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Novel approaches to the stratified management of knee osteoarthritis.

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Title: Novel approaches to the stratified management of knee osteoarthritis.
Authors: Fuggle NR; MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK., Chapurlat R; INSERM UMR 1033, Université Claude Bernard-Lyon 1, Hôpital Edouard-Herriot, Lyon, France., Laslop A; Scientific Office, Federal Office for Safety in Health Care, Vienna, Austria., Al-Daghri N; Biomarkers of Chronic Disease Chair, Biochemistry Department, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia., Alokail M; Protein Research Chair, Biochemistry Department, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia., Thiyagarajan JA; Ageing and Health Unit, World Health Organization, Geneva, Switzerland., Balkowiec-Iskra E; Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland., Berenbaum F; Sorbonne University, INSERM, AP-HP Saint-Antoine Hospital, Paris, France., Bemden AB; Musculoskeletal Research International, Key Biscayne, FL, USA., Borg JJ; Malta Medicines Authority, San Ġwann, Malta., Bruyère O; Research Unit in Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium., Burlet N; Research Unit in Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium., Cavalier E; Department of Clinical Chemistry, University of Liège, CIRM, CHU de Liège, Liège, Belgium., Rosa MM; Laboratory of Clinical and Therapeutical Pharmacology, University of Lisbon, Lisbon, Portugal., Conaghan PG; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK., Cooper C; MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK.; NIHR Southampton Biomedical Research Centre, University of Southampton, Southampton, UK.; NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK., Dennison EM; MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK., Englund M; Clinical Epidemiology Unit, Orthopedics, Faculty of Medicine, Department of Clinical Sciences Lund, Lund University, Lund, Sweden., Im GI; Department of Orthopedics, Dongguk University Ilsan Hospital, Goyang Gyeonggi-Do, Republic of Korea., Haugen IK; Center for Treatment of Rheumatic and Musculoskeletal Diseases, Diakonhjemmet Hospital, Oslo, Norway., Hiligsmann M; Department of Health Services Research, CAPHRI Care and Public Health Research Institute, Maastricht University, Maastricht, the Netherlands., Kurth A; Johann Wolfgang Goethe University, Frankfurt, Germany., Lane N; Department of Medicine, University of California Davis, Sacramento, CA, USA., Lories R; Skeletal Biology and Engineering Research Center, Department of Development and Regeneration, KU Leuven and Division of Rheumatology, UZ Leuven, Leuven, Belgium., Marlovits S; Centre for Cartilage Regeneration, Orthobiologics and Joint Preservation, Vienna, Austria., Matijevic R; University of Novi Sad, Faculty of Medicine, Clinic for Orthopedic Surgery and Traumatology, Clinical Center of Vojvodina, Novi Sad, Serbia., Mobasheri A; Research Unit of Health Sciences and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland.; Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania.; Department of Joint Surgery, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China., Ormarsdóttir S; Medicine Assessment and Licencing, Icelandic Medicines Agency, Reykjavik, Iceland., Yerro MCP; Agencia Española de Medicamentos Y Productos Sanitarios, Madrid, Spain., Radermecker RP; Department of Diabetes, Nutrition and Metabolic Disorders, Clinical Pharmacology, University of Liège, Liège, Belgium., Rannou F; Service de Rééducation et de Réadaptation de l'Appareil Locomoteur et des Pathologies du Rachis, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Université Paris Cité, Paris, France., Sepodes B; Faculdade de Farmácia, Universidade de Lisboa, Lisbon, Portugal.; Laboratory of Systems Integration Pharmacology, Clinical and Regulatory Science, Research Institute for Medicines of the University of Lisbon, Lisbon, Portugal., Silverman S; Cedars-Sinai Medical Center, Los Angeles, CA, USA., Torre C; Faculdade de Farmácia, Universidade de Lisboa, Lisbon, Portugal.; Laboratory of Systems Integration Pharmacology, Clinical and Regulatory Science, Research Institute for Medicines of the University of Lisbon, Lisbon, Portugal., Veronese N; Saint Camillus International University of Health Sciences, Rome, Italy., Rizzoli R; Division of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland., Reginster JY; Protein Research Chair, Biochemistry Department, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia., Harvey NC; MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK. nch@mrc.soton.ac.uk.; NIHR Southampton Biomedical Research Centre, University of Southampton, Southampton, UK. nch@mrc.soton.ac.uk.
Source: Nature reviews. Rheumatology [Nat Rev Rheumatol] 2025 Nov; Vol. 21 (11), pp. 684-695. Date of Electronic Publication: 2025 Oct 03.
Publication Type: Journal Article; Review
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101500080 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1759-4804 (Electronic) Linking ISSN: 17594790 NLM ISO Abbreviation: Nat Rev Rheumatol Subsets: MEDLINE
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Department of Orthopedics, Dongguk University Ilsan Hospital, Goyang Gyeonggi-Do, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Haugen+IK%22">Haugen IK</searchLink>; Center for Treatment of Rheumatic and Musculoskeletal Diseases, Diakonhjemmet Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Hiligsmann+M%22">Hiligsmann M</searchLink>; Department of Health Services Research, CAPHRI Care and Public Health Research Institute, Maastricht University, Maastricht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Kurth+A%22">Kurth A</searchLink>; Johann Wolfgang Goethe University, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Lane+N%22">Lane N</searchLink>; Department of Medicine, University of California Davis, Sacramento, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lories+R%22">Lories R</searchLink>; Skeletal Biology and Engineering Research Center, Department of Development and Regeneration, KU Leuven and Division of Rheumatology, UZ Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Marlovits+S%22">Marlovits S</searchLink>; Centre for Cartilage Regeneration, Orthobiologics and Joint Preservation, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Matijevic+R%22">Matijevic R</searchLink>; University of Novi Sad, Faculty of Medicine, Clinic for Orthopedic Surgery and Traumatology, Clinical Center of Vojvodina, Novi Sad, Serbia.<br /><searchLink fieldCode="AU" term="%22Mobasheri+A%22">Mobasheri A</searchLink>; Research Unit of Health Sciences and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland.; Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania.; Department of Joint Surgery, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Ormarsdóttir+S%22">Ormarsdóttir S</searchLink>; Medicine Assessment and Licencing, Icelandic Medicines Agency, Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Yerro+MCP%22">Yerro MCP</searchLink>; Agencia Española de Medicamentos Y Productos Sanitarios, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Radermecker+RP%22">Radermecker RP</searchLink>; 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Saint Camillus International University of Health Sciences, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Rizzoli+R%22">Rizzoli R</searchLink>; Division of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Reginster+JY%22">Reginster JY</searchLink>; Protein Research Chair, Biochemistry Department, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Harvey+NC%22">Harvey NC</searchLink>; MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK. nch@mrc.soton.ac.uk.; NIHR Southampton Biomedical Research Centre, University of Southampton, Southampton, UK. nch@mrc.soton.ac.uk.
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