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Final Results from a First-in-Human Phase I Study of the Dual Isocitrate Dehydrogenase (IDH) 1/2 Inhibitor, LY3410738, in Advanced Solid Tumors Harboring IDH1 or IDH2 Mutations.

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Title: Final Results from a First-in-Human Phase I Study of the Dual Isocitrate Dehydrogenase (IDH) 1/2 Inhibitor, LY3410738, in Advanced Solid Tumors Harboring IDH1 or IDH2 Mutations.
Authors: Harding JJ; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.; Weill Cornell Medical College, New York, New York., Oh DY; Seoul National University Hospital, Cancer Research Institute, Seoul National University College of Medicine, Integrated Major in Innovative Medical Science, Seoul National University Graduate School, Seoul, South Korea., Mercade TM; Vall d'Hebron University Hospital and Vall d'Hebron Institute of Oncology, Barcelona, Spain., Goyal L; Massachusetts General Hospital Cancer Center, Boston, Massachusetts.; Department of Medicine, Stanford School of Medicine, Palo Alto, California., Varkaris A; Massachusetts General Hospital Cancer Center, Boston, Massachusetts., Palmieri LJ; Department of Medical Oncology, Institut Bergonié, Bordeaux, France., Ikeda M; National Cancer Center Hospital East, Kashiwa, Japan., Kondo S; Department of Experimental Therapeutics, National Cancer Center Hospital, Tokyo, Japan.; Department of Medical Oncology, Tokyo Women's Medical University, Tokyo, Japan., Bai LY; China Medical University Hospital, China Medical University, Taichung, Taiwan., Ueno M; Department of Gastroenterology, Kanagawa Cancer Center, Yokohama, Japan., Chen LT; National Cheng Kung University Hospital, National Cheng Kung University, Tainan, Taiwan.; Kaohsiung Medical University Hospital and Center for Cancer Research, Kaohsiung Medical University, Kaohsiung, Taiwan., Papadopoulos KP; START Center for Cancer Research, San Antonio, Texas., Shroff RT; University of Arizona Cancer Center, Tucson, Arizona., Kizilbash SH; Department of Oncology, Mayo Clinic, Rochester, Minnesota., Hollebecque A; Department of Medical Oncology, Gustave Roussy, Villejuif, France., Adeva J; Department of Medical Oncology, Hospital Universitario 12 de Octubre, Madrid, Spain., Cosman R; The Kinghorn Cancer Centre, St. Vincent's Hospital, Sydney, The University of New South Wales, Sydney, Australia., Yokota T; Department of Head and Neck Medical Oncology, Shizuoka Cancer Center, Sunto-gun, Japan., Park JO; Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea., Turk A; Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, Indiana., Liao CY; Department of Medicine, The University of Chicago Medical Center, Chicago, Illinois., Satoh T; Department of Medical Oncology, Osaka University Hospital, Osaka, Japan., Borad MJ; Department of Oncology, Mayo Clinic Arizona, Scottsdale, Arizona., El-Khoueiry A; Keck School of Medicine, USC Norris Comprehensive Cancer Center, Los Angeles, California., Azad N; Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland., Jaeckle KA; Mayo Clinic Florida, Jacksonville, Florida., Loong HH; Department of Clinical Oncology, The Chinese University of Hong Kong, Shatin, Hong Kong., Yong WP; National University Cancer Institute, Singapore Cancer Science Institute, National University of Singapore, Singapore., Bender MH; Eli Lilly and Company, Indianapolis, Indiana., Varughese SC; Statistics, Eli Lilly Services India Pvt. Ltd., Bengaluru, India., Sachdeva D; Eli Lilly and Company, Indianapolis, Indiana., Radtke DB; Eli Lilly and Company, Indianapolis, Indiana., Gueorguieva I; Eli Lilly and Company, Indianapolis, Indiana., Szpurka AM; Eli Lilly and Company, Indianapolis, Indiana., Chen HR; Eli Lilly and Company, Indianapolis, Indiana., Liu H; Eli Lilly and Company, Indianapolis, Indiana., Xu X; Eli Lilly and Company, Indianapolis, Indiana., Rodon J; MD Anderson Cancer Center, Houston, Texas.
Source: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2025 Dec 01; Vol. 31 (23), pp. 4920-4932.
Publication Type: Journal Article; Clinical Trial, Phase I; Multicenter Study
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9502500 Publication Model: Print Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Final Results from a First-in-Human Phase I Study of the Dual Isocitrate Dehydrogenase (IDH) 1/2 Inhibitor, LY3410738, in Advanced Solid Tumors Harboring IDH1 or IDH2 Mutations.
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Department of Medical Oncology, Institut Bergonié, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Ikeda+M%22">Ikeda M</searchLink>; National Cancer Center Hospital East, Kashiwa, Japan.<br /><searchLink fieldCode="AU" term="%22Kondo+S%22">Kondo S</searchLink>; Department of Experimental Therapeutics, National Cancer Center Hospital, Tokyo, Japan.; Department of Medical Oncology, Tokyo Women's Medical University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Bai+LY%22">Bai LY</searchLink>; China Medical University Hospital, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Ueno+M%22">Ueno M</searchLink>; Department of Gastroenterology, Kanagawa Cancer Center, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Chen+LT%22">Chen LT</searchLink>; National Cheng Kung University Hospital, National Cheng Kung University, Tainan, Taiwan.; Kaohsiung Medical University Hospital and Center for Cancer Research, Kaohsiung Medical University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Papadopoulos+KP%22">Papadopoulos KP</searchLink>; START Center for Cancer Research, San Antonio, Texas.<br /><searchLink fieldCode="AU" term="%22Shroff+RT%22">Shroff RT</searchLink>; University of Arizona Cancer Center, Tucson, Arizona.<br /><searchLink fieldCode="AU" term="%22Kizilbash+SH%22">Kizilbash SH</searchLink>; Department of Oncology, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Hollebecque+A%22">Hollebecque A</searchLink>; Department of Medical Oncology, Gustave Roussy, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Adeva+J%22">Adeva J</searchLink>; Department of Medical Oncology, Hospital Universitario 12 de Octubre, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Cosman+R%22">Cosman R</searchLink>; The Kinghorn Cancer Centre, St. Vincent's Hospital, Sydney, The University of New South Wales, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Yokota+T%22">Yokota T</searchLink>; Department of Head and Neck Medical Oncology, Shizuoka Cancer Center, Sunto-gun, Japan.<br /><searchLink fieldCode="AU" term="%22Park+JO%22">Park JO</searchLink>; Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Turk+A%22">Turk A</searchLink>; Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, Indiana.<br /><searchLink fieldCode="AU" term="%22Liao+CY%22">Liao CY</searchLink>; Department of Medicine, The University of Chicago Medical Center, Chicago, Illinois.<br /><searchLink fieldCode="AU" term="%22Satoh+T%22">Satoh T</searchLink>; Department of Medical Oncology, Osaka University Hospital, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Borad+MJ%22">Borad MJ</searchLink>; Department of Oncology, Mayo Clinic Arizona, Scottsdale, Arizona.<br /><searchLink fieldCode="AU" term="%22El-Khoueiry+A%22">El-Khoueiry A</searchLink>; Keck School of Medicine, USC Norris Comprehensive Cancer Center, Los Angeles, California.<br /><searchLink fieldCode="AU" term="%22Azad+N%22">Azad N</searchLink>; Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Jaeckle+KA%22">Jaeckle KA</searchLink>; Mayo Clinic Florida, Jacksonville, Florida.<br /><searchLink fieldCode="AU" term="%22Loong+HH%22">Loong HH</searchLink>; Department of Clinical Oncology, The Chinese University of Hong Kong, Shatin, Hong Kong.<br /><searchLink fieldCode="AU" term="%22Yong+WP%22">Yong WP</searchLink>; National University Cancer Institute, Singapore Cancer Science Institute, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Bender+MH%22">Bender MH</searchLink>; Eli Lilly and Company, Indianapolis, Indiana.<br /><searchLink fieldCode="AU" term="%22Varughese+SC%22">Varughese SC</searchLink>; Statistics, Eli Lilly Services India Pvt. Ltd., Bengaluru, India.<br /><searchLink fieldCode="AU" term="%22Sachdeva+D%22">Sachdeva D</searchLink>; Eli Lilly and Company, Indianapolis, Indiana.<br /><searchLink fieldCode="AU" term="%22Radtke+DB%22">Radtke DB</searchLink>; Eli Lilly and Company, Indianapolis, Indiana.<br /><searchLink fieldCode="AU" term="%22Gueorguieva+I%22">Gueorguieva I</searchLink>; Eli Lilly and Company, Indianapolis, Indiana.<br /><searchLink fieldCode="AU" term="%22Szpurka+AM%22">Szpurka AM</searchLink>; Eli Lilly and Company, Indianapolis, Indiana.<br /><searchLink fieldCode="AU" term="%22Chen+HR%22">Chen HR</searchLink>; Eli Lilly and Company, Indianapolis, Indiana.<br /><searchLink fieldCode="AU" term="%22Liu+H%22">Liu H</searchLink>; Eli Lilly and Company, Indianapolis, Indiana.<br /><searchLink fieldCode="AU" term="%22Xu+X%22">Xu X</searchLink>; Eli Lilly and Company, Indianapolis, Indiana.<br /><searchLink fieldCode="AU" term="%22Rodon+J%22">Rodon J</searchLink>; MD Anderson Cancer Center, Houston, Texas.
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