Pyrazinamide kills Mycobacterium tuberculosis via pH-driven weak-acid permeation and cytosolic acidification.
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| Title: | Pyrazinamide kills Mycobacterium tuberculosis via pH-driven weak-acid permeation and cytosolic acidification. |
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| Authors: | Laudouze J; Aix Marseille Univ, CNRS, LISM, IMM FR3479, IM2B, Marseille, France., Rokitskaya TI; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia., Abolet A; Aix Marseille Univ, CNRS, LISM, IMM FR3479, IM2B, Marseille, France., Point V; Aix Marseille Univ, CNRS, LISM, IMM FR3479, IM2B, Marseille, France., Firsov AM; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia., Khailova LS; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia., Cavalier JF; Aix Marseille Univ, CNRS, LISM, IMM FR3479, IM2B, Marseille, France., Canaan S; Aix Marseille Univ, CNRS, LISM, IMM FR3479, IM2B, Marseille, France., Baulard AR; Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR9017 - CIIL - Center for Infection and Immunity of Lille, F-59000 Lille, France., Antonenko YN; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia., Gouzy A; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA., Santucci P; Aix Marseille Univ, CNRS, LISM, IMM FR3479, IM2B, Marseille, France. |
| Source: | BioRxiv : the preprint server for biology [bioRxiv] 2025 Sep 27. Date of Electronic Publication: 2025 Sep 27. |
| Publication Type: | Journal Article; Preprint |
| Journal Info: | Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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