P-Rex1 limits glucose clearance and suppresses hepatocyte glucose uptake and mitochondrial metabolism independently of its Rac-GEF activity.
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| Title: | P-Rex1 limits glucose clearance and suppresses hepatocyte glucose uptake and mitochondrial metabolism independently of its Rac-GEF activity. |
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| Authors: | Chu JY; Signalling Programme, The Babraham Institute, Cambridge, UK., Tsonou E; Signalling Programme, The Babraham Institute, Cambridge, UK; Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Machin PA; Signalling Programme, The Babraham Institute, Cambridge, UK., MacLellan-Gibson K; Imaging Facility, The Babraham Institute, Cambridge, UK., Roberts AG; Signalling Programme, The Babraham Institute, Cambridge, UK., Chetwynd SA; Signalling Programme, The Babraham Institute, Cambridge, UK., McCormack AT; Department of Chemistry, Maynooth University, Maynooth, Ireland., Stephens JC; Department of Chemistry, Maynooth University, Maynooth, Ireland; The Kathleen Lonsdale Institute for Human Health Research, Maynooth University, Maynooth, Ireland., Benetti E; Department of Drug Science and Technology, University of Turin, Turin, Italy., Kinsella GK; School of Food Sciences and Environmental Health, Technological University Dublin, Dublin, Ireland., Baker D; Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Hornigold DC; Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Welch HCE; Signalling Programme, The Babraham Institute, Cambridge, UK. Electronic address: heidi.welch@babraham.ac.uk. |
| Source: | Cell reports [Cell Rep] 2025 Oct 28; Vol. 44 (10), pp. 116357. Date of Electronic Publication: 2025 Oct 04. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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