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P-Rex1 limits glucose clearance and suppresses hepatocyte glucose uptake and mitochondrial metabolism independently of its Rac-GEF activity.

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Title: P-Rex1 limits glucose clearance and suppresses hepatocyte glucose uptake and mitochondrial metabolism independently of its Rac-GEF activity.
Authors: Chu JY; Signalling Programme, The Babraham Institute, Cambridge, UK., Tsonou E; Signalling Programme, The Babraham Institute, Cambridge, UK; Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Machin PA; Signalling Programme, The Babraham Institute, Cambridge, UK., MacLellan-Gibson K; Imaging Facility, The Babraham Institute, Cambridge, UK., Roberts AG; Signalling Programme, The Babraham Institute, Cambridge, UK., Chetwynd SA; Signalling Programme, The Babraham Institute, Cambridge, UK., McCormack AT; Department of Chemistry, Maynooth University, Maynooth, Ireland., Stephens JC; Department of Chemistry, Maynooth University, Maynooth, Ireland; The Kathleen Lonsdale Institute for Human Health Research, Maynooth University, Maynooth, Ireland., Benetti E; Department of Drug Science and Technology, University of Turin, Turin, Italy., Kinsella GK; School of Food Sciences and Environmental Health, Technological University Dublin, Dublin, Ireland., Baker D; Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Hornigold DC; Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Welch HCE; Signalling Programme, The Babraham Institute, Cambridge, UK. Electronic address: heidi.welch@babraham.ac.uk.
Source: Cell reports [Cell Rep] 2025 Oct 28; Vol. 44 (10), pp. 116357. Date of Electronic Publication: 2025 Oct 04.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: P-Rex1 limits glucose clearance and suppresses hepatocyte glucose uptake and mitochondrial metabolism independently of its Rac-GEF activity.
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  Data: <searchLink fieldCode="AU" term="%22Chu+JY%22">Chu JY</searchLink>; Signalling Programme, The Babraham Institute, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Tsonou+E%22">Tsonou E</searchLink>; Signalling Programme, The Babraham Institute, Cambridge, UK; Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Machin+PA%22">Machin PA</searchLink>; Signalling Programme, The Babraham Institute, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22MacLellan-Gibson+K%22">MacLellan-Gibson K</searchLink>; Imaging Facility, The Babraham Institute, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Roberts+AG%22">Roberts AG</searchLink>; Signalling Programme, The Babraham Institute, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Chetwynd+SA%22">Chetwynd SA</searchLink>; Signalling Programme, The Babraham Institute, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22McCormack+AT%22">McCormack AT</searchLink>; Department of Chemistry, Maynooth University, Maynooth, Ireland.<br /><searchLink fieldCode="AU" term="%22Stephens+JC%22">Stephens JC</searchLink>; Department of Chemistry, Maynooth University, Maynooth, Ireland; The Kathleen Lonsdale Institute for Human Health Research, Maynooth University, Maynooth, Ireland.<br /><searchLink fieldCode="AU" term="%22Benetti+E%22">Benetti E</searchLink>; Department of Drug Science and Technology, University of Turin, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Kinsella+GK%22">Kinsella GK</searchLink>; School of Food Sciences and Environmental Health, Technological University Dublin, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Baker+D%22">Baker D</searchLink>; Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Hornigold+DC%22">Hornigold DC</searchLink>; Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Welch+HCE%22">Welch HCE</searchLink>; Signalling Programme, The Babraham Institute, Cambridge, UK. Electronic address: heidi.welch@babraham.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%22101573691%22">Cell reports</searchLink> [Cell Rep] 2025 Oct 28; Vol. 44 (10), pp. 116357. <i>Date of Electronic Publication: </i>2025 Oct 04.
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