Fibrinolytic Therapy for Thromboembolic Diseases: Approved Indications and Future Directions.

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Title: Fibrinolytic Therapy for Thromboembolic Diseases: Approved Indications and Future Directions.
Authors: Rashedi S; Thrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Leyva H; Thrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Hamade N; Thrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Pfeferman MB; Thrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Ortega-Paz L; Division of Cardiology, University of Florida College of Medicine, Jacksonville, Florida, USA., Sadeghipour P; Vascular Disease and Thrombosis Research Center, Rajaie Cardiovascular Institute, Tehran, Iran; Clinical Trial Center, Rajaie Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, Iran., Talasaz AH; Department of Pharmacotherapy & Outcomes Sciences, Virginia Commonwealth University, Richmond, Virginia, USA; Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Department of Pharmacy Practice, Long Island University, New York, New York, USA; Department of Pharmacy, New York-Presbyterian Hospital, Columbia University Medical Center, New York, New York, USA., O'Donoghue ML; TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Jimenez D; Respiratory Department, Hospital Ramón y Cajal (IRYCIS), Madrid, Spain; Medicine Department, Universidad de Alcalá (IRYCIS), Madrid, Spain; CIBER Enfermedades Respiratorias (CIBERES), Madrid, Spain., Monreal M; Thromboembolic Disorders, Facultad de Medicina, Universidad Catolica San Antonio de Murcia, Murcia, Spain., Anderson CD; Program in Medical and Population Genetics, Broad Institute of Harvard and the Massachusetts Institute of Technology, Boston, Massachusetts, USA; McCance Center for Brain Health, Mass General Brigham, Boston, Massachusetts, USA; Department of Neurology, Mass General Brigham, Boston, Massachusetts, USA., Elkind MSV; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA., Lang IM; Department of Internal Medicine II, Cardiology and Center of Cardiovascular Medicine, Medical University of Vienna, Vienna, Austria., Weitz JI; Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada; Department of Medicine and Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Goldhaber SZ; Thrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., De Caterina R; University Cardiology Division, Pisa University Hospital, Pisa, Italy; Postgraduate School of Cardiology, University of Pisa, Pisa, Italy; Fondazione Villa Serena per la Ricerca, Città Sant'Angelo, Pescara, Italy., Konstantinides SV; Center for Thrombosis and Haemostasis, University Medical Center of the Johannes Gutenberg University, Mainz, Germany; Department of Cardiology, Democritus University of Thrace, Alexandroupolis, Greece., Piazza G; Thrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Krumholz HM; YNHH/ Yale Center for Outcomes Research and Evaluation (CORE), New Haven, Connecticut, USA; Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, Connecticut, USA; Department of Health Policy and Management, Yale School of Public Health, New Haven, Connecticut, USA., Braunwald E; TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Bikdeli B; Thrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; YNHH/ Yale Center for Outcomes Research and Evaluation (CORE), New Haven, Connecticut, USA. Electronic address: bbikdeli@bwh.harvard.edu.
Source: Journal of the American College of Cardiology [J Am Coll Cardiol] 2025 Oct 07; Vol. 86 (14), pp. 1065-1087.
Publication Type: Journal Article; Review
Journal Info: Publisher: Elsevier Biomedical Country of Publication: United States NLM ID: 8301365 Publication Model: Print Cited Medium: Internet ISSN: 1558-3597 (Electronic) Linking ISSN: 07351097 NLM ISO Abbreviation: J Am Coll Cardiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Fibrinolytic Therapy for Thromboembolic Diseases: Approved Indications and Future Directions.
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  Data: <searchLink fieldCode="AU" term="%22Rashedi+S%22">Rashedi S</searchLink>; Thrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Leyva+H%22">Leyva H</searchLink>; Thrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Hamade+N%22">Hamade N</searchLink>; Thrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Pfeferman+MB%22">Pfeferman MB</searchLink>; Thrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Ortega-Paz+L%22">Ortega-Paz L</searchLink>; Division of Cardiology, University of Florida College of Medicine, Jacksonville, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Sadeghipour+P%22">Sadeghipour P</searchLink>; Vascular Disease and Thrombosis Research Center, Rajaie Cardiovascular Institute, Tehran, Iran; Clinical Trial Center, Rajaie Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Talasaz+AH%22">Talasaz AH</searchLink>; Department of Pharmacotherapy & Outcomes Sciences, Virginia Commonwealth University, Richmond, Virginia, USA; Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Department of Pharmacy Practice, Long Island University, New York, New York, USA; Department of Pharmacy, New York-Presbyterian Hospital, Columbia University Medical Center, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22O'Donoghue+ML%22">O'Donoghue ML</searchLink>; TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Jimenez+D%22">Jimenez D</searchLink>; Respiratory Department, Hospital Ramón y Cajal (IRYCIS), Madrid, Spain; Medicine Department, Universidad de Alcalá (IRYCIS), Madrid, Spain; CIBER Enfermedades Respiratorias (CIBERES), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Monreal+M%22">Monreal M</searchLink>; Thromboembolic Disorders, Facultad de Medicina, Universidad Catolica San Antonio de Murcia, Murcia, Spain.<br /><searchLink fieldCode="AU" term="%22Anderson+CD%22">Anderson CD</searchLink>; Program in Medical and Population Genetics, Broad Institute of Harvard and the Massachusetts Institute of Technology, Boston, Massachusetts, USA; McCance Center for Brain Health, Mass General Brigham, Boston, Massachusetts, USA; Department of Neurology, Mass General Brigham, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Elkind+MSV%22">Elkind MSV</searchLink>; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Lang+IM%22">Lang IM</searchLink>; Department of Internal Medicine II, Cardiology and Center of Cardiovascular Medicine, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Weitz+JI%22">Weitz JI</searchLink>; Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada; Department of Medicine and Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Goldhaber+SZ%22">Goldhaber SZ</searchLink>; Thrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22De+Caterina+R%22">De Caterina R</searchLink>; University Cardiology Division, Pisa University Hospital, Pisa, Italy; Postgraduate School of Cardiology, University of Pisa, Pisa, Italy; Fondazione Villa Serena per la Ricerca, Città Sant'Angelo, Pescara, Italy.<br /><searchLink fieldCode="AU" term="%22Konstantinides+SV%22">Konstantinides SV</searchLink>; Center for Thrombosis and Haemostasis, University Medical Center of the Johannes Gutenberg University, Mainz, Germany; Department of Cardiology, Democritus University of Thrace, Alexandroupolis, Greece.<br /><searchLink fieldCode="AU" term="%22Piazza+G%22">Piazza G</searchLink>; Thrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Krumholz+HM%22">Krumholz HM</searchLink>; YNHH/ Yale Center for Outcomes Research and Evaluation (CORE), New Haven, Connecticut, USA; Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, Connecticut, USA; Department of Health Policy and Management, Yale School of Public Health, New Haven, Connecticut, USA.<br /><searchLink fieldCode="AU" term="%22Braunwald+E%22">Braunwald E</searchLink>; TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Bikdeli+B%22">Bikdeli B</searchLink>; Thrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; YNHH/ Yale Center for Outcomes Research and Evaluation (CORE), New Haven, Connecticut, USA. Electronic address: bbikdeli@bwh.harvard.edu.
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