Computational microbiome pharmacology analysis elucidates the anti-cancer potential of vaginal microbes and metabolites.

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Title: Computational microbiome pharmacology analysis elucidates the anti-cancer potential of vaginal microbes and metabolites.
Authors: Lawore DC; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States., Jena S; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States., Berard AR; Department of Obstetrics and Gynecology, University of Manitoba, Winnipeg, MB, Canada.; Center for Global Health and Diseases, Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, United States., Birse K; Department of Obstetrics and Gynecology, University of Manitoba, Winnipeg, MB, Canada.; Center for Global Health and Diseases, Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, United States., Lamont A; Department of Obstetrics and Gynecology, University of Manitoba, Winnipeg, MB, Canada., Mackelprang RD; Department of Global Health, University of Washington, Seattle, WA, United States., Noel-Romas L; Department of Obstetrics and Gynecology, University of Manitoba, Winnipeg, MB, Canada.; Center for Global Health and Diseases, Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, United States., Perner M; Department of Medical Microbiology and Infectious Disease, University of Manitoba, Winnipeg, MB, Canada., Hou X; Department of Global Health, University of Washington, Seattle, WA, United States., Irungu E; Partners in Health Research and Development, Kenya Medical Research Institute, Nairobi, Kenya., Mugo N; Department of Global Health, University of Washington, Seattle, WA, United States.; Partners in Health Research and Development, Kenya Medical Research Institute, Nairobi, Kenya., Knodel S; Department of Obstetrics and Gynecology, University of Manitoba, Winnipeg, MB, Canada.; Center for Global Health and Diseases, Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, United States., Muwonge TR; Infectious Diseases Institute, Makerere University, Kampala, Uganda., Katabira E; Infectious Diseases Institute, Makerere University, Kampala, Uganda., Hughes SM; Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, United States., Levy C; Fred Hutchinson Cancer Research Center, Seattle, WA, United States., Calienes FL; Fred Hutchinson Cancer Research Center, Seattle, WA, United States., Hladik F; Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, United States.; Fred Hutchinson Cancer Research Center, Seattle, WA, United States.; Department of Medicine, University of Washington, Seattle, WA, United States., Lingappa JR; Department of Global Health, University of Washington, Seattle, WA, United States.; Department of Medicine, University of Washington, Seattle, WA, United States.; Department of Pediatrics, University of Washington, Seattle, WA, United States., Burgener AD; Department of Obstetrics and Gynecology, University of Manitoba, Winnipeg, MB, Canada.; Center for Global Health and Diseases, Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, United States.; Department of Medicine Solna, Karolinska Institutet, Solna, Sweden., Green LN; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States., Brubaker DK; Center for Global Health and Diseases, Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, United States.; The Blood Heart Lung Immunology Research Center, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, OH, United States.
Source: Frontiers in microbiology [Front Microbiol] 2025 Sep 16; Vol. 16, pp. 1602217. Date of Electronic Publication: 2025 Sep 16 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101548977 Publication Model: eCollection Cited Medium: Print ISSN: 1664-302X (Print) Linking ISSN: 1664302X NLM ISO Abbreviation: Front Microbiol Subsets: PubMed not MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Lawore+DC%22">Lawore DC</searchLink>; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States.<br /><searchLink fieldCode="AU" term="%22Jena+S%22">Jena S</searchLink>; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States.<br /><searchLink fieldCode="AU" term="%22Berard+AR%22">Berard AR</searchLink>; Department of Obstetrics and Gynecology, University of Manitoba, Winnipeg, MB, Canada.; Center for Global Health and Diseases, Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, United States.<br /><searchLink fieldCode="AU" term="%22Birse+K%22">Birse K</searchLink>; Department of Obstetrics and Gynecology, University of Manitoba, Winnipeg, MB, Canada.; Center for Global Health and Diseases, Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, United States.<br /><searchLink fieldCode="AU" term="%22Lamont+A%22">Lamont A</searchLink>; Department of Obstetrics and Gynecology, University of Manitoba, Winnipeg, MB, Canada.<br /><searchLink fieldCode="AU" term="%22Mackelprang+RD%22">Mackelprang RD</searchLink>; Department of Global Health, University of Washington, Seattle, WA, United States.<br /><searchLink fieldCode="AU" term="%22Noel-Romas+L%22">Noel-Romas L</searchLink>; Department of Obstetrics and Gynecology, University of Manitoba, Winnipeg, MB, Canada.; Center for Global Health and Diseases, Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, United States.<br /><searchLink fieldCode="AU" term="%22Perner+M%22">Perner M</searchLink>; Department of Medical Microbiology and Infectious Disease, University of Manitoba, Winnipeg, MB, Canada.<br /><searchLink fieldCode="AU" term="%22Hou+X%22">Hou X</searchLink>; Department of Global Health, University of Washington, Seattle, WA, United States.<br /><searchLink fieldCode="AU" term="%22Irungu+E%22">Irungu E</searchLink>; Partners in Health Research and Development, Kenya Medical Research Institute, Nairobi, Kenya.<br /><searchLink fieldCode="AU" term="%22Mugo+N%22">Mugo N</searchLink>; Department of Global Health, University of Washington, Seattle, WA, United States.; Partners in Health Research and Development, Kenya Medical Research Institute, Nairobi, Kenya.<br /><searchLink fieldCode="AU" term="%22Knodel+S%22">Knodel S</searchLink>; Department of Obstetrics and Gynecology, University of Manitoba, Winnipeg, MB, Canada.; Center for Global Health and Diseases, Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, United States.<br /><searchLink fieldCode="AU" term="%22Muwonge+TR%22">Muwonge TR</searchLink>; Infectious Diseases Institute, Makerere University, Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Katabira+E%22">Katabira E</searchLink>; Infectious Diseases Institute, Makerere University, Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Hughes+SM%22">Hughes SM</searchLink>; Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, United States.<br /><searchLink fieldCode="AU" term="%22Levy+C%22">Levy C</searchLink>; Fred Hutchinson Cancer Research Center, Seattle, WA, United States.<br /><searchLink fieldCode="AU" term="%22Calienes+FL%22">Calienes FL</searchLink>; Fred Hutchinson Cancer Research Center, Seattle, WA, United States.<br /><searchLink fieldCode="AU" term="%22Hladik+F%22">Hladik F</searchLink>; Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, United States.; Fred Hutchinson Cancer Research Center, Seattle, WA, United States.; Department of Medicine, University of Washington, Seattle, WA, United States.<br /><searchLink fieldCode="AU" term="%22Lingappa+JR%22">Lingappa JR</searchLink>; Department of Global Health, University of Washington, Seattle, WA, United States.; Department of Medicine, University of Washington, Seattle, WA, United States.; Department of Pediatrics, University of Washington, Seattle, WA, United States.<br /><searchLink fieldCode="AU" term="%22Burgener+AD%22">Burgener AD</searchLink>; Department of Obstetrics and Gynecology, University of Manitoba, Winnipeg, MB, Canada.; Center for Global Health and Diseases, Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, United States.; Department of Medicine Solna, Karolinska Institutet, Solna, Sweden.<br /><searchLink fieldCode="AU" term="%22Green+LN%22">Green LN</searchLink>; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States.<br /><searchLink fieldCode="AU" term="%22Brubaker+DK%22">Brubaker DK</searchLink>; Center for Global Health and Diseases, Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, United States.; The Blood Heart Lung Immunology Research Center, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, OH, United States.
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