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Pyrazinamide kills Mycobacterium tuberculosis via pH-driven weak-acid permeation and cytosolic acidification.

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Title: Pyrazinamide kills Mycobacterium tuberculosis via pH-driven weak-acid permeation and cytosolic acidification.
Authors: Laudouze J; Aix Marseille Univ, CNRS, LISM, IMM FR3479, IM2B, Marseille, France., Rokitskaya TI; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia., Abolet A; Aix Marseille Univ, CNRS, LISM, IMM FR3479, IM2B, Marseille, France., Point V; Aix Marseille Univ, CNRS, LISM, IMM FR3479, IM2B, Marseille, France., Firsov AM; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia., Khailova LS; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia., Cavalier JF; Aix Marseille Univ, CNRS, LISM, IMM FR3479, IM2B, Marseille, France., Canaan S; Aix Marseille Univ, CNRS, LISM, IMM FR3479, IM2B, Marseille, France., Baulard AR; Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR9017 - CIIL - Center for Infection and Immunity of Lille, F-59000 Lille, France., Antonenko YN; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia., Gouzy A; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA., Santucci P; Aix Marseille Univ, CNRS, LISM, IMM FR3479, IM2B, Marseille, France.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Sep 27. Date of Electronic Publication: 2025 Sep 27.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Pyrazinamide kills Mycobacterium tuberculosis via pH-driven weak-acid permeation and cytosolic acidification.
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  Data: <searchLink fieldCode="AU" term="%22Laudouze+J%22">Laudouze J</searchLink>; Aix Marseille Univ, CNRS, LISM, IMM FR3479, IM2B, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Rokitskaya+TI%22">Rokitskaya TI</searchLink>; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.<br /><searchLink fieldCode="AU" term="%22Abolet+A%22">Abolet A</searchLink>; Aix Marseille Univ, CNRS, LISM, IMM FR3479, IM2B, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Point+V%22">Point V</searchLink>; Aix Marseille Univ, CNRS, LISM, IMM FR3479, IM2B, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Firsov+AM%22">Firsov AM</searchLink>; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.<br /><searchLink fieldCode="AU" term="%22Khailova+LS%22">Khailova LS</searchLink>; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.<br /><searchLink fieldCode="AU" term="%22Cavalier+JF%22">Cavalier JF</searchLink>; Aix Marseille Univ, CNRS, LISM, IMM FR3479, IM2B, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Canaan+S%22">Canaan S</searchLink>; Aix Marseille Univ, CNRS, LISM, IMM FR3479, IM2B, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Baulard+AR%22">Baulard AR</searchLink>; Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR9017 - CIIL - Center for Infection and Immunity of Lille, F-59000 Lille, France.<br /><searchLink fieldCode="AU" term="%22Antonenko+YN%22">Antonenko YN</searchLink>; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.<br /><searchLink fieldCode="AU" term="%22Gouzy+A%22">Gouzy A</searchLink>; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Santucci+P%22">Santucci P</searchLink>; Aix Marseille Univ, CNRS, LISM, IMM FR3479, IM2B, Marseille, France.
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  Data: <searchLink fieldCode="JN" term="%22101680187%22">BioRxiv : the preprint server for biology</searchLink> [bioRxiv] 2025 Sep 27. <i>Date of Electronic Publication: </i>2025 Sep 27.
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              Text: 2025 Sep 27
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