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Discovery of Lenacapavir: First-in-Class Twice-Yearly Capsid Inhibitor for HIV-1 Treatment and Pre-exposure Prophylaxis.

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Title: Discovery of Lenacapavir: First-in-Class Twice-Yearly Capsid Inhibitor for HIV-1 Treatment and Pre-exposure Prophylaxis.
Authors: Canales E; Medicinal Chemistry, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California 94404, United States., Tse W; Medicinal Chemistry, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California 94404, United States., Schroeder SD; Medicinal Chemistry, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California 94404, United States., Chou CH; Medicinal Chemistry, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California 94404, United States., Liu Q; Medicinal Chemistry, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California 94404, United States., Zhang J; Medicinal Chemistry, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California 94404, United States., Lazerwith SE; Medicinal Chemistry, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California 94404, United States., Morganelli P; Medicinal Chemistry, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California 94404, United States., Saito RD; Medicinal Chemistry, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California 94404, United States., Brizgys G; Medicinal Chemistry, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California 94404, United States., Li J; Medicinal Chemistry, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California 94404, United States., Wu Q; Medicinal Chemistry, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California 94404, United States., Graupe M; Medicinal Chemistry, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California 94404, United States., Halcomb RL; Medicinal Chemistry, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California 94404, United States., Desai M; Medicinal Chemistry, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California 94404, United States., Cannizzaro C; Structural Biology and Chemistry, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California 94404, United States., Hu E; Structural Biology and Chemistry, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California 94404, United States., Perry JK; Structural Biology and Chemistry, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California 94404, United States., Villaseñor AG; Structural Biology and Chemistry, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California 94404, United States., Somoza JR; Structural Biology and Chemistry, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California 94404, United States., Ferrao RD; Structural Biology and Chemistry, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California 94404, United States., Swaminathan S; Structural Biology and Chemistry, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California 94404, United States., Zheng J; Drug Metabolism, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California 94404, United States., Lu B; Drug Metabolism, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California 94404, United States., Mwangi J; Drug Metabolism, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California 94404, United States., Wang K; Drug Metabolism, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California 94404, United States., Subramanian R; Drug Metabolism, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California 94404, United States., Smith BJ; Drug Metabolism, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California 94404, United States., Rhodes G; Drug Metabolism, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California 94404, United States., Rowe W; Formulation and Process Development, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California 94404, United States., Sauer D; Formulation and Process Development, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California 94404, United States., Lad L; Research Discovery Sciences and Technologies, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California 94404, United States., Papalia GA; Research Discovery Sciences and Technologies, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California 94404, United States., Clancy S; Research Discovery Sciences and Technologies, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California 94404, United States., Stepan GJ; Research Discovery Sciences and Technologies, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California 94404, United States., Yu H; Research Discovery Sciences and Technologies, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California 94404, United States., Sakowicz R; Research Discovery Sciences and Technologies, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California 94404, United States., Shi B; Process Development, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California 94404, United States., Carr G; Process Development, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California 94404, United States., Bam RA; Discovery Virology, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California 94404, United States., Tsai LK; Discovery Virology, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California 94404, United States., Singer E; Discovery Virology, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California 94404, United States., Hansen D; Discovery Virology, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California 94404, United States., Mulato A; Discovery Virology, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California 94404, United States., Yant SR; Discovery Virology, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California 94404, United States., Cihlar T; Discovery Virology, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California 94404, United States., Link JO; Medicinal Chemistry, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, California 94404, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2025 Oct 23; Vol. 68 (20), pp. 21072-21094. Date of Electronic Publication: 2025 Oct 01.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
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