View in EDS

Acetyl-CoA carboxylase 1 inhibition increases Treg metabolism and graft-versus-host disease treatment efficacy via mitochondrial fusion.

Saved in:
Bibliographic Details
Title: Acetyl-CoA carboxylase 1 inhibition increases Treg metabolism and graft-versus-host disease treatment efficacy via mitochondrial fusion.
Authors: McDonald-Hyman C; Division of Hematology/Oncology/Transplantation, Department of Medicine, and., Aguilar EG; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA., Compeer EB; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom., Zaiken MC; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA., Rhee SY; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA., Mohamed FA; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA., Larson JH; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA., Loschi ML; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA., Lees C; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA., Thangavelu G; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA., Sleeth ML; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA., Smith KD; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA., Whangbo JS; Division of Hematology/Oncology, Boston Children's Hospital, Dana-Farber Cancer Institute, and., Ritz J; Division of Hematologic Malignancies, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA., Sparwasser TD; Institute of Medical Microbiology and Hygiene, University Medical Center of the Johannes Gutenberg University, Mainz, Germany., O'Connor RS; Center for Cellular Immunotherapies, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA., Crawford PA; Division of Molecular Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA., Rathmell JC; Vanderbilt Center for Immunobiology, Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Kean LS; Division of Hematology/Oncology, Boston Children's Hospital, Dana-Farber Cancer Institute, and., Zeiser R; Department of Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, Albert Ludwigs University, Freiburg, Germany., Hippen KL; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA., Dustin ML; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom., Blazar BR; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.
Source: The Journal of clinical investigation [J Clin Invest] 2025 Sep 30; Vol. 135 (23). Date of Electronic Publication: 2025 Sep 30 (Print Publication: 2025).
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: eCollection Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 41026528
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Acetyl-CoA carboxylase 1 inhibition increases Treg metabolism and graft-versus-host disease treatment efficacy via mitochondrial fusion.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22McDonald-Hyman+C%22">McDonald-Hyman C</searchLink>; Division of Hematology/Oncology/Transplantation, Department of Medicine, and.<br /><searchLink fieldCode="AU" term="%22Aguilar+EG%22">Aguilar EG</searchLink>; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Compeer+EB%22">Compeer EB</searchLink>; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Zaiken+MC%22">Zaiken MC</searchLink>; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Rhee+SY%22">Rhee SY</searchLink>; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Mohamed+FA%22">Mohamed FA</searchLink>; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Larson+JH%22">Larson JH</searchLink>; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Loschi+ML%22">Loschi ML</searchLink>; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Lees+C%22">Lees C</searchLink>; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Thangavelu+G%22">Thangavelu G</searchLink>; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Sleeth+ML%22">Sleeth ML</searchLink>; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Smith+KD%22">Smith KD</searchLink>; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Whangbo+JS%22">Whangbo JS</searchLink>; Division of Hematology/Oncology, Boston Children's Hospital, Dana-Farber Cancer Institute, and.<br /><searchLink fieldCode="AU" term="%22Ritz+J%22">Ritz J</searchLink>; Division of Hematologic Malignancies, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Sparwasser+TD%22">Sparwasser TD</searchLink>; Institute of Medical Microbiology and Hygiene, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22O'Connor+RS%22">O'Connor RS</searchLink>; Center for Cellular Immunotherapies, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Crawford+PA%22">Crawford PA</searchLink>; Division of Molecular Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Rathmell+JC%22">Rathmell JC</searchLink>; Vanderbilt Center for Immunobiology, Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Kean+LS%22">Kean LS</searchLink>; Division of Hematology/Oncology, Boston Children's Hospital, Dana-Farber Cancer Institute, and.<br /><searchLink fieldCode="AU" term="%22Zeiser+R%22">Zeiser R</searchLink>; Department of Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, Albert Ludwigs University, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Hippen+KL%22">Hippen KL</searchLink>; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Dustin+ML%22">Dustin ML</searchLink>; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Blazar+BR%22">Blazar BR</searchLink>; Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%227802877%22">The Journal of clinical investigation</searchLink> [J Clin Invest] 2025 Sep 30; Vol. 135 (23). <i>Date of Electronic Publication: </i>2025 Sep 30 (<i>Print Publication: </i>2025).
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Society+for+Clinical+Investigation%22">American Society for Clinical Investigation </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7802877 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1558-8238 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200219738%22">00219738 </searchLink><i>NLM ISO Abbreviation: </i>J Clin Invest <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41026528
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1172/JCI182480
    Languages:
      – Code: eng
        Text: English
    Titles:
      – TitleFull: Acetyl-CoA carboxylase 1 inhibition increases Treg metabolism and graft-versus-host disease treatment efficacy via mitochondrial fusion.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: McDonald-Hyman C
      – PersonEntity:
          Name:
            NameFull: Aguilar EG
      – PersonEntity:
          Name:
            NameFull: Compeer EB
      – PersonEntity:
          Name:
            NameFull: Zaiken MC
      – PersonEntity:
          Name:
            NameFull: Rhee SY
      – PersonEntity:
          Name:
            NameFull: Mohamed FA
      – PersonEntity:
          Name:
            NameFull: Larson JH
      – PersonEntity:
          Name:
            NameFull: Loschi ML
      – PersonEntity:
          Name:
            NameFull: Lees C
      – PersonEntity:
          Name:
            NameFull: Thangavelu G
      – PersonEntity:
          Name:
            NameFull: Sleeth ML
      – PersonEntity:
          Name:
            NameFull: Smith KD
      – PersonEntity:
          Name:
            NameFull: Whangbo JS
      – PersonEntity:
          Name:
            NameFull: Ritz J
      – PersonEntity:
          Name:
            NameFull: Sparwasser TD
      – PersonEntity:
          Name:
            NameFull: O'Connor RS
      – PersonEntity:
          Name:
            NameFull: Crawford PA
      – PersonEntity:
          Name:
            NameFull: Rathmell JC
      – PersonEntity:
          Name:
            NameFull: Kean LS
      – PersonEntity:
          Name:
            NameFull: Zeiser R
      – PersonEntity:
          Name:
            NameFull: Hippen KL
      – PersonEntity:
          Name:
            NameFull: Dustin ML
      – PersonEntity:
          Name:
            NameFull: Blazar BR
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 30
              M: 09
              Text: 2025 Sep 30
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 1558-8238
          Numbering:
            – Type: volume
              Value: 135
            – Type: issue
              Value: 23
          Titles:
            – TitleFull: The Journal of clinical investigation
              Type: main
ResultId 1