Distal mutations enhance catalysis in designed enzymes by facilitating substrate binding and product release.
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| Title: | Distal mutations enhance catalysis in designed enzymes by facilitating substrate binding and product release. |
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| Authors: | Zarifi N; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Ontario, Canada.; Center for Catalysis Research and Innovation, University of Ottawa, Ottawa, Ontario, Canada., Asthana P; Department of Bioengineering and Therapeutic Science, University of California, San Francisco, San Francisco, CA, USA., Doustmohammadi H; Institut de Química Computacional i Catàlisi and Departament de Química, Universitat de Girona, Girona, Spain., Klaus C; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Ontario, Canada.; Center for Catalysis Research and Innovation, University of Ottawa, Ottawa, Ontario, Canada., Sanchez J; Institut de Química Computacional i Catàlisi and Departament de Química, Universitat de Girona, Girona, Spain., Hunt SE; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Ontario, Canada.; Center for Catalysis Research and Innovation, University of Ottawa, Ottawa, Ontario, Canada., Rakotoharisoa RV; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Ontario, Canada.; Center for Catalysis Research and Innovation, University of Ottawa, Ottawa, Ontario, Canada., Osuna S; Institut de Química Computacional i Catàlisi and Departament de Química, Universitat de Girona, Girona, Spain.; ICREA, Barcelona, Spain., Fraser JS; Department of Bioengineering and Therapeutic Science, University of California, San Francisco, San Francisco, CA, USA., Chica RA; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Ontario, Canada. rchica@uottawa.ca.; Center for Catalysis Research and Innovation, University of Ottawa, Ottawa, Ontario, Canada. rchica@uottawa.ca. |
| Source: | Nature communications [Nat Commun] 2025 Sep 30; Vol. 16 (1), pp. 8662. Date of Electronic Publication: 2025 Sep 30. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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