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Distal mutations enhance catalysis in designed enzymes by facilitating substrate binding and product release.

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Title: Distal mutations enhance catalysis in designed enzymes by facilitating substrate binding and product release.
Authors: Zarifi N; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Ontario, Canada.; Center for Catalysis Research and Innovation, University of Ottawa, Ottawa, Ontario, Canada., Asthana P; Department of Bioengineering and Therapeutic Science, University of California, San Francisco, San Francisco, CA, USA., Doustmohammadi H; Institut de Química Computacional i Catàlisi and Departament de Química, Universitat de Girona, Girona, Spain., Klaus C; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Ontario, Canada.; Center for Catalysis Research and Innovation, University of Ottawa, Ottawa, Ontario, Canada., Sanchez J; Institut de Química Computacional i Catàlisi and Departament de Química, Universitat de Girona, Girona, Spain., Hunt SE; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Ontario, Canada.; Center for Catalysis Research and Innovation, University of Ottawa, Ottawa, Ontario, Canada., Rakotoharisoa RV; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Ontario, Canada.; Center for Catalysis Research and Innovation, University of Ottawa, Ottawa, Ontario, Canada., Osuna S; Institut de Química Computacional i Catàlisi and Departament de Química, Universitat de Girona, Girona, Spain.; ICREA, Barcelona, Spain., Fraser JS; Department of Bioengineering and Therapeutic Science, University of California, San Francisco, San Francisco, CA, USA., Chica RA; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Ontario, Canada. rchica@uottawa.ca.; Center for Catalysis Research and Innovation, University of Ottawa, Ottawa, Ontario, Canada. rchica@uottawa.ca.
Source: Nature communications [Nat Commun] 2025 Sep 30; Vol. 16 (1), pp. 8662. Date of Electronic Publication: 2025 Sep 30.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Distal mutations enhance catalysis in designed enzymes by facilitating substrate binding and product release.
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  Data: <searchLink fieldCode="AU" term="%22Zarifi+N%22">Zarifi N</searchLink>; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Ontario, Canada.; Center for Catalysis Research and Innovation, University of Ottawa, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Asthana+P%22">Asthana P</searchLink>; Department of Bioengineering and Therapeutic Science, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Doustmohammadi+H%22">Doustmohammadi H</searchLink>; Institut de Química Computacional i Catàlisi and Departament de Química, Universitat de Girona, Girona, Spain.<br /><searchLink fieldCode="AU" term="%22Klaus+C%22">Klaus C</searchLink>; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Ontario, Canada.; Center for Catalysis Research and Innovation, University of Ottawa, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Sanchez+J%22">Sanchez J</searchLink>; Institut de Química Computacional i Catàlisi and Departament de Química, Universitat de Girona, Girona, Spain.<br /><searchLink fieldCode="AU" term="%22Hunt+SE%22">Hunt SE</searchLink>; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Ontario, Canada.; Center for Catalysis Research and Innovation, University of Ottawa, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Rakotoharisoa+RV%22">Rakotoharisoa RV</searchLink>; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Ontario, Canada.; Center for Catalysis Research and Innovation, University of Ottawa, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Osuna+S%22">Osuna S</searchLink>; Institut de Química Computacional i Catàlisi and Departament de Química, Universitat de Girona, Girona, Spain.; ICREA, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Fraser+JS%22">Fraser JS</searchLink>; Department of Bioengineering and Therapeutic Science, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chica+RA%22">Chica RA</searchLink>; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Ontario, Canada. rchica@uottawa.ca.; Center for Catalysis Research and Innovation, University of Ottawa, Ottawa, Ontario, Canada. rchica@uottawa.ca.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 Sep 30; Vol. 16 (1), pp. 8662. <i>Date of Electronic Publication: </i>2025 Sep 30.
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              Text: 2025 Sep 30
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