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Polygenic and developmental profiles of autism differ by age at diagnosis.

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Title: Polygenic and developmental profiles of autism differ by age at diagnosis.
Authors: Zhang X; Department of Psychiatry, University of Cambridge, Cambridge, UK. xz452@cam.ac.uk.; Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK. xz452@cam.ac.uk., Grove J; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Center for Genomics and Personalized Medicine (CGPM), Aarhus University, Aarhus, Denmark.; Department of Biomedicine (Human Genetics), Aarhus University, Aarhus, Denmark.; Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark.; Centre for Integrative Sequencing (iSEQ), Aarhus University, Aarhus, Denmark., Gu Y; Department of Psychiatry, University of Cambridge, Cambridge, UK.; Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK., Buus CK; Department of Biomedicine (Human Genetics), Aarhus University, Aarhus, Denmark.; Centre for Integrative Sequencing (iSEQ), Aarhus University, Aarhus, Denmark., Nielsen LK; Department of Biomedicine (Human Genetics), Aarhus University, Aarhus, Denmark.; Centre for Integrative Sequencing (iSEQ), Aarhus University, Aarhus, Denmark., Neufeld SAS; Department of Psychiatry, University of Cambridge, Cambridge, UK., Koko M; Human Genetics Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Malawsky DS; Human Genetics Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Wade EM; Human Genetics Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Verhoef E; Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands., Gui A; Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.; Centre for Brain and Cognitive Development, Department of Psychological Sciences, Birkbeck University of London, London, UK., Hegemann L; Research Department, Lovisenberg Diaconal Hospital, Oslo, Norway.; PsychGen Centre for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway., Geschwind DH; Program in Neurobehavioral Genetics and Center for Autism Research and Treatment, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.; Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Psychiatry, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Wray NR; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.; Department of Psychiatry, University of Oxford, Oxford, UK., Havdahl A; Research Department, Lovisenberg Diaconal Hospital, Oslo, Norway.; PsychGen Centre for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway.; Promenta Research Centre, Department of Psychology, University of Oslo, Oslo, Norway., Ronald A; Centre for Brain and Cognitive Development, Department of Psychological Sciences, Birkbeck University of London, London, UK.; School of Psychology, University of Surrey, Guildford, UK., St Pourcain B; Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands.; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands., Robinson EB; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Bourgeron T; Human Genetics and Cognitive Functions, Institut Pasteur, UMR3571 CNRS, IUF, Université Paris Cité, Paris, France., Baron-Cohen S; Department of Psychiatry, University of Cambridge, Cambridge, UK.; Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK.; Department of Psychology, University of Cambridge, Cambridge, UK., Børglum AD; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Center for Genomics and Personalized Medicine (CGPM), Aarhus University, Aarhus, Denmark.; Department of Biomedicine (Human Genetics), Aarhus University, Aarhus, Denmark.; Centre for Integrative Sequencing (iSEQ), Aarhus University, Aarhus, Denmark., Martin HC; Human Genetics Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.; Wellcome Trust Sanger Institute, Hinxton, UK., Warrier V; Department of Psychiatry, University of Cambridge, Cambridge, UK. vw260@cam.ac.uk.; Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK. vw260@cam.ac.uk.; Department of Psychology, University of Cambridge, Cambridge, UK. vw260@cam.ac.uk.
Corporate Authors: APEX Consortium, iPSYCH Autism Consortium, PGC-PTSD Consortium
Source: Nature [Nature] 2025 Oct; Vol. 646 (8087), pp. 1146-1155. Date of Electronic Publication: 2025 Oct 01.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Polygenic and developmental profiles of autism differ by age at diagnosis.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Department of Psychiatry, University of Cambridge, Cambridge, UK. xz452@cam.ac.uk.; Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK. xz452@cam.ac.uk.<br /><searchLink fieldCode="AU" term="%22Grove+J%22">Grove J</searchLink>; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Center for Genomics and Personalized Medicine (CGPM), Aarhus University, Aarhus, Denmark.; Department of Biomedicine (Human Genetics), Aarhus University, Aarhus, Denmark.; Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark.; Centre for Integrative Sequencing (iSEQ), Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Gu+Y%22">Gu Y</searchLink>; Department of Psychiatry, University of Cambridge, Cambridge, UK.; Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Buus+CK%22">Buus CK</searchLink>; 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Department of Psychology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Børglum+AD%22">Børglum AD</searchLink>; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Center for Genomics and Personalized Medicine (CGPM), Aarhus University, Aarhus, Denmark.; Department of Biomedicine (Human Genetics), Aarhus University, Aarhus, Denmark.; Centre for Integrative Sequencing (iSEQ), Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Martin+HC%22">Martin HC</searchLink>; Human Genetics Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.; Wellcome Trust Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Warrier+V%22">Warrier V</searchLink>; Department of Psychiatry, University of Cambridge, Cambridge, UK. vw260@cam.ac.uk.; Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK. vw260@cam.ac.uk.; Department of Psychology, University of Cambridge, Cambridge, UK. vw260@cam.ac.uk.
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