SGLT2 inhibition protects kidney function by SAM-dependent epigenetic repression of inflammatory genes under metabolic stress.
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| Title: | SGLT2 inhibition protects kidney function by SAM-dependent epigenetic repression of inflammatory genes under metabolic stress. |
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| Authors: | Maekawa H; Feinberg Cardiovascular & Renal Research Institute.; Division of Nephrology & Hypertension, Department of Medicine., Zhou Y; Feinberg Cardiovascular & Renal Research Institute.; Division of Nephrology & Hypertension, Department of Medicine., Aoi Y; Department of Biochemistry and Molecular Genetics, and.; Simpson Querrey Institute for Epigenetics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Fain ME; Feinberg Cardiovascular & Renal Research Institute.; Division of Nephrology & Hypertension, Department of Medicine., Kaminski DS; Feinberg Cardiovascular & Renal Research Institute.; Division of Nephrology & Hypertension, Department of Medicine., Kong H; Department of Medicine & Biochemistry and Molecular Genetics, Northwestern University, Chicago, Illinois, USA., Sebo ZL; Department of Medicine & Biochemistry and Molecular Genetics, Northwestern University, Chicago, Illinois, USA., Chakrabarty RP; Department of Medicine & Biochemistry and Molecular Genetics, Northwestern University, Chicago, Illinois, USA., Howard BC; Department of Biochemistry and Molecular Genetics, and.; Simpson Querrey Institute for Epigenetics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Andersen G; Department of Biochemistry and Molecular Genetics, and.; Simpson Querrey Institute for Epigenetics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Marcheva B; Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, and., Gao P; Robert H. Lurie Cancer Center Metabolomics Core, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Kapitsinou P; Feinberg Cardiovascular & Renal Research Institute.; Division of Nephrology & Hypertension, Department of Medicine., Bass J; Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, and., Shilatifard A; Department of Biochemistry and Molecular Genetics, and.; Simpson Querrey Institute for Epigenetics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Chandel NS; Department of Medicine & Biochemistry and Molecular Genetics, Northwestern University, Chicago, Illinois, USA., Quaggin SE; Feinberg Cardiovascular & Renal Research Institute.; Division of Nephrology & Hypertension, Department of Medicine. |
| Source: | The Journal of clinical investigation [J Clin Invest] 2025 Oct 01; Vol. 135 (19). Date of Electronic Publication: 2025 Oct 01 (Print Publication: 2025). |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: eCollection Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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