute, Imperial College, London., Duckers J; University Hospital Llandough Cardiff and Vale University Health Board, Cardiff, UK., Clarke M; Centre for Public Health, Queen's University Belfast, Belfast, UK.; Northern Ireland Clinical Trials Unit, Belfast, UK., McLeese RH; Wellcome Trust-Wolfson Northern Ireland Clinical Research Facility, Queen's University Belfast, Belfast, UK., Ferguson K; Western Health and Social Care Trust, Londonderry, UK.; Belfast Health and Social Care Trust, Belfast, UK., Jackson A; Northern Ireland Clinical Trials Unit, Belfast, UK., Campbell C; Northern Ireland Clinical Trials Unit, Belfast, UK., McDowell C; Northern Ireland Clinical Trials Unit, Belfast, UK., Agus A; Northern Ireland Clinical Trials Unit, Belfast, UK., Norrie J; Centre for Public Health, Queen's University Belfast, Belfast, UK., Copeland F; Primary Ciliary Dyskinesia Family Support Group, Ciliopathy Alliance, London., Downey DG; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, United Kingdom.; Belfast Health and Social Care Trust, Belfast, UK., Convery R; Southern Health and Social Care Trust, Craigavon, UK., Kelly M; Western Health and Social Care Trust, Londonderry, UK., Flight W; Oxford University Hospitals, Oxford, UK., Talbot NP; Oxford University Hospitals, Oxford, UK., Hurst JR; UCL Respiratory, University College London, London., Steer J; Northumbria Healthcare NHS Foundation Trust, Newcastle, UK., Anwar M; Princess Alexandra Hospital, Harlow, UK., Shahidi M; Buckinghamshire Healthcare NHS Trust, Buckingham, UK., Gatheral T; Department of Respiratory Medicine, University Hospitals of Morecambe Bay NHS Foundation Trust, Morecambe, UK., Etumi M; Blackpool Teaching Hospitals NHS Trust, Blackpool, UK., Sullivan AL; University Hospitals Birmingham, Birmingham, UK., Ionescu AA; Royal Gwent Hospital, Newport, UK., Patil V; University Hospitals of Leicester NHS Trust, Leicester, UK., Bhattacharya M; Milton Keynes Hospital NHS Foundation Trust, Milton Keynes, UK., Caskey S; Belfast Health and Social Care Trust, Belfast, UK., Cosgrove D; Southern Health and Social Care Trust, Craigavon, UK., Hagan C; Southern Health and Social Care Trust, Craigavon, UK., Shoemark A; Scottish Centre for Respiratory Research, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK., McManus T; Wellcome Trust-Wolfson Northern Ireland Clinical Research Facility, Queen's University Belfast, Belfast, UK., Davies G; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle, UK., Elborn JS; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, United Kingdom.
Corporate Authors: CLEAR Investigator Team
Source: The New England journal of medicine [N Engl J Med] 2025 Oct 23; Vol. 393 (16), pp. 1565-1577. Date of Electronic Publication: 2025 Sep 28.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study; Comparative Study
Journal Info: Publisher: Massachusetts Medical Society Country of Publication: United States NLM ID: 0255562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1533-4406 (Electronic) Linking ISSN: 00284793 NLM ISO Abbreviation: N Engl J Med Subsets: MEDLINE
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  Data: Hypertonic Saline or Carbocisteine in Bronchiectasis.
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  Data: <searchLink fieldCode="AU" term="%22Bradley+JM%22">Bradley JM</searchLink>; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, United Kingdom.<br /><searchLink fieldCode="AU" term="%22O'Neill+B%22">O'Neill B</searchLink>; Institute of Nursing and Health Research, Ulster University, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22McAuley+DF%22">McAuley DF</searchLink>; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Chalmers+JD%22">Chalmers JD</searchLink>; Scottish Centre for Respiratory Research, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22De+Soyza+A%22">De Soyza A</searchLink>; Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle, UK.<br /><searchLink fieldCode="AU" term="%22Hill+AT%22">Hill AT</searchLink>; Royal Infirmary of Edinburgh, Edinburgh.; Department of Respiratory Medicine, Centre for Inflammation Research, University of Edinburgh, Edinburgh.<br /><searchLink fieldCode="AU" term="%22Carroll+M%22">Carroll M</searchLink>; University Hospital Southampton NHS Foundation Trust, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Loebinger+MR%22">Loebinger MR</searchLink>; Royal Brompton Hospital, London.; National Heart and Lung Institute, Imperial College, London.<br /><searchLink fieldCode="AU" term="%22Duckers+J%22">Duckers J</searchLink>; University Hospital Llandough Cardiff and Vale University Health Board, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Clarke+M%22">Clarke M</searchLink>; Centre for Public Health, Queen's University Belfast, Belfast, UK.; Northern Ireland Clinical Trials Unit, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22McLeese+RH%22">McLeese RH</searchLink>; Wellcome Trust-Wolfson Northern Ireland Clinical Research Facility, Queen's University Belfast, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Ferguson+K%22">Ferguson K</searchLink>; 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Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, United Kingdom.; Belfast Health and Social Care Trust, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Convery+R%22">Convery R</searchLink>; Southern Health and Social Care Trust, Craigavon, UK.<br /><searchLink fieldCode="AU" term="%22Kelly+M%22">Kelly M</searchLink>; Western Health and Social Care Trust, Londonderry, UK.<br /><searchLink fieldCode="AU" term="%22Flight+W%22">Flight W</searchLink>; Oxford University Hospitals, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Talbot+NP%22">Talbot NP</searchLink>; Oxford University Hospitals, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Hurst+JR%22">Hurst JR</searchLink>; UCL Respiratory, University College London, London.<br /><searchLink fieldCode="AU" term="%22Steer+J%22">Steer J</searchLink>; Northumbria Healthcare NHS Foundation Trust, Newcastle, UK.<br /><searchLink fieldCode="AU" term="%22Anwar+M%22">Anwar M</searchLink>; Princess Alexandra Hospital, Harlow, UK.<br /><searchLink fieldCode="AU" term="%22Shahidi+M%22">Shahidi M</searchLink>; 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  Data: <searchLink fieldCode="JN" term="%220255562%22">The New England journal of medicine</searchLink> [N Engl J Med] 2025 Oct 23; Vol. 393 (16), pp. 1565-1577. <i>Date of Electronic Publication: </i>2025 Sep 28.
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