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Effect of the gut microbiota-derived tryptophan metabolite indole-3-acetic acid in pneumonia.

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Title: Effect of the gut microbiota-derived tryptophan metabolite indole-3-acetic acid in pneumonia.
Authors: Kullberg RFJ; Center for Infection and Molecular Medicine (CIMM), Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands. r.f.j.kullberg@amsterdamumc.nl.; Amsterdam institute for Immunology and Infectious diseases, Amsterdam, the Netherlands. r.f.j.kullberg@amsterdamumc.nl., van Linge CCA; Center for Infection and Molecular Medicine (CIMM), Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam institute for Immunology and Infectious diseases, Amsterdam, the Netherlands., Haak BW; Center for Infection and Molecular Medicine (CIMM), Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam institute for Immunology and Infectious diseases, Amsterdam, the Netherlands., Paul PS; Center for Infection and Molecular Medicine (CIMM), Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam institute for Immunology and Infectious diseases, Amsterdam, the Netherlands., Butler JM; Center for Infection and Molecular Medicine (CIMM), Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam institute for Immunology and Infectious diseases, Amsterdam, the Netherlands., Wolff N; Center for Infection and Molecular Medicine (CIMM), Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam institute for Immunology and Infectious diseases, Amsterdam, the Netherlands., van Engelen TSR; Center for Infection and Molecular Medicine (CIMM), Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam institute for Immunology and Infectious diseases, Amsterdam, the Netherlands., Sikkens JJ; Department of Internal Medicine, Section Acute and General Internal Medicine, Amsterdam UMC, Amsterdam, The Netherlands., Bomers MK; Department of Internal Medicine, Division of Infectious Diseases, Amsterdam UMC, Amsterdam, The Netherlands., Lefèvre A; UMR 1253, iBrain, INSERM, University of Tours, Tours, France., Cremer OL; Department of Intensive Care Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Roelofs JJTH; Department of Pathology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., Sovran B; Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology, Endocrinology and Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Department of Paediatric Surgery, Amsterdam Reproduction and Development Research Institute, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Emma Center for Personalized Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., van den Wijngaard R; Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology, Endocrinology and Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., de Vos AF; Center for Infection and Molecular Medicine (CIMM), Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam institute for Immunology and Infectious diseases, Amsterdam, the Netherlands., de Jonge WJ; Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology, Endocrinology and Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Department of General, Visceral, Thoracic and Vascular Surgery, University Hospital Bonn, Bonn, Germany., van der Poll T; Center for Infection and Molecular Medicine (CIMM), Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam institute for Immunology and Infectious diseases, Amsterdam, the Netherlands.; Department of Internal Medicine, Division of Infectious Diseases, Amsterdam UMC, Amsterdam, The Netherlands., Wiersinga WJ; Center for Infection and Molecular Medicine (CIMM), Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam institute for Immunology and Infectious diseases, Amsterdam, the Netherlands.; Department of Internal Medicine, Division of Infectious Diseases, Amsterdam UMC, Amsterdam, The Netherlands.
Source: Nature communications [Nat Commun] 2025 Sep 29; Vol. 16 (1), pp. 8565. Date of Electronic Publication: 2025 Sep 29.
Publication Type: Journal Article; Observational Study
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Effect of the gut microbiota-derived tryptophan metabolite indole-3-acetic acid in pneumonia.
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  Data: <searchLink fieldCode="AU" term="%22Kullberg+RFJ%22">Kullberg RFJ</searchLink>; Center for Infection and Molecular Medicine (CIMM), Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands. r.f.j.kullberg@amsterdamumc.nl.; Amsterdam institute for Immunology and Infectious diseases, Amsterdam, the Netherlands. r.f.j.kullberg@amsterdamumc.nl.<br /><searchLink fieldCode="AU" term="%22van+Linge+CCA%22">van Linge CCA</searchLink>; Center for Infection and Molecular Medicine (CIMM), Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam institute for Immunology and Infectious diseases, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Haak+BW%22">Haak BW</searchLink>; Center for Infection and Molecular Medicine (CIMM), Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam institute for Immunology and Infectious diseases, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Paul+PS%22">Paul PS</searchLink>; Center for Infection and Molecular Medicine (CIMM), Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam institute for Immunology and Infectious diseases, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Butler+JM%22">Butler JM</searchLink>; Center for Infection and Molecular Medicine (CIMM), Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam institute for Immunology and Infectious diseases, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Wolff+N%22">Wolff N</searchLink>; Center for Infection and Molecular Medicine (CIMM), Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam institute for Immunology and Infectious diseases, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Engelen+TSR%22">van Engelen TSR</searchLink>; Center for Infection and Molecular Medicine (CIMM), Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam institute for Immunology and Infectious diseases, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Sikkens+JJ%22">Sikkens JJ</searchLink>; 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Department of Paediatric Surgery, Amsterdam Reproduction and Development Research Institute, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Emma Center for Personalized Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+den+Wijngaard+R%22">van den Wijngaard R</searchLink>; Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology, Endocrinology and Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Vos+AF%22">de Vos AF</searchLink>; Center for Infection and Molecular Medicine (CIMM), Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam institute for Immunology and Infectious diseases, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Jonge+WJ%22">de Jonge WJ</searchLink>; Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology, Endocrinology and Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Department of General, Visceral, Thoracic and Vascular Surgery, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22van+der+Poll+T%22">van der Poll T</searchLink>; Center for Infection and Molecular Medicine (CIMM), Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam institute for Immunology and Infectious diseases, Amsterdam, the Netherlands.; Department of Internal Medicine, Division of Infectious Diseases, Amsterdam UMC, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Wiersinga+WJ%22">Wiersinga WJ</searchLink>; Center for Infection and Molecular Medicine (CIMM), Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam institute for Immunology and Infectious diseases, Amsterdam, the Netherlands.; Department of Internal Medicine, Division of Infectious Diseases, Amsterdam UMC, Amsterdam, The Netherlands.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 Sep 29; Vol. 16 (1), pp. 8565. <i>Date of Electronic Publication: </i>2025 Sep 29.
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