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Pyrazinamide kills Mycobacterium tuberculosis via pH-driven weak-acid permeation and cytosolic acidification.

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Bibliographic Details
Title:	Pyrazinamide kills Mycobacterium tuberculosis via pH-driven weak-acid permeation and cytosolic acidification.
Authors:	Laudouze J; Aix Marseille Univ, CNRS, LISM, IMM FR3479, IM2B, Marseille, France., Rokitskaya TI; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia., Abolet A; Aix Marseille Univ, CNRS, LISM, IMM FR3479, IM2B, Marseille, France., Point V; Aix Marseille Univ, CNRS, LISM, IMM FR3479, IM2B, Marseille, France., Firsov AM; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia., Khailova LS; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia., Cavalier JF; Aix Marseille Univ, CNRS, LISM, IMM FR3479, IM2B, Marseille, France., Canaan S; Aix Marseille Univ, CNRS, LISM, IMM FR3479, IM2B, Marseille, France., Baulard AR; Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR9017 - CIIL - Center for Infection and Immunity of Lille, F-59000 Lille, France., Antonenko YN; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia., Gouzy A; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA., Santucci P; Aix Marseille Univ, CNRS, LISM, IMM FR3479, IM2B, Marseille, France.
Source:	BioRxiv : the preprint server for biology [bioRxiv] 2025 Sep 27. Date of Electronic Publication: 2025 Sep 27.
Publication Type:	Journal Article; Preprint
Journal Info:	Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database:	MEDLINE Ultimate

Description
ISSN:	2692-8205
DOI:	10.1101/2025.09.26.678883