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Synthetic genomics-based generation of the tick-borne encephalitis virus Siberian subtype prototype strain and E51K-attenuated variant for vaccine development and antiviral screening.

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Title: Synthetic genomics-based generation of the tick-borne encephalitis virus Siberian subtype prototype strain and E51K-attenuated variant for vaccine development and antiviral screening.
Authors: Kulatay T; National Center for Biotechnology, Astana, 010000, Kazakhstan., Sedova E; National Center for Biotechnology, Astana, 010000, Kazakhstan., Shevtsov A; National Center for Biotechnology, Astana, 010000, Kazakhstan., Zauatbayeva G; National Center for Biotechnology, Astana, 010000, Kazakhstan., Ingirbay B; National Center for Biotechnology, Astana, 010000, Kazakhstan., Keyer V; National Center for Biotechnology, Astana, 010000, Kazakhstan., Shakhmanova Z; National Center for Biotechnology, Astana, 010000, Kazakhstan., Zhumabekova M; National Center for Biotechnology, Astana, 010000, Kazakhstan., Abduraimov Y; National Holding QazBioPharm, Astana, 010000, Kazakhstan., Rsaliyev A; National Holding QazBioPharm, Astana, 010000, Kazakhstan., Sikhayeva N; National Holding QazBioPharm, Astana, 010000, Kazakhstan., Kozlova I; Federal State Budgetary Scientific Institution 'Scientific Сentre for Family Health and Human Reproduction Problems', Irkutsk, 664003, Russian Federation., Zaripov M; Institute of Theoretical and Experimental Biophysics, Pushchino, 142290, Russian Federation., Shustov AV; National Center for Biotechnology, Astana, 010000, Kazakhstan. Electronic address: shustov@biocenter.kz.
Source: Virologica Sinica [Virol Sin] 2025 Oct; Vol. 40 (5), pp. 812-821. Date of Electronic Publication: 2025 Oct 02.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier B.V. on behalf of KeAi Communications Co. Ltd Country of Publication: Netherlands NLM ID: 101514185 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1995-820X (Electronic) Linking ISSN: 1995820X NLM ISO Abbreviation: Virol Sin Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1995-820X
DOI:10.1016/j.virs.2025.09.010