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Neuropharmacological evaluation of hydralazine hydrazone derivatives: Synthesis, In silico, and zebrafish studies.

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Title: Neuropharmacological evaluation of hydralazine hydrazone derivatives: Synthesis, In silico, and zebrafish studies.
Authors: Romão IC; Laboratory of Chemical-Pharmacological and Environmental Bioassays - LabQFAm, Graduate Program in Natural Sciences, State University of Ceará, Fortaleza, Ceará, Brazil., Alves AMB; Laboratory of Chemical-Pharmacological and Environmental Bioassays - LabQFAm, Graduate Program in Natural Sciences, State University of Ceará, Fortaleza, Ceará, Brazil., de Sousa Silva T; Laboratory of Chemical-Pharmacological and Environmental Bioassays - LabQFAm, Graduate Program in Natural Sciences, State University of Ceará, Fortaleza, Ceará, Brazil., Marinho MM; Laboratory of Bioprospecting and Monitoring of Natural Resources - LBMRN, Graduate Program in Natural Sciences, State University of Ceará, Fortaleza, Ceará, Brazil., Marinho ES; Laboratory of Bioprospecting and Monitoring of Natural Resources - LBMRN, Graduate Program in Natural Sciences, State University of Ceará, Fortaleza, Ceará, Brazil., da Rocha MN; Laboratory of Bioprospecting and Monitoring of Natural Resources - LBMRN, Graduate Program in Natural Sciences, State University of Ceará, Fortaleza, Ceará, Brazil., Dias JML; State University of Vale do Acaraú, Chemistry Course, Sobral, CE, Brazil., Fernandes GC; Postgraduate Program in Biotechnology, Sobral, CE, Brazil., Pinto FDCL; Federal University of Sergipe, Graduate Program in Chemistry - PPGQ-UFS, São Cristovão, SE, Brazil., de Castro Gomes AF; Center for Molecular and Environmental Biology, University of Minho, School of Sciences, Department of Biology, Braga, Portugal., de Menezes JESA; Laboratory of Chemical-Pharmacological and Environmental Bioassays - LabQFAm, Graduate Program in Natural Sciences, State University of Ceará, Fortaleza, Ceará, Brazil., Siqueira SMC; Laboratory of Chemical-Pharmacological and Environmental Bioassays - LabQFAm, Graduate Program in Natural Sciences, State University of Ceará, Fortaleza, Ceará, Brazil., Dos Santos HS; Laboratory of Chemical-Pharmacological and Environmental Bioassays - LabQFAm, Graduate Program in Natural Sciences, State University of Ceará, Fortaleza, Ceará, Brazil; State University of Vale do Acaraú, Chemistry Course, Sobral, CE, Brazil; Postgraduate Program in Biotechnology, Sobral, CE, Brazil. Electronic address: helcio_santos@uvanet.br.
Source: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2025 Oct 30; Vol. 786, pp. 152728. Date of Electronic Publication: 2025 Sep 29.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Neuropharmacological evaluation of hydralazine hydrazone derivatives: Synthesis, In silico, and zebrafish studies.
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  Data: <searchLink fieldCode="AU" term="%22Romão+IC%22">Romão IC</searchLink>; Laboratory of Chemical-Pharmacological and Environmental Bioassays - LabQFAm, Graduate Program in Natural Sciences, State University of Ceará, Fortaleza, Ceará, Brazil.<br /><searchLink fieldCode="AU" term="%22Alves+AMB%22">Alves AMB</searchLink>; Laboratory of Chemical-Pharmacological and Environmental Bioassays - LabQFAm, Graduate Program in Natural Sciences, State University of Ceará, Fortaleza, Ceará, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Sousa+Silva+T%22">de Sousa Silva T</searchLink>; Laboratory of Chemical-Pharmacological and Environmental Bioassays - LabQFAm, Graduate Program in Natural Sciences, State University of Ceará, Fortaleza, Ceará, Brazil.<br /><searchLink fieldCode="AU" term="%22Marinho+MM%22">Marinho MM</searchLink>; Laboratory of Bioprospecting and Monitoring of Natural Resources - LBMRN, Graduate Program in Natural Sciences, State University of Ceará, Fortaleza, Ceará, Brazil.<br /><searchLink fieldCode="AU" term="%22Marinho+ES%22">Marinho ES</searchLink>; Laboratory of Bioprospecting and Monitoring of Natural Resources - LBMRN, Graduate Program in Natural Sciences, State University of Ceará, Fortaleza, Ceará, Brazil.<br /><searchLink fieldCode="AU" term="%22da+Rocha+MN%22">da Rocha MN</searchLink>; Laboratory of Bioprospecting and Monitoring of Natural Resources - LBMRN, Graduate Program in Natural Sciences, State University of Ceará, Fortaleza, Ceará, Brazil.<br /><searchLink fieldCode="AU" term="%22Dias+JML%22">Dias JML</searchLink>; State University of Vale do Acaraú, Chemistry Course, Sobral, CE, Brazil.<br /><searchLink fieldCode="AU" term="%22Fernandes+GC%22">Fernandes GC</searchLink>; Postgraduate Program in Biotechnology, Sobral, CE, Brazil.<br /><searchLink fieldCode="AU" term="%22Pinto+FDCL%22">Pinto FDCL</searchLink>; Federal University of Sergipe, Graduate Program in Chemistry - PPGQ-UFS, São Cristovão, SE, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Castro+Gomes+AF%22">de Castro Gomes AF</searchLink>; Center for Molecular and Environmental Biology, University of Minho, School of Sciences, Department of Biology, Braga, Portugal.<br /><searchLink fieldCode="AU" term="%22de+Menezes+JESA%22">de Menezes JESA</searchLink>; Laboratory of Chemical-Pharmacological and Environmental Bioassays - LabQFAm, Graduate Program in Natural Sciences, State University of Ceará, Fortaleza, Ceará, Brazil.<br /><searchLink fieldCode="AU" term="%22Siqueira+SMC%22">Siqueira SMC</searchLink>; Laboratory of Chemical-Pharmacological and Environmental Bioassays - LabQFAm, Graduate Program in Natural Sciences, State University of Ceará, Fortaleza, Ceará, Brazil.<br /><searchLink fieldCode="AU" term="%22Dos+Santos+HS%22">Dos Santos HS</searchLink>; Laboratory of Chemical-Pharmacological and Environmental Bioassays - LabQFAm, Graduate Program in Natural Sciences, State University of Ceará, Fortaleza, Ceará, Brazil; State University of Vale do Acaraú, Chemistry Course, Sobral, CE, Brazil; Postgraduate Program in Biotechnology, Sobral, CE, Brazil. Electronic address: helcio_santos@uvanet.br.
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  Data: <searchLink fieldCode="JN" term="%220372516%22">Biochemical and biophysical research communications</searchLink> [Biochem Biophys Res Commun] 2025 Oct 30; Vol. 786, pp. 152728. <i>Date of Electronic Publication: </i>2025 Sep 29.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0372516 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1090-2104 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220006291X%22">0006291X </searchLink><i>NLM ISO Abbreviation: </i>Biochem Biophys Res Commun <i>Subsets: </i>MEDLINE
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