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SGLT2 inhibition protects kidney function by SAM-dependent epigenetic repression of inflammatory genes under metabolic stress.

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Title: SGLT2 inhibition protects kidney function by SAM-dependent epigenetic repression of inflammatory genes under metabolic stress.
Authors: Maekawa H; Feinberg Cardiovascular & Renal Research Institute.; Division of Nephrology & Hypertension, Department of Medicine., Zhou Y; Feinberg Cardiovascular & Renal Research Institute.; Division of Nephrology & Hypertension, Department of Medicine., Aoi Y; Department of Biochemistry and Molecular Genetics, and.; Simpson Querrey Institute for Epigenetics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Fain ME; Feinberg Cardiovascular & Renal Research Institute.; Division of Nephrology & Hypertension, Department of Medicine., Kaminski DS; Feinberg Cardiovascular & Renal Research Institute.; Division of Nephrology & Hypertension, Department of Medicine., Kong H; Department of Medicine & Biochemistry and Molecular Genetics, Northwestern University, Chicago, Illinois, USA., Sebo ZL; Department of Medicine & Biochemistry and Molecular Genetics, Northwestern University, Chicago, Illinois, USA., Chakrabarty RP; Department of Medicine & Biochemistry and Molecular Genetics, Northwestern University, Chicago, Illinois, USA., Howard BC; Department of Biochemistry and Molecular Genetics, and.; Simpson Querrey Institute for Epigenetics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Andersen G; Department of Biochemistry and Molecular Genetics, and.; Simpson Querrey Institute for Epigenetics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Marcheva B; Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, and., Gao P; Robert H. Lurie Cancer Center Metabolomics Core, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Kapitsinou P; Feinberg Cardiovascular & Renal Research Institute.; Division of Nephrology & Hypertension, Department of Medicine., Bass J; Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, and., Shilatifard A; Department of Biochemistry and Molecular Genetics, and.; Simpson Querrey Institute for Epigenetics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Chandel NS; Department of Medicine & Biochemistry and Molecular Genetics, Northwestern University, Chicago, Illinois, USA., Quaggin SE; Feinberg Cardiovascular & Renal Research Institute.; Division of Nephrology & Hypertension, Department of Medicine.
Source: The Journal of clinical investigation [J Clin Invest] 2025 Oct 01; Vol. 135 (19). Date of Electronic Publication: 2025 Oct 01 (Print Publication: 2025).
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: eCollection Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: SGLT2 inhibition protects kidney function by SAM-dependent epigenetic repression of inflammatory genes under metabolic stress.
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  Data: <searchLink fieldCode="AU" term="%22Maekawa+H%22">Maekawa H</searchLink>; Feinberg Cardiovascular & Renal Research Institute.; Division of Nephrology & Hypertension, Department of Medicine.<br /><searchLink fieldCode="AU" term="%22Zhou+Y%22">Zhou Y</searchLink>; Feinberg Cardiovascular & Renal Research Institute.; Division of Nephrology & Hypertension, Department of Medicine.<br /><searchLink fieldCode="AU" term="%22Aoi+Y%22">Aoi Y</searchLink>; Department of Biochemistry and Molecular Genetics, and.; Simpson Querrey Institute for Epigenetics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Fain+ME%22">Fain ME</searchLink>; Feinberg Cardiovascular & Renal Research Institute.; Division of Nephrology & Hypertension, Department of Medicine.<br /><searchLink fieldCode="AU" term="%22Kaminski+DS%22">Kaminski DS</searchLink>; Feinberg Cardiovascular & Renal Research Institute.; Division of Nephrology & Hypertension, Department of Medicine.<br /><searchLink fieldCode="AU" term="%22Kong+H%22">Kong H</searchLink>; Department of Medicine & Biochemistry and Molecular Genetics, Northwestern University, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Sebo+ZL%22">Sebo ZL</searchLink>; Department of Medicine & Biochemistry and Molecular Genetics, Northwestern University, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Chakrabarty+RP%22">Chakrabarty RP</searchLink>; Department of Medicine & Biochemistry and Molecular Genetics, Northwestern University, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Howard+BC%22">Howard BC</searchLink>; Department of Biochemistry and Molecular Genetics, and.; Simpson Querrey Institute for Epigenetics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Andersen+G%22">Andersen G</searchLink>; Department of Biochemistry and Molecular Genetics, and.; Simpson Querrey Institute for Epigenetics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Marcheva+B%22">Marcheva B</searchLink>; Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, and.<br /><searchLink fieldCode="AU" term="%22Gao+P%22">Gao P</searchLink>; Robert H. Lurie Cancer Center Metabolomics Core, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Kapitsinou+P%22">Kapitsinou P</searchLink>; Feinberg Cardiovascular & Renal Research Institute.; Division of Nephrology & Hypertension, Department of Medicine.<br /><searchLink fieldCode="AU" term="%22Bass+J%22">Bass J</searchLink>; Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, and.<br /><searchLink fieldCode="AU" term="%22Shilatifard+A%22">Shilatifard A</searchLink>; Department of Biochemistry and Molecular Genetics, and.; Simpson Querrey Institute for Epigenetics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Chandel+NS%22">Chandel NS</searchLink>; Department of Medicine & Biochemistry and Molecular Genetics, Northwestern University, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Quaggin+SE%22">Quaggin SE</searchLink>; Feinberg Cardiovascular & Renal Research Institute.; Division of Nephrology & Hypertension, Department of Medicine.
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  Data: <searchLink fieldCode="JN" term="%227802877%22">The Journal of clinical investigation</searchLink> [J Clin Invest] 2025 Oct 01; Vol. 135 (19). <i>Date of Electronic Publication: </i>2025 Oct 01 (<i>Print Publication: </i>2025).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Society+for+Clinical+Investigation%22">American Society for Clinical Investigation </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7802877 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1558-8238 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200219738%22">00219738 </searchLink><i>NLM ISO Abbreviation: </i>J Clin Invest <i>Subsets: </i>MEDLINE
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