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Aberrant intermediate alveolar epithelial cells promote pathogenic activation of lung fibroblasts in preclinical fibrosis models.

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Title: Aberrant intermediate alveolar epithelial cells promote pathogenic activation of lung fibroblasts in preclinical fibrosis models.
Authors: Hoffman ET; Pulmonary, Allergy, and Critical Care Medicine Division, University of Pennsylvania, Philadelphia, PA, USA., Shah A; Pulmonary, Allergy, and Critical Care Medicine Division, University of Pennsylvania, Philadelphia, PA, USA., Barboza WR; Pulmonary, Allergy, and Critical Care Medicine Division, University of Pennsylvania, Philadelphia, PA, USA., Rodriguez LR; Pulmonary, Allergy, and Critical Care Medicine Division, University of Pennsylvania, Philadelphia, PA, USA., Dherwani R; Pulmonary, Allergy, and Critical Care Medicine Division, University of Pennsylvania, Philadelphia, PA, USA., Dooley PE; Center for Regenerative Medicine, Boston University and Boston Medical Center, Boston, MA, USA.; The Pulmonary Center and Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA., Minakin K; Center for Regenerative Medicine, Boston University and Boston Medical Center, Boston, MA, USA.; The Pulmonary Center and Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA., Tomer Y; Pulmonary, Allergy, and Critical Care Medicine Division, University of Pennsylvania, Philadelphia, PA, USA., Ayers LJ; Center for Regenerative Medicine, Boston University and Boston Medical Center, Boston, MA, USA.; The Pulmonary Center and Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA., Jones D; Center for Regenerative Medicine, Boston University and Boston Medical Center, Boston, MA, USA.; The Pulmonary Center and Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA., Murthy A; Pulmonary, Allergy, and Critical Care Medicine Division, University of Pennsylvania, Philadelphia, PA, USA., Bennett A; Pulmonary, Allergy, and Critical Care Medicine Division, University of Pennsylvania, Philadelphia, PA, USA., Lange AN; Center for Regenerative Medicine, Boston University and Boston Medical Center, Boston, MA, USA., Bawa PS; Center for Regenerative Medicine, Boston University and Boston Medical Center, Boston, MA, USA., Wang F; Center for Regenerative Medicine, Boston University and Boston Medical Center, Boston, MA, USA., Babu A; PENN -CHOP Lung Biology Institute, University of Pennsylvania, Philadelphia, PA, USA., Chavez K; Pulmonary, Allergy, and Critical Care Medicine Division, University of Pennsylvania, Philadelphia, PA, USA., Nakamoto RS; Pulmonary, Allergy, and Critical Care Medicine Division, University of Pennsylvania, Philadelphia, PA, USA., Cooper CH; Pulmonary, Allergy, and Critical Care Medicine Division, University of Pennsylvania, Philadelphia, PA, USA., Basil MC; Pulmonary, Allergy, and Critical Care Medicine Division, University of Pennsylvania, Philadelphia, PA, USA.; PENN -CHOP Lung Biology Institute, University of Pennsylvania, Philadelphia, PA, USA., Raredon MSB; Department of Anesthesiology, Yale School of Medicine, New Haven, CT, USA.; Vascular Biology and Therapeutics Program, Yale School of Medicine, New Haven, CT, USA.; Program in Translational Biomedicine (PTB), Yale School of Medicine, New Haven, CT, USA., Kotton DN; Center for Regenerative Medicine, Boston University and Boston Medical Center, Boston, MA, USA.; The Pulmonary Center and Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA., Alysandratos KD; Center for Regenerative Medicine, Boston University and Boston Medical Center, Boston, MA, USA.; The Pulmonary Center and Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA., Katzen J; Pulmonary, Allergy, and Critical Care Medicine Division, University of Pennsylvania, Philadelphia, PA, USA. Jeremy.Katzen@pennmedicine.upenn.edu.; PENN -CHOP Lung Biology Institute, University of Pennsylvania, Philadelphia, PA, USA. Jeremy.Katzen@pennmedicine.upenn.edu.
Source: Nature communications [Nat Commun] 2025 Sep 30; Vol. 16 (1), pp. 8710. Date of Electronic Publication: 2025 Sep 30.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Aberrant intermediate alveolar epithelial cells promote pathogenic activation of lung fibroblasts in preclinical fibrosis models.
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Center for Regenerative Medicine, Boston University and Boston Medical Center, Boston, MA, USA.; The Pulmonary Center and Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Minakin+K%22">Minakin K</searchLink>; Center for Regenerative Medicine, Boston University and Boston Medical Center, Boston, MA, USA.; The Pulmonary Center and Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Tomer+Y%22">Tomer Y</searchLink>; Pulmonary, Allergy, and Critical Care Medicine Division, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Ayers+LJ%22">Ayers LJ</searchLink>; Center for Regenerative Medicine, Boston University and Boston Medical Center, Boston, MA, USA.; The Pulmonary Center and Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Jones+D%22">Jones D</searchLink>; 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Pulmonary, Allergy, and Critical Care Medicine Division, University of Pennsylvania, Philadelphia, PA, USA. Jeremy.Katzen@pennmedicine.upenn.edu.; PENN -CHOP Lung Biology Institute, University of Pennsylvania, Philadelphia, PA, USA. Jeremy.Katzen@pennmedicine.upenn.edu.
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