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A multi-ancestry polygenic risk score for Alzheimer disease is associated with cognitive decline, hippocampal atrophy and neuropathological hallmarks in diverse populations.

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Title: A multi-ancestry polygenic risk score for Alzheimer disease is associated with cognitive decline, hippocampal atrophy and neuropathological hallmarks in diverse populations.
Authors: Kurniansyah N; Bioinformatics Program, Boston University, Boston, MA, USA.; Department of Medicine (Biomedical Genetics), Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA., Tasaki S; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., Rehman H; Department of Medicine (Biomedical Genetics), Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA., Zhu C; Department of Medicine (Biomedical Genetics), Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA., Farrell J; Department of Medicine (Biomedical Genetics), Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA., Sherva R; Department of Medicine (Biomedical Genetics), Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.; National Center for PTSD, Behavioral Sciences Division, VA Boston Healthcare System, Boston, USA., Hauger R; Research Service, VA San Diego Healthcare System, San Diego, USA.; Department of Psychiatry, University of California, San Diego, La Jolla, USA.; Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego, USA.; Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, USA., Merritt VC; Research Service, VA San Diego Healthcare System, San Diego, USA.; Department of Psychiatry, University of California, San Diego, La Jolla, USA.; Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego, USA., Panizzon M; Department of Psychiatry, University of California, San Diego, La Jolla, USA.; Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, USA., Zhang R; National Center for PTSD, Behavioral Sciences Division, VA Boston Healthcare System, Boston, USA., Gaziano JM; Million Veteran Program (MVP) Coordinating Center, VA Boston Healthcare System, Boston, MA, USA.; Division of Aging, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA., Gim J; BK21 FOUR, Department of Integrative Biological Sciences, Chosun University, Gwangju, Republic of Korea.; Gwangju Alzheimer's and Related Dementia (GARD) Cohort Research Center, Chosun University, Gwangju, Korea, Republic of (South).; Department of Biomedical Science, Chosun University, Gwangju, Republic of Korea.; Well-ageing Medicare Institute, Chosun University, Gwangju, Republic of Korea., Lee K; BK21 FOUR, Department of Integrative Biological Sciences, Chosun University, Gwangju, Republic of Korea.; Gwangju Alzheimer's and Related Dementia (GARD) Cohort Research Center, Chosun University, Gwangju, Korea, Republic of (South).; Department of Biomedical Science, Chosun University, Gwangju, Republic of Korea.; Korea Brain Research Institute, Daegu, Republic of Korea., Lee DY; Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea., Nho K; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA., Vialle RA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., Mukherjee S; Department of Medicine, School of Medicine, University of Washington, Seattle, WA, USA., Trittschuh EH; Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108.; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98195., Lee AJ; Department of Neurology, Columbia University Medical Center, New York, NY, USA.; Taub Institute for Research on Alzheimer's Disease and The Aging Brain, Columbia University Medical Center, New York, NY, USA.; The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA., Brickman AM; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, and the New York Presbyterian Hospital, New York, NY, USA., Cruchaga C; Department of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA.; NeuroGenomics and Informatics Center, Washington University in St. Louis, St. Louis, MO, USA., Risacher S; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.; Department of Radiology and Imaging Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA., Greve DN; Department of Radiology, Massachusetts General Hospital, Boston, MA, USA., Crane P; Department of Medicine, School of Medicine, University of Washington, Seattle, WA, USA., Martin E; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Bush W; Department of Population and Quantitative Health Sciences, Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA., Mayeux R; Department of Neurology, Columbia University Medical Center, New York, NY, USA.; Taub Institute for Research on Alzheimer's Disease and The Aging Brain, Columbia University Medical Center, New York, NY, USA.; The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA.; The Institute for Genomic Medicine, Columbia University Medical Center, New York, NY, USA., Haines JL; Department of Population and Quantitative Health Sciences, Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA., Pericak-Vance MA; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Logue M; Department of Medicine (Biomedical Genetics), Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.; National Center for PTSD, Behavioral Sciences Division, VA Boston Healthcare System, Boston, USA.; Department of Psychiatry, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., Barnes LL; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., Saykin A; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA., Hohman T; Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN., Wang LS; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA., Schellenberg GC; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA., Ang TFA; Department of Anatomy and Neurobiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA.; Slone Epidemiology Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA., Au R; Department of Medicine (Biomedical Genetics), Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.; Department of Anatomy and Neurobiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA.; Slone Epidemiology Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA.; Framingham Heart Study, Boston University Chobanian & Avedisian School of Medicine, Boston, MA.; Boston University Alzheimer's Disease Research Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA.; Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA.; Department of Epidemiology, Boston University School of Public Health, Boston, MA., Mez J; Framingham Heart Study, Boston University Chobanian & Avedisian School of Medicine, Boston, MA.; Boston University Alzheimer's Disease Research Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA.; Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA., Lunetta KL; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Framingham Heart Study, Boston University Chobanian & Avedisian School of Medicine, Boston, MA., Zhang X; Bioinformatics Program, Boston University, Boston, MA, USA.; Department of Medicine (Biomedical Genetics), Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Farrer LA; Bioinformatics Program, Boston University, Boston, MA, USA.; Department of Medicine (Biomedical Genetics), Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Framingham Heart Study, Boston University Chobanian & Avedisian School of Medicine, Boston, MA.; Boston University Alzheimer's Disease Research Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA.; Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA.; Department of Epidemiology, Boston University School of Public Health, Boston, MA.; Department of Ophthalmology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Corporate Authors: VA Million Veteran Program, Alzheimer’s Disease Genetics Consortium, Alzheimer Disease Sequencing Project
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2025 Sep 27. Date of Electronic Publication: 2025 Sep 27.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: A multi-ancestry polygenic risk score for Alzheimer disease is associated with cognitive decline, hippocampal atrophy and neuropathological hallmarks in diverse populations.
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  Data: <searchLink fieldCode="AU" term="%22Kurniansyah+N%22">Kurniansyah N</searchLink>; Bioinformatics Program, Boston University, Boston, MA, USA.; Department of Medicine (Biomedical Genetics), Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Tasaki+S%22">Tasaki S</searchLink>; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Rehman+H%22">Rehman H</searchLink>; Department of Medicine (Biomedical Genetics), Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Zhu+C%22">Zhu C</searchLink>; Department of Medicine (Biomedical Genetics), Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Farrell+J%22">Farrell J</searchLink>; Department of Medicine (Biomedical Genetics), Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Sherva+R%22">Sherva R</searchLink>; Department of Medicine (Biomedical Genetics), Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.; National Center for PTSD, Behavioral Sciences Division, VA Boston Healthcare System, Boston, USA.<br /><searchLink fieldCode="AU" term="%22Hauger+R%22">Hauger R</searchLink>; Research Service, VA San Diego Healthcare System, San Diego, USA.; Department of Psychiatry, University of California, San Diego, La Jolla, USA.; Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego, USA.; Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, USA.<br /><searchLink fieldCode="AU" term="%22Merritt+VC%22">Merritt VC</searchLink>; Research Service, VA San Diego Healthcare System, San Diego, USA.; Department of Psychiatry, University of California, San Diego, La Jolla, USA.; Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego, USA.<br /><searchLink fieldCode="AU" term="%22Panizzon+M%22">Panizzon M</searchLink>; Department of Psychiatry, University of California, San Diego, La Jolla, USA.; Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+R%22">Zhang R</searchLink>; National Center for PTSD, Behavioral Sciences Division, VA Boston Healthcare System, Boston, USA.<br /><searchLink fieldCode="AU" term="%22Gaziano+JM%22">Gaziano JM</searchLink>; Million Veteran Program (MVP) Coordinating Center, VA Boston Healthcare System, Boston, MA, USA.; Division of Aging, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Gim+J%22">Gim J</searchLink>; BK21 FOUR, Department of Integrative Biological Sciences, Chosun University, Gwangju, Republic of Korea.; Gwangju Alzheimer's and Related Dementia (GARD) Cohort Research Center, Chosun University, Gwangju, Korea, Republic of (South).; Department of Biomedical Science, Chosun University, Gwangju, Republic of Korea.; Well-ageing Medicare Institute, Chosun University, Gwangju, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+K%22">Lee K</searchLink>; BK21 FOUR, Department of Integrative Biological Sciences, Chosun University, Gwangju, Republic of Korea.; Gwangju Alzheimer's and Related Dementia (GARD) Cohort Research Center, Chosun University, Gwangju, Korea, Republic of (South).; Department of Biomedical Science, Chosun University, Gwangju, Republic of Korea.; Korea Brain Research Institute, Daegu, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+DY%22">Lee DY</searchLink>; Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Nho+K%22">Nho K</searchLink>; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Vialle+RA%22">Vialle RA</searchLink>; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Mukherjee+S%22">Mukherjee S</searchLink>; Department of Medicine, School of Medicine, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Trittschuh+EH%22">Trittschuh EH</searchLink>; Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108.; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98195.<br /><searchLink fieldCode="AU" term="%22Lee+AJ%22">Lee AJ</searchLink>; Department of Neurology, Columbia University Medical Center, New York, NY, USA.; Taub Institute for Research on Alzheimer's Disease and The Aging Brain, Columbia University Medical Center, New York, NY, USA.; The Gertrude H. 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      – TitleFull: A multi-ancestry polygenic risk score for Alzheimer disease is associated with cognitive decline, hippocampal atrophy and neuropathological hallmarks in diverse populations.
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            NameFull: Zhang X
      – PersonEntity:
          Name:
            NameFull: Farrer LA
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 27
              M: 09
              Text: 2025 Sep 27
              Type: published
              Y: 2025
          Titles:
            – TitleFull: MedRxiv : the preprint server for health sciences
              Type: main
ResultId 1