The Panoptes system uses decoy cyclic nucleotides to defend against phage.

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Title: The Panoptes system uses decoy cyclic nucleotides to defend against phage.
Authors: Sullivan AE; Department of Biochemistry, University of Colorado Boulder, Boulder, CO, USA., Nabhani A; Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, USA., Izrailevsky DS; Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, USA., Schinkel K; Department of Biochemistry, University of Colorado Boulder, Boulder, CO, USA., Hoffman CRK; Department of Biochemistry, University of Colorado Boulder, Boulder, CO, USA., Robbins LK; Department of Biochemistry, University of Colorado Boulder, Boulder, CO, USA., Nagy TA; Department of Biochemistry, University of Colorado Boulder, Boulder, CO, USA., Duncan ML; Department of Biochemistry, University of Colorado Boulder, Boulder, CO, USA., Ledvina HE; Department of Biochemistry, University of Colorado Boulder, Boulder, CO, USA., Erbse AH; Department of Biochemistry, University of Colorado Boulder, Boulder, CO, USA., Kibby EM; Department of Biochemistry, University of Colorado Boulder, Boulder, CO, USA., Tak U; Department of Biochemistry, University of Colorado Boulder, Boulder, CO, USA., Dinh DM; Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, USA., Ednacot EMQ; Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, USA.; Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, CA, USA., Nguyen CM; Department of Biological Chemistry, University of California, Irvine, Irvine, CA, USA.; Center for Epigenetics and Metabolism, University of California, Irvine, Irvine, CA, USA., Burroughs AM; Computational Biology Branch, Division of Intramural Research, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA., Aravind L; Computational Biology Branch, Division of Intramural Research, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA., Whiteley AT; Department of Biochemistry, University of Colorado Boulder, Boulder, CO, USA. aaron.whiteley@colorado.edu., Morehouse BR; Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, USA. b.morehouse@uci.edu.; Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, CA, USA. b.morehouse@uci.edu.; Institute for Immunology, University of California, Irvine, Irvine, CA, USA. b.morehouse@uci.edu.; Center for Virus Research, University of California, Irvine, Irvine, CA, USA. b.morehouse@uci.edu.
Source: Nature [Nature] 2025 Nov; Vol. 647 (8091), pp. 988-996. Date of Electronic Publication: 2025 Oct 01.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-4687
DOI:10.1038/s41586-025-09557-z