Neurodegeneration emerges at a cellular tipping point between aggregate accumulation and removal. - Cotton MW; Venkatesan S; Beckwith JS; Böken D; Xu CK; Fertan E; Breiter JC; Berkowicz LE; Salazar LS; Von Schulze A; Andrzejewska EA; Brock EE; et al. (BioRxiv : the preprint server for biology, 2025)