Self-cleavage of the GAIN domain of adhesion G protein-coupled receptors requires multiple domain-extrinsic factors.
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| Title: | Self-cleavage of the GAIN domain of adhesion G protein-coupled receptors requires multiple domain-extrinsic factors. |
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| Authors: | Chung YK; Rudolf Schönheimer Institute of Biochemistry, Division of General Biochemistry, Medical Faculty, Leipzig University, Leipzig, Germany.; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Ihling CH; Department of Pharmaceutical Chemistry and Bioanalytics, Martin-Luther-University Halle-Wittenberg, Halle, Germany.; Center for Structural Mass Spectrometry, Martin-Luther-University Halle-Wittenberg, Halle, Germany., Zielke L; Rudolf Schönheimer Institute of Biochemistry, Division of General Biochemistry, Medical Faculty, Leipzig University, Leipzig, Germany., Mathiasen S; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Sinz A; Department of Pharmaceutical Chemistry and Bioanalytics, Martin-Luther-University Halle-Wittenberg, Halle, Germany.; Center for Structural Mass Spectrometry, Martin-Luther-University Halle-Wittenberg, Halle, Germany., Langenhan T; Rudolf Schönheimer Institute of Biochemistry, Division of General Biochemistry, Medical Faculty, Leipzig University, Leipzig, Germany. tobias.langenhan@gmail.com.; Comprehensive Cancer Center Central Germany, Leipzig University, Leipzig, Germany. tobias.langenhan@gmail.com.; Institute of Biology, Faculty of Life Sciences, Leipzig University, Leipzig, Germany. tobias.langenhan@gmail.com. |
| Source: | Nature communications [Nat Commun] 2025 Oct 01; Vol. 16 (1), pp. 8736. Date of Electronic Publication: 2025 Oct 01. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-64589-3 |
